Safety and immunogenicity of a serum-free purified Vero rabies vaccine in healthy adults: A randomised phase II pre-exposure prophylaxis study

•A three-dose PrEP regimen with PVRV-NG was immunogenically non-inferior to HDCV.•98.3% of PVRV-NG recipients had titres ≥ 0.5 IU/mL.•Primary PrEP with PVRV-NG effectively primed for a robust immune response to booster.•PVRV-NG had an acceptable safety profile and was well tolerated in healthy adult...

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