Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche
Purpose Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarch...
Gespeichert in:
| Veröffentlicht in: | Journal of endocrinological investigation 2022-11, Vol.45 (11), p.2097-2103 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2103 |
|---|---|
| container_issue | 11 |
| container_start_page | 2097 |
| container_title | Journal of endocrinological investigation |
| container_volume | 45 |
| creator | Almasi, N. Zengin, H. Y. Koç, N. Uçakturk, S. A. İskender Mazman, D. Heidarzadeh Rad, N. Fisunoglu, M. |
| description | Purpose
Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT).
Methods
We enrolled 44 girls aged 4–8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected.
Results
Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (
p
|
| doi_str_mv | 10.1007/s40618-022-01841-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2682256642</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2719732681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-ad935fbf6c63fb2e6c63a3eedc753572c97e4711647ec2f622ce021c8c57cb6a3</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0EEqXwBzhZ4sIBg71O7PRYVbykSlzgwMly3U2TKi_shMe_xyVIIA6cdnb1zWg1hJwKfik411ch4UpkjAMwLrJEMLlHJkIDZ5nM1P4vfUiOQthyLrXM9IQ8L7Hry-aCbgqP1U40GHIbT0xcUNusaevxPW5z2lU21JZW-IpVoGVDN6WP4q3sC9p5rG0_eKR9gZX1rsBjcpDbKuDJ95ySp5vrx8UdWz7c3i_mS-ZkCj2z65lM81WunJL5CnA3rURcO53KVIObaUy0ECrR6CBXAA45CJe5VLuVsnJKzsfczrcvA4be1GVwWFW2wXYIBlQGkCqVQETP_qDbdvBN_M6AFjMtIysiBSPlfBuCx9x0vqyt_zCCm13bZmzbxLbNV9tGRpMcTSHCzQb9T_Q_rk9z2YGz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2719732681</pqid></control><display><type>article</type><title>Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche</title><source>SpringerNature Journals</source><creator>Almasi, N. ; Zengin, H. Y. ; Koç, N. ; Uçakturk, S. A. ; İskender Mazman, D. ; Heidarzadeh Rad, N. ; Fisunoglu, M.</creator><creatorcontrib>Almasi, N. ; Zengin, H. Y. ; Koç, N. ; Uçakturk, S. A. ; İskender Mazman, D. ; Heidarzadeh Rad, N. ; Fisunoglu, M.</creatorcontrib><description>Purpose
Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT).
Methods
We enrolled 44 girls aged 4–8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected.
Results
Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (
p
< 0.05). Serum leptin (
p
< 0.001), nesfatin-1 (
p
= 0.001), and orxein-A (
p
< 0.001) levels were significantly higher in the PT group than in healthy controls. However, there were no significant differences in the serum ghrelin levels between the groups (
p
> 0.05). The results of multivariate logistic regression revealed that serum leptin level (OR (95% CI): 42.0 (10.91, 173.06),
p
< 0.001), orexin-A (OR (95% CI): 1.14 (1.04, 1.24),
p
= 0.006), and BMI for age z-score (OR (95% CI): 6.97 (1.47, 33.4),
p
= 0.014) elevated the risk of incidence of PT at 4–8 girls.
Conclusion
These results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-022-01841-3</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Appetite ; Body fat ; Body mass index ; Body weight ; Endocrinology ; Ghrelin ; Health care ; Internal Medicine ; Leptin ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic rate ; Orexins ; Original Article ; Plasma levels ; Puberty ; Public health ; Serum levels</subject><ispartof>Journal of endocrinological investigation, 2022-11, Vol.45 (11), p.2097-2103</ispartof><rights>The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2022</rights><rights>The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-ad935fbf6c63fb2e6c63a3eedc753572c97e4711647ec2f622ce021c8c57cb6a3</citedby><cites>FETCH-LOGICAL-c352t-ad935fbf6c63fb2e6c63a3eedc753572c97e4711647ec2f622ce021c8c57cb6a3</cites><orcidid>0000-0002-0021-7811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-022-01841-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-022-01841-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Almasi, N.</creatorcontrib><creatorcontrib>Zengin, H. Y.</creatorcontrib><creatorcontrib>Koç, N.</creatorcontrib><creatorcontrib>Uçakturk, S. A.</creatorcontrib><creatorcontrib>İskender Mazman, D.</creatorcontrib><creatorcontrib>Heidarzadeh Rad, N.</creatorcontrib><creatorcontrib>Fisunoglu, M.</creatorcontrib><title>Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT).
Methods
We enrolled 44 girls aged 4–8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected.
Results
Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (
p
< 0.05). Serum leptin (
p
< 0.001), nesfatin-1 (
p
= 0.001), and orxein-A (
p
< 0.001) levels were significantly higher in the PT group than in healthy controls. However, there were no significant differences in the serum ghrelin levels between the groups (
p
> 0.05). The results of multivariate logistic regression revealed that serum leptin level (OR (95% CI): 42.0 (10.91, 173.06),
p
< 0.001), orexin-A (OR (95% CI): 1.14 (1.04, 1.24),
p
= 0.006), and BMI for age z-score (OR (95% CI): 6.97 (1.47, 33.4),
p
= 0.014) elevated the risk of incidence of PT at 4–8 girls.
