Elimination of light chain tailing in reducing capillary electrophoresis with sodium dodecyl sulfate analysis of a monoclonal antibody

Capillary electrophoresis with sodium dodecyl sulfate (CE‐SDS) is a common analytical technique for investigating the purity and molecular size heterogeneity of monoclonal antibody (mAb) drugs. In reducing CE‐SDS analysis of mAb‐A, the light chain (LC) peak exhibited severe tailing, seriously affect...

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Veröffentlicht in:	Electrophoresis 2022-10, Vol.43 (18-19), p.1850-1858
Hauptverfasser:	Wang, Si‐Tao, Gao, Han, Shen, Bin‐Bin, Wang, Haibin, Fang, Wei‐Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - analysis Capillary electrophoresis Chains Detergents Electrophoresis Electrophoresis, Capillary - methods Heterogeneity light chain Monoclonal antibodies monoclonal antibody Purity Sodium Sodium dodecyl sulfate Sodium Dodecyl Sulfate - chemistry sodium hexadecyl sulfate Sodium Tetradecyl Sulfate Sulfates tailing Tailings
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