Synthesis of the new nucleoside 5′-alpha-iminophosphates using Staudinger reaction

[Display omitted] •New compounds - nucleoside 5′-α-iminophosphates were obtained using Staudinger reaction.•It is alpha-phosphate mimetic nucleotide in which an oxygen atom is replaced by a imino (=N-R)-group.•Nucleoside 5′-alpha-iminophosphates unlike relevant amidates are resonance-stabilized, ins...

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Veröffentlicht in:	Bioorganic chemistry 2022-10, Vol.127, p.105987-105987, Article 105987
Hauptverfasser:	Vasilyeva, Svetlana V., Kuznetsova, Alexandra A., Baranovskaya, Elizaveta E., Kuznetsov, Nikita A., Lomzov, Alexander A., Pyshnyi, Dmitrii V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-phosphate mimetic nucleotides Nucleoside 5′-α-iminophosphates Staudinger reaction Terminal deoxynucleotidyl transferase substrate
Online-Zugang:	Volltext
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