Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis
Objectives Vorticity calculated using computational fluid dynamics (CFD) could assess the flow disturbance generated by coronary stenosis. The purpose of this study was to investigate whether vorticity would be an underlying cause of functionally significant stenosis assessed by invasive fractional...
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| Veröffentlicht in: | European radiology 2022-10, Vol.32 (10), p.6859-6867 |
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| creator | Tomizawa, Nobuo Nozaki, Yui Fujimoto, Shinichiro Takahashi, Daigo Kudo, Ayako Kamo, Yuki Aoshima, Chihiro Kawaguchi, Yuko Takamura, Kazuhisa Hiki, Makoto Dohi, Tomotaka Okazaki, Shinya Kumamaru, Kanako K. Minamino, Tohru Aoki, Shigeki |
| description | Objectives
Vorticity calculated using computational fluid dynamics (CFD) could assess the flow disturbance generated by coronary stenosis. The purpose of this study was to investigate whether vorticity would be an underlying cause of functionally significant stenosis assessed by invasive fractional flow reserve (FFR).
Methods
This retrospective study included 113 patients who underwent coronary CT angiography showing intermediate stenosis and subsequent invasive FFR between December 2015 and March 2020. Vorticity at the stenosis site was calculated using a mesh-free CFD method. We also evaluated the minimum lumen area (MLA) and diameter stenosis (DS) of the lesion. Invasive FFR of ≤ 0.80 was considered functionally significant. Data were compared using Student’s
t
-test and logistic regression analysis was performed.
Results
Of the evaluated 144 vessels, 53 vessels (37%) showed FFR ≤ 0.80. Vorticity of significant stenosis was significantly higher than non-significant stenosis (569 ± 78 vs. 328 ± 34 s
−1
,
p
< 0.001). A significant negative relationship was present between vorticity and invasive FFR (
R
2
= 0.31,
p
< 0.001). Multivariate logistic regression analysis including MLA and DS showed that vorticity (per 100 s
−1
, odds ratio: 1.36, 95% confidence interval: 1.21–1.57,
p
< 0.001) was a statistically significant factor to detect functional significance. The area under the receiver operating characteristic curve statistically significantly increased when vorticity was combined with DS and MLA (0.76 vs. 0.87,
p
= 0.001).
Conclusions
Vorticity had a statistically significant negative relationship with invasive FFR independent of geometric stenosis.
Key Points
• Flow disturbance caused by coronary stenosis could be evaluated by calculating vorticity which is defined as the norm of the rotation of the velocity vector.
• Vorticity was statistically significantly higher in stenosis with functional significance than stenosis without.
• Vorticity has an additive value to detect functionally significant stenosis over geometrical stenosis. |
| doi_str_mv | 10.1007/s00330-022-08974-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2684096954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2714190201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-1485abc3904178da073338c3871b061f34e9f5d1e1fcd748be3cb7df87825cad3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhosouK7-AU8BL16qk49u0qMsfsGCFz2HNE2WLN1mzbRK_73RFRQPwkCG8LwvzFMU5xSuKIC8RgDOoQTGSlC1FCU7KGZUcFZSUOLw135cnCBuAKCmQs4KvYwp9iZNxHfxnbQBhzE1preOGESXpyXNRN5iGoINw5R_iSHWjOhI9MSPvR1CLui6iWBY98EHa_qB4OD6iAFPiyNvOnRn3--8eLm7fV4-lKun-8flzaq0gqqhpEJVprG8BkGlag1IzrmyXEnawIJ6Llztq5Y66m0rhWoct41svZKKVda0fF5c7nt3Kb6ODge9DWhd15nexRE1WygB9aKuREYv_qCbOKZ8QqYkFbQGBjRTbE_ZFBGT83qXwjaL0hT0p3O9d66zc_3lXLMc4vsQZrhfu_RT_U_qA81thRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2714190201</pqid></control><display><type>article</type><title>Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis</title><source>Springer Nature - Complete Springer Journals</source><creator>Tomizawa, Nobuo ; Nozaki, Yui ; Fujimoto, Shinichiro ; Takahashi, Daigo ; Kudo, Ayako ; Kamo, Yuki ; Aoshima, Chihiro ; Kawaguchi, Yuko ; Takamura, Kazuhisa ; Hiki, Makoto ; Dohi, Tomotaka ; Okazaki, Shinya ; Kumamaru, Kanako K. ; Minamino, Tohru ; Aoki, Shigeki</creator><creatorcontrib>Tomizawa, Nobuo ; Nozaki, Yui ; Fujimoto, Shinichiro ; Takahashi, Daigo ; Kudo, Ayako ; Kamo, Yuki ; Aoshima, Chihiro ; Kawaguchi, Yuko ; Takamura, Kazuhisa ; Hiki, Makoto ; Dohi, Tomotaka ; Okazaki, Shinya ; Kumamaru, Kanako K. ; Minamino, Tohru ; Aoki, Shigeki</creatorcontrib><description>Objectives
Vorticity calculated using computational fluid dynamics (CFD) could assess the flow disturbance generated by coronary stenosis. The purpose of this study was to investigate whether vorticity would be an underlying cause of functionally significant stenosis assessed by invasive fractional flow reserve (FFR).
