TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway

The dynamics of mitochondrial biogenesis regulation is critical in maintaining cellular homeostasis for immune regulation and tumor prevention. Here, we report that mitochondrial biogenesis disruption through TFAM reduction significantly impairs mitochondrial function, induces autophagy, and promote...

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Veröffentlicht in:	Oncogene 2022-07, Vol.41 (30), p.3735-3746
Hauptverfasser:	Li, Yujia, Yang, Qi, Chen, Hui, Yang, Xiaotian, Han, Jingru, Yao, Xiaojuan, Wei, Xiajie, Si, Jiaoyang, Yao, Huanling, Liu, Hongliang, Wan, Lixin, Yang, Hushan, Wang, Yanming, Bao, Dengke
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 14/19 14/28 38 38/91 631/67/395 631/80 82 96 96/1 Apoptosis Autophagy Biosynthesis Cell Biology Cellular stress response Cytosol Deoxyribonuclease Esophageal cancer Homeostasis Human Genetics Immunoregulation Internal Medicine Medicine Medicine & Public Health Mitochondrial DNA Oncology Signal transduction Squamous cell carcinoma Tumors
Online-Zugang:	Volltext
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