Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

[Display omitted] Micronized drug powders are generally unsuitable as tableting feed to produce minitablets due to their cohesivity and poor flow. The silicification of fine paracetamol powder (PCMF) with an optimal concentration range of fumed silica (fSi) [0.7–0.9%, w/w] reduced the net negative c...

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Veröffentlicht in:	International journal of pharmaceutics 2022-07, Vol.623, p.121965-121965, Article 121965
Hauptverfasser:	Loo, Shang Jun, Heng, Paul Wan Sia, Chan, Lai Wah
Format:	Artikel
Sprache:	eng
Schlagworte:	Charge Diminutive granules Flowability Fluid bed granulation High drug load Minitablets
Online-Zugang:	Volltext
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