A Chimeric Conjugate of Antibody and Programmable DNA Nanoassembly Smartly Activates T Cells for Precise Cancer Cell Targeting

Synthetically directing T‐cells against tumors emerges as a promising strategy in immunotherapy, while it remains challenging to smartly engage T cells with tunable immune response. Herein, we report an intelligent molecular platform to engineer T‐cell recognition for selective activation to potentl...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-09, Vol.61 (36), p.e202205902-n/a
Hauptverfasser:	Tang, Rui, Fu, Yu‐Hao, Gong, Bo, Fan, Ying‐Ying, Wang, Hong‐Hui, Huang, Yan, Nie, Zhou, Wei, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Aptamers Avidity Cancer Cancer Immunotherapy Cell activation Cell recognition Circuits Combinatorial analysis Conjugates Conjugation Deoxyribonucleic acid DNA DNA Nanoassembly DNA–Protein Conjugation Immune response Immune system Immunotherapy Logic Operation Lymphocytes Lymphocytes T Programmable DNA Circuit Recognition Tumors
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