Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors
Background Cardiovascular disease competes with breast cancer (BC) as the leading cause of death for females diagnosed with breast cancer. Not much is known concerning morbidity and medicine use in the short and long term after a BC diagnosis. Aim The aim of this study was to determine acute and lon...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2023-07, Vol.149 (7), p.2823-2831 |
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| creator | Fredslund, Stine Overvad Berglund, Agnethe Jensen, Anders Bonde Laursen, Britt Elmedal Juul, Svend Stochholm, Kirstine Gravholt, Claus Højbjerg |
| description | Background
Cardiovascular disease competes with breast cancer (BC) as the leading cause of death for females diagnosed with breast cancer. Not much is known concerning morbidity and medicine use in the short and long term after a BC diagnosis.
Aim
The aim of this study was to determine acute and long-term morbidity in Danish women treated for BC.
Method
A nationwide registry-based cohort study of 100,834 BC patients identified in the clinical database of Danish Breast Cancer Cooperative Group (DBCG) and 1,100,320 (10 per patient) age-matched Danish women without BC, serving as controls.
Morbidity was studied using complete data on hospital contacts and medicinal use.
Results
The risk of hospital contacts was significantly increased in BC survivors compared with controls evaluated both by means of Cox regression and negative binomial regression analysis both during and after cessation of breast cancer treatment. Young age at breast cancer diagnosis was associated with the most pronounced increase in risk of hospital contacts, both during and after cessation of BC treatment.
Medicinal use was significantly increased among BC patients compared to controls, both during (HR 1.27 (1.26–1.28),
p
|
| doi_str_mv | 10.1007/s00432-022-04094-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2685035615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2685035615</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-ed4c5f98874ee725fbabd788f0c914e3ccc434c274757eb267c1b6dec9cb90db3</originalsourceid><addsrcrecordid>eNqFkU1vFSEUhonR2Gv1D7gwJG5cOMrnwCxN60eTJm50TYA509LMwBSYm9x_L9dbNXGhC0J4ec57OLwIvaTkHSVEvS-ECM46wtoSZBDd4RHa0aNEOZeP0Y5QRTvJaH-GnpVyR9pZKvYUnXGpNJVM7tD9VfQZbIERLym7MIZ6wLC382Zr01LEt6msodoZ-xSr9bVgG0e8Zig-h7WGFJuypHiD26Peai7wpY2h3GJ39K3Y2-gh47LlfdinXJ6jJ5OdC7x42M_R908fv1186a6_fr66-HDdeS6H2sEovJwGrZUAUExOzrpRaT0RP1AB3HsvuPBMiTYTONYrT10_gh-8G8jo-Dl6c_Jdc7rfoFSzhOJhnm2EtBXD258JJUiv_ouyXkvCZU9lQ1__hd6lLcc2iGGaU6010UdDdqJ8TqVkmMyaw2LzwVBijtmZU3amZWd-ZmcOrejVg_XmFhh_l_wKqwH8BJR2FW8g_-n9D9sfhlOlmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2831888087</pqid></control><display><type>article</type><title>Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors</title><source>Springer Nature - Complete Springer Journals</source><creator>Fredslund, Stine Overvad ; Berglund, Agnethe ; Jensen, Anders Bonde ; Laursen, Britt Elmedal ; Juul, Svend ; Stochholm, Kirstine ; Gravholt, Claus Højbjerg</creator><creatorcontrib>Fredslund, Stine Overvad ; Berglund, Agnethe ; Jensen, Anders Bonde ; Laursen, Britt Elmedal ; Juul, Svend ; Stochholm, Kirstine ; Gravholt, Claus Højbjerg</creatorcontrib><description>Background
Cardiovascular disease competes with breast cancer (BC) as the leading cause of death for females diagnosed with breast cancer. Not much is known concerning morbidity and medicine use in the short and long term after a BC diagnosis.
Aim
The aim of this study was to determine acute and long-term morbidity in Danish women treated for BC.
Method
A nationwide registry-based cohort study of 100,834 BC patients identified in the clinical database of Danish Breast Cancer Cooperative Group (DBCG) and 1,100,320 (10 per patient) age-matched Danish women without BC, serving as controls.
Morbidity was studied using complete data on hospital contacts and medicinal use.