Methods
This retrospective study included 113 patients who underwent coronary CT angiography showing intermediate stenosis and subsequent invasive FFR between December 2015 and March 2020. Vorticity at the stenosis site was calculated using a mesh-free CFD method. We also evaluated the minimum lumen area (MLA) and diameter stenosis (DS) of the lesion. Invasive FFR of ≤ 0.80 was considered functionally significant. Data were compared using Student’s
t
-test and logistic regression analysis was performed.
Results
Of the evaluated 144 vessels, 53 vessels (37%) showed FFR ≤ 0.80. Vorticity of significant stenosis was significantly higher than non-significant stenosis (569 ± 78 vs. 328 ± 34 s
−1
,
p
< 0.001). A significant negative relationship was present between vorticity and invasive FFR (
R
2
= 0.31,
p
< 0.001). Multivariate logistic regression analysis including MLA and DS showed that vorticity (per 100 s
−1
, odds ratio: 1.36, 95% confidence interval: 1.21–1.57,
p
< 0.001) was a statistically significant factor to detect functional significance. The area under the receiver operating characteristic curve statistically significantly increased when vorticity was combined with DS and MLA (0.76 vs. 0.87,
p
= 0.001).
Conclusions
Vorticity had a statistically significant negative relationship with invasive FFR independent of geometric stenosis.
Key Points
• Flow disturbance caused by coronary stenosis could be evaluated by calculating vorticity which is defined as the norm of the rotation of the velocity vector.
• Vorticity was statistically significantly higher in stenosis with functional significance than stenosis without.
• Vorticity has an additive value to detect functionally significant stenosis over geometrical stenosis.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-08974-2</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiography ; Cardiac ; Computational fluid dynamics ; Computer applications ; Confidence intervals ; Diagnostic Radiology ; Evaluation ; Fluid dynamics ; Hydrodynamics ; Imaging ; Internal Medicine ; Interventional Radiology ; Mathematical analysis ; Medicine ; Medicine & Public Health ; Meshless methods ; Neuroradiology ; Radiology ; Regression analysis ; Statistical analysis ; Statistical significance ; Stenosis ; Ultrasound ; Vorticity</subject><ispartof>European radiology, 2022-10, Vol.32 (10), p.6859-6867</ispartof><rights>The Author(s), under exclusive licence to European Society of Radiology 2022</rights><rights>The Author(s), under exclusive licence to European Society of Radiology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-1485abc3904178da073338c3871b061f34e9f5d1e1fcd748be3cb7df87825cad3</citedby><cites>FETCH-LOGICAL-c418t-1485abc3904178da073338c3871b061f34e9f5d1e1fcd748be3cb7df87825cad3</cites><orcidid>0000-0001-6305-1081</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-08974-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-08974-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Tomizawa, Nobuo</creatorcontrib><creatorcontrib>Nozaki, Yui</creatorcontrib><creatorcontrib>Fujimoto, Shinichiro</creatorcontrib><creatorcontrib>Takahashi, Daigo</creatorcontrib><creatorcontrib>Kudo, Ayako</creatorcontrib><creatorcontrib>Kamo, Yuki</creatorcontrib><creatorcontrib>Aoshima, Chihiro</creatorcontrib><creatorcontrib>Kawaguchi, Yuko</creatorcontrib><creatorcontrib>Takamura, Kazuhisa</creatorcontrib><creatorcontrib>Hiki, Makoto</creatorcontrib><creatorcontrib>Dohi, Tomotaka</creatorcontrib><creatorcontrib>Okazaki, Shinya</creatorcontrib><creatorcontrib>Kumamaru, Kanako K.</creatorcontrib><creatorcontrib>Minamino, Tohru</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><title>Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>Objectives
Vorticity calculated using computational fluid dynamics (CFD) could assess the flow disturbance generated by coronary stenosis. The purpose of this study was to investigate whether vorticity would be an underlying cause of functionally significant stenosis assessed by invasive fractional flow reserve (FFR).
