Statistical learning in preclinical drug proarrhythmic assessment

Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in understanding the drug-induced TdP in preclinical studies. However, a comprehensive statistical learning framework that can a...

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Veröffentlicht in:	Journal of biopharmaceutical statistics 2022-05, Vol.32 (3), p.450-473
Hauptverfasser:	Xi, Nan Miles, Hsu, Yu-Yi, Dang, Qianyu, Huang, Dalong Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	drug safety assessment ordinal logistic regression ordinal random forest prediction of torsades de pointes statistical learning
Online-Zugang:	Volltext
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