Results
The risk of hospital contacts was significantly increased in BC survivors compared with controls evaluated both by means of Cox regression and negative binomial regression analysis both during and after cessation of breast cancer treatment. Young age at breast cancer diagnosis was associated with the most pronounced increase in risk of hospital contacts, both during and after cessation of BC treatment.
Medicinal use was significantly increased among BC patients compared to controls, both during (HR 1.27 (1.26–1.28),
p
< 0.0001) and after BC treatment (HR 1.18 (1.17–1.19),
p
< 0.0001, and present for all subgroups of medicine.
Conclusion
Overall, BC survivors have a pronounced increase in hospital contacts and medicinal use compared to women without BC. Premenopausal status at BC diagnosis was associated with an overall higher excess morbidity and a higher burden both during and after treatment.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-022-04094-y</identifier><identifier>PMID: 35781525</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Breast cancer ; breast neoplasms ; Cancer Research ; cancer therapy ; Cardiovascular diseases ; cohort studies ; death ; Diagnosis ; Hematology ; hospitals ; Internal Medicine ; Medicine ; Medicine & Public Health ; Morbidity ; Oncology ; Patients ; premenopause ; regression analysis ; risk</subject><ispartof>Journal of cancer research and clinical oncology, 2023-07, Vol.149 (7), p.2823-2831</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-ed4c5f98874ee725fbabd788f0c914e3ccc434c274757eb267c1b6dec9cb90db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-022-04094-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-022-04094-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35781525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fredslund, Stine Overvad</creatorcontrib><creatorcontrib>Berglund, Agnethe</creatorcontrib><creatorcontrib>Jensen, Anders Bonde</creatorcontrib><creatorcontrib>Laursen, Britt Elmedal</creatorcontrib><creatorcontrib>Juul, Svend</creatorcontrib><creatorcontrib>Stochholm, Kirstine</creatorcontrib><creatorcontrib>Gravholt, Claus Højbjerg</creatorcontrib><title>Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Background
Cardiovascular disease competes with breast cancer (BC) as the leading cause of death for females diagnosed with breast cancer. Not much is known concerning morbidity and medicine use in the short and long term after a BC diagnosis.
Aim
The aim of this study was to determine acute and long-term morbidity in Danish women treated for BC.
Method
A nationwide registry-based cohort study of 100,834 BC patients identified in the clinical database of Danish Breast Cancer Cooperative Group (DBCG) and 1,100,320 (10 per patient) age-matched Danish women without BC, serving as controls.
Morbidity was studied using complete data on hospital contacts and medicinal use.
Results
The risk of hospital contacts was significantly increased in BC survivors compared with controls evaluated both by means of Cox regression and negative binomial regression analysis both during and after cessation of breast cancer treatment. Young age at breast cancer diagnosis was associated with the most pronounced increase in risk of hospital contacts, both during and after cessation of BC treatment.
Medicinal use was significantly increased among BC patients compared to controls, both during (HR 1.27 (1.26–1.28),
p
< 0.0001) and after BC treatment (HR 1.18 (1.17–1.19),
p
< 0.0001, and present for all subgroups of medicine.
Conclusion
Overall, BC survivors have a pronounced increase in hospital contacts and medicinal use compared to women without BC. Premenopausal status at BC diagnosis was associated with an overall higher excess morbidity and a higher burden both during and after treatment.</description><subject>Breast cancer</subject><subject>breast neoplasms</subject><subject>Cancer Research</subject><subject>cancer therapy</subject><subject>Cardiovascular diseases</subject><subject>cohort studies</subject><subject>death</subject><subject>Diagnosis</subject><subject>Hematology</subject><subject>hospitals</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Oncology</subject><subject>Patients</subject><subject>premenopause</subject><subject>regression