Methods
This retrospective study included 113 patients who underwent coronary CT angiography showing intermediate stenosis and subsequent invasive FFR between December 2015 and March 2020. Vorticity at the stenosis site was calculated using a mesh-free CFD method. We also evaluated the minimum lumen area (MLA) and diameter stenosis (DS) of the lesion. Invasive FFR of ≤ 0.80 was considered functionally significant. Data were compared using Student’s
t
-test and logistic regression analysis was performed.
Results
Of the evaluated 144 vessels, 53 vessels (37%) showed FFR ≤ 0.80. Vorticity of significant stenosis was significantly higher than non-significant stenosis (569 ± 78 vs. 328 ± 34 s
−1
,
p
< 0.001). A significant negative relationship was present between vorticity and invasive FFR (
R
2
= 0.31,
p
< 0.001). Multivariate logistic regression analysis including MLA and DS showed that vorticity (per 100 s
−1
, odds ratio: 1.36, 95% confidence interval: 1.21–1.57,
p
< 0.001) was a statistically significant factor to detect functional significance. The area under the receiver operating characteristic curve statistically significantly increased when vorticity was combined with DS and MLA (0.76 vs. 0.87,
p
= 0.001).
Conclusions
Vorticity had a statistically significant negative relationship with invasive FFR independent of geometric stenosis.
Key Points
• Flow disturbance caused by coronary stenosis could be evaluated by calculating vorticity which is defined as the norm of the rotation of the velocity vector.
• Vorticity was statistically significantly higher in stenosis with functional significance than stenosis without.
• Vorticity has an additive value to detect functionally significant stenosis over geometrical stenosis.</description><subject>Angiography</subject><subject>Cardiac</subject><subject>Computational fluid dynamics</subject><subject>Computer applications</subject><subject>Confidence intervals</subject><subject>Diagnostic Radiology</subject><subject>Evaluation</subject><subject>Fluid dynamics</subject><subject>Hydrodynamics</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Mathematical analysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meshless methods</subject><subject>Neuroradiology</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Stenosis</subject><subject>Ultrasound</subject><subject>Vorticity</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1LxDAQhosouK7-AU8BL16qk49u0qMsfsGCFz2HNE2WLN1mzbRK_73RFRQPwkCG8LwvzFMU5xSuKIC8RgDOoQTGSlC1FCU7KGZUcFZSUOLw135cnCBuAKCmQs4KvYwp9iZNxHfxnbQBhzE1preOGESXpyXNRN5iGoINw5R_iSHWjOhI9MSPvR1CLui6iWBY98EHa_qB4OD6iAFPiyNvOnRn3--8eLm7fV4-lKun-8flzaq0gqqhpEJVprG8BkGlag1IzrmyXEnawIJ6Llztq5Y66m0rhWoct41svZKKVda0fF5c7nt3Kb6ODge9DWhd15nexRE1WygB9aKuREYv_qCbOKZ8QqYkFbQGBjRTbE_ZFBGT83qXwjaL0hT0p3O9d66zc_3lXLMc4vsQZrhfu_RT_U_qA81thRQ</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Tomizawa, Nobuo</creator><creator>Nozaki, Yui</creator><creator>Fujimoto, Shinichiro</creator><creator>Takahashi, Daigo</creator><creator>Kudo, Ayako</creator><creator>Kamo, Yuki</creator><creator>Aoshima, Chihiro</creator><creator>Kawaguchi, Yuko</creator><creator>Takamura, Kazuhisa</creator><creator>Hiki, Makoto</creator><creator>Dohi, Tomotaka</creator><creator>Okazaki, Shinya</creator><creator>Kumamaru, Kanako K.</creator><creator>Minamino, Tohru</creator><creator>Aoki, Shigeki</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6305-1081</orcidid></search><sort><creationdate>20221001</creationdate><title>Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis</title><author>Tomizawa, Nobuo ; Nozaki, Yui ; Fujimoto, Shinichiro ; Takahashi, Daigo ; Kudo, Ayako ; Kamo, Yuki ; Aoshima, Chihiro ; Kawaguchi, Yuko ; Takamura, Kazuhisa ; Hiki, Makoto ; Dohi, Tomotaka ; Okazaki, Shinya ; Kumamaru, Kanako K. ; Minamino, Tohru ; Aoki, Shigeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1485abc3904178da073338c3871b061f34e9f5d1e1fcd748be3cb7df87825cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiography</topic><topic>Cardiac</topic><topic>Computational fluid dynamics</topic><topic>Computer applications</topic><topic>Confidence intervals</topic><topic>Diagnostic Radiology</topic><topic>Evaluation</topic><topic>Fluid dynamics</topic><topic>Hydrodynamics</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Mathematical analysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meshless