Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians

Several polygenic risk scores (PRSs) have been developed to predict the risk of colorectal cancer (CRC) in European descendants. We used genome‐wide association study (GWAS) data from 22 702 cases and 212 486 controls of Asian ancestry to develop PRSs and validated them in two case‐control studies (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of cancer 2022-11, Vol.151 (10), p.1726-1736
Hauptverfasser:	Ping, Jie, Yang, Yaohua, Wen, Wanqing, Kweon, Sun‐Seog, Matsuda, Koichi, Jia, Wei‐Hua, Shin, Aesun, Gao, Yu‐Tang, Matsuo, Keitaro, Kim, Jeongseon, Kim, Dong‐Hyun, Jee, Sun Ha, Cai, Qiuyin, Chen, Zhishan, Tao, Ran, Shin, Min‐Ho, Tanikawa, Chizu, Pan, Zhi‐Zhong, Oh, Jae Hwan, Oze, Isao, Ahn, Yoon‐Ok, Jung, Keum Ji, Ren, Zefang, Shu, Xiao‐Ou, Long, Jirong, Zheng, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Algorithms Asian people Asian People - genetics Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics East Asian Gene mapping Genetic Predisposition to Disease genetic risk score Genome-Wide Association Study Genomes Humans Medical research Polymorphism, Single Nucleotide Prediction models Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!