analysis</subject><subject>risk</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1vFSEUhonR2Gv1D7gwJG5cOMrnwCxN60eTJm50TYA509LMwBSYm9x_L9dbNXGhC0J4ec57OLwIvaTkHSVEvS-ECM46wtoSZBDd4RHa0aNEOZeP0Y5QRTvJaH-GnpVyR9pZKvYUnXGpNJVM7tD9VfQZbIERLym7MIZ6wLC382Zr01LEt6msodoZ-xSr9bVgG0e8Zig-h7WGFJuypHiD26Peai7wpY2h3GJ39K3Y2-gh47LlfdinXJ6jJ5OdC7x42M_R908fv1186a6_fr66-HDdeS6H2sEovJwGrZUAUExOzrpRaT0RP1AB3HsvuPBMiTYTONYrT10_gh-8G8jo-Dl6c_Jdc7rfoFSzhOJhnm2EtBXD258JJUiv_ouyXkvCZU9lQ1__hd6lLcc2iGGaU6010UdDdqJ8TqVkmMyaw2LzwVBijtmZU3amZWd-ZmcOrejVg_XmFhh_l_wKqwH8BJR2FW8g_-n9D9sfhlOlmQ</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Fredslund, Stine Overvad</creator><creator>Berglund, Agnethe</creator><creator>Jensen, Anders Bonde</creator><creator>Laursen, Britt Elmedal</creator><creator>Juul, Svend</creator><creator>Stochholm, Kirstine</creator><creator>Gravholt, Claus Højbjerg</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20230701</creationdate><title>Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors</title><author>Fredslund, Stine Overvad ; Berglund, Agnethe ; Jensen, Anders Bonde ; Laursen, Britt Elmedal ; Juul, Svend ; Stochholm, Kirstine ; Gravholt, Claus Højbjerg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-ed4c5f98874ee725fbabd788f0c914e3ccc434c274757eb267c1b6dec9cb90db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Breast cancer</topic><topic>breast neoplasms</topic><topic>Cancer Research</topic><topic>cancer therapy</topic><topic>Cardiovascular diseases</topic><topic>cohort studies</topic><topic>death</topic><topic>Diagnosis</topic><topic>Hematology</topic><topic>hospitals</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Oncology</topic><topic>Patients</topic><topic>premenopause</topic><topic>regression analysis</topic><topic>risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fredslund, Stine Overvad</creatorcontrib><creatorcontrib>Berglund, Agnethe</creatorcontrib><creatorcontrib>Jensen, Anders Bonde</creatorcontrib><creatorcontrib>Laursen, Britt Elmedal</creatorcontrib><creatorcontrib>Juul, Svend</creatorcontrib><creatorcontrib>Stochholm, Kirstine</creatorcontrib><creatorcontrib>Gravholt, Claus Højbjerg</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fredslund, Stine Overvad</au><au>Berglund, Agnethe</au><au>Jensen, Anders Bonde</au><au>Laursen, Britt Elmedal</au><au>Juul, Svend</au><au>Stochholm, Kirstine</au><au>Gravholt, Claus Højbjerg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>149</volume><issue>7</issue><spage>2823</spage><epage>2831</epage><pages>2823-2831</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Background
Cardiovascular disease competes with breast cancer (BC) as the leading cause of death for females diagnosed with breast cancer. Not much is known concerning morbidity and medicine use in the short and long term after a BC diagnosis.
Aim
The aim of this study was to determine acute and long-term morbidity in Danish women treated for BC.
Method
A nationwide registry-based cohort study of 100,834 BC patients identified in the clinical database of Danish Breast Cancer Cooperative Group (DBCG) and 1,100,320 (10 per patient) age-matched Danish women without BC, serving as controls.
Morbidity was studied using complete data on hospital contacts and medicinal use.
Results
The risk of hospital contacts was significantly increased in BC survivors compared with controls evaluated both by means of Cox regression and negative binomial regression analysis both during and after cessation of breast cancer treatment. Young age at breast cancer diagnosis was associated with the most pronounced increase in risk of hospital contacts, both during and after cessation of BC treatment.
Medicinal use was significantly increased among BC patients compared to controls, both during (HR 1.27 (1.26–1.28),
p
< 0.0001) and after BC treatment (HR 1.18 (1.17–1.19),
p
< 0.0001, and present for all subgroups of medicine.
Conclusion
Overall, BC survivors have a pronounced increase in hospital contacts and medicinal use compared to women without BC. Premenopausal status at BC diagnosis was associated with an overall higher excess morbidity and a higher burden both during and after treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35781525</pmid><doi>10.1007/s00432-022-04094-y</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2023-07, Vol.149 (7), p.2823-2831 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Breast cancer breast neoplasms Cancer Research cancer therapy Cardiovascular diseases cohort studies death Diagnosis Hematology hospitals Internal Medicine Medicine Medicine & Public Health Morbidity Oncology Patients premenopause regression analysis risk |
| title | Increased morbidity evaluated on hospital contacts and prescriptions among 100,834 Danish breast cancer survivors |
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