Conclusion
These results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies.</description><subject>Appetite</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Endocrinology</subject><subject>Ghrelin</subject><subject>Health care</subject><subject>Internal Medicine</subject><subject>Leptin</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic rate</subject><subject>Orexins</subject><subject>Original Article</subject><subject>Plasma levels</subject><subject>Puberty</subject><subject>Public health</subject><subject>Serum levels</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EEqXwBzhZ4sIBg71O7PRYVbykSlzgwMly3U2TKi_shMe_xyVIIA6cdnb1zWg1hJwKfik411ch4UpkjAMwLrJEMLlHJkIDZ5nM1P4vfUiOQthyLrXM9IQ8L7Hry-aCbgqP1U40GHIbT0xcUNusaevxPW5z2lU21JZW-IpVoGVDN6WP4q3sC9p5rG0_eKR9gZX1rsBjcpDbKuDJ95ySp5vrx8UdWz7c3i_mS-ZkCj2z65lM81WunJL5CnA3rURcO53KVIObaUy0ECrR6CBXAA45CJe5VLuVsnJKzsfczrcvA4be1GVwWFW2wXYIBlQGkCqVQETP_qDbdvBN_M6AFjMtIysiBSPlfBuCx9x0vqyt_zCCm13bZmzbxLbNV9tGRpMcTSHCzQb9T_Q_rk9z2YGz</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Almasi, N.</creator><creator>Zengin, H. Y.</creator><creator>Koç, N.</creator><creator>Uçakturk, S. A.</creator><creator>İskender Mazman, D.</creator><creator>Heidarzadeh Rad, N.</creator><creator>Fisunoglu, M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0021-7811</orcidid></search><sort><creationdate>20221101</creationdate><title>Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche</title><author>Almasi, N. ; Zengin, H. Y. ; Koç, N. ; Uçakturk, S. A. ; İskender Mazman, D. ; Heidarzadeh Rad, N. ; Fisunoglu, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-ad935fbf6c63fb2e6c63a3eedc753572c97e4711647ec2f622ce021c8c57cb6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Appetite</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Endocrinology</topic><topic>Ghrelin</topic><topic>Health care</topic><topic>Internal Medicine</topic><topic>Leptin</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic rate</topic><topic>Orexins</topic><topic>Original Article</topic><topic>Plasma levels</topic><topic>Puberty</topic><topic>Public health</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almasi, N.</creatorcontrib><creatorcontrib>Zengin, H. Y.</creatorcontrib><creatorcontrib>Koç, N.</creatorcontrib><creatorcontrib>Uçakturk, S. A.</creatorcontrib><creatorcontrib>İskender Mazman, D.</creatorcontrib><creatorcontrib>Heidarzadeh Rad, N.</creatorcontrib><creatorcontrib>Fisunoglu, M.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almasi, N.</au><au>Zengin, H. Y.</au><au>Koç, N.</au><au>Uçakturk, S. A.</au><au>İskender Mazman, D.</au><au>Heidarzadeh Rad, N.</au><au>Fisunoglu, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><date>2022-11-01</date><risdate>2022</risdate><volume>45</volume><issue>11</issue><spage>2097</spage><epage>2103</epage><pages>2097-2103</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Reducing the mean age of puberty onset in recent years has crucial public health, clinical, and social implications. This study aimed to evaluate the serum levels of appetite-related peptides (leptin, ghrelin, nesfatin-1, and orexin-A) and anthropometric data in girls with premature thelarche (PT).
Methods
We enrolled 44 girls aged 4–8 years diagnosed with PT and 33 age-matched healthy girls as controls. The demographic data of the girls were obtained using a questionnaire. Anthropometric data were measured and fasting blood samples were collected.
Results
Body weight, height, body mass index (BMI), body fat mass, and basal metabolic rate (BMR) were higher in the PT group than in the control group (
p
< 0.05). Serum leptin (
p
< 0.001), nesfatin-1 (
p
= 0.001), and orxein-A (
p
< 0.001) levels were significantly higher in the PT group than in healthy controls. However, there were no significant differences in the serum ghrelin levels between the groups (
p
> 0.05). The results of multivariate logistic regression revealed that serum leptin level (OR (95% CI): 42.0 (10.91, 173.06),
p
< 0.001), orexin-A (OR (95% CI): 1.14 (1.04, 1.24),
p
= 0.006), and BMI for age z-score (OR (95% CI): 6.97 (1.47, 33.4),
p
= 0.014) elevated the risk of incidence of PT at 4–8 girls.
Conclusion
These results suggest that in addition to serum leptin levels, serum orexin-A and nesaftin-1 can take part in the initiation of PT. Few studies have investigated the relationship between nesfatin-1 and orexin-A levels and age at onset of puberty; hence, it should be a subject for future studies.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s40618-022-01841-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0021-7811</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8386 |
| ispartof | Journal of endocrinological investigation, 2022-11, Vol.45 (11), p.2097-2103 |
| issn | 1720-8386 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2682256642 |
| source | SpringerNature Journals |
| subjects | Appetite Body fat Body mass index Body weight Endocrinology Ghrelin Health care Internal Medicine Leptin Medicine Medicine & Public Health Metabolic Diseases Metabolic rate Orexins Original Article Plasma levels Puberty Public health Serum levels |
| title | Leptin, ghrelin, nesfatin-1, and orexin-A plasma levels in girls with premature thelarche |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A14%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leptin,%20ghrelin,%20nesfatin-1,%20and%20orexin-A%20plasma%20levels%20in%20girls%20with%20premature%20thelarche&rft.jtitle=Journal%20of%20endocrinological%20investigation&rft.au=Almasi,%20N.&rft.date=2022-11-01&rft.volume=45&rft.issue=11&rft.spage=2097&rft.epage=2103&rft.pages=2097-2103&rft.issn=1720-8386&rft.eissn=1720-8386&rft_id=info:doi/10.1007/s40618-022-01841-3&rft_dat=%3Cproquest_cross%3E2719732681%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2719732681&rft_id=info:pmid/&rfr_iscdi=true |