methods</topic><topic>Neuroradiology</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Stenosis</topic><topic>Ultrasound</topic><topic>Vorticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomizawa, Nobuo</creatorcontrib><creatorcontrib>Nozaki, Yui</creatorcontrib><creatorcontrib>Fujimoto, Shinichiro</creatorcontrib><creatorcontrib>Takahashi, Daigo</creatorcontrib><creatorcontrib>Kudo, Ayako</creatorcontrib><creatorcontrib>Kamo, Yuki</creatorcontrib><creatorcontrib>Aoshima, Chihiro</creatorcontrib><creatorcontrib>Kawaguchi, Yuko</creatorcontrib><creatorcontrib>Takamura, Kazuhisa</creatorcontrib><creatorcontrib>Hiki, Makoto</creatorcontrib><creatorcontrib>Dohi, Tomotaka</creatorcontrib><creatorcontrib>Okazaki, Shinya</creatorcontrib><creatorcontrib>Kumamaru, Kanako K.</creatorcontrib><creatorcontrib>Minamino, Tohru</creatorcontrib><creatorcontrib>Aoki, Shigeki</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomizawa, Nobuo</au><au>Nozaki, Yui</au><au>Fujimoto, Shinichiro</au><au>Takahashi, Daigo</au><au>Kudo, Ayako</au><au>Kamo, Yuki</au><au>Aoshima, Chihiro</au><au>Kawaguchi, Yuko</au><au>Takamura, Kazuhisa</au><au>Hiki, Makoto</au><au>Dohi, Tomotaka</au><au>Okazaki, Shinya</au><au>Kumamaru, Kanako K.</au><au>Minamino, Tohru</au><au>Aoki, Shigeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>32</volume><issue>10</issue><spage>6859</spage><epage>6867</epage><pages>6859-6867</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
Vorticity calculated using computational fluid dynamics (CFD) could assess the flow disturbance generated by coronary stenosis. The purpose of this study was to investigate whether vorticity would be an underlying cause of functionally significant stenosis assessed by invasive fractional flow reserve (FFR).
Methods
This retrospective study included 113 patients who underwent coronary CT angiography showing intermediate stenosis and subsequent invasive FFR between December 2015 and March 2020. Vorticity at the stenosis site was calculated using a mesh-free CFD method. We also evaluated the minimum lumen area (MLA) and diameter stenosis (DS) of the lesion. Invasive FFR of ≤ 0.80 was considered functionally significant. Data were compared using Student’s
t
-test and logistic regression analysis was performed.
Results
Of the evaluated 144 vessels, 53 vessels (37%) showed FFR ≤ 0.80. Vorticity of significant stenosis was significantly higher than non-significant stenosis (569 ± 78 vs. 328 ± 34 s
−1
,
p
< 0.001). A significant negative relationship was present between vorticity and invasive FFR (
R
2
= 0.31,
p
< 0.001). Multivariate logistic regression analysis including MLA and DS showed that vorticity (per 100 s
−1
, odds ratio: 1.36, 95% confidence interval: 1.21–1.57,
p
< 0.001) was a statistically significant factor to detect functional significance. The area under the receiver operating characteristic curve statistically significantly increased when vorticity was combined with DS and MLA (0.76 vs. 0.87,
p
= 0.001).
Conclusions
Vorticity had a statistically significant negative relationship with invasive FFR independent of geometric stenosis.
Key Points
• Flow disturbance caused by coronary stenosis could be evaluated by calculating vorticity which is defined as the norm of the rotation of the velocity vector.
• Vorticity was statistically significantly higher in stenosis with functional significance than stenosis without.
• Vorticity has an additive value to detect functionally significant stenosis over geometrical stenosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00330-022-08974-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6305-1081</orcidid></addata></record> |
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| ispartof | European radiology, 2022-10, Vol.32 (10), p.6859-6867 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2684096954 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Angiography Cardiac Computational fluid dynamics Computer applications Confidence intervals Diagnostic Radiology Evaluation Fluid dynamics Hydrodynamics Imaging Internal Medicine Interventional Radiology Mathematical analysis Medicine Medicine & Public Health Meshless methods Neuroradiology Radiology Regression analysis Statistical analysis Statistical significance Stenosis Ultrasound Vorticity |
| title | Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis |
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