Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual g...

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Veröffentlicht in:	The New England journal of medicine 2022-07, Vol.387 (1), p.35-44
Hauptverfasser:	Griffith, Bartley P., Goerlich, Corbin E., Singh, Avneesh K., Rothblatt, Martine, Lau, Christine L., Shah, Aakash, Lorber, Marc, Grazioli, Alison, Saharia, Kapil K., Hong, Susie N., Joseph, Susan M., Ayares, David, Mohiuddin, Muhammad M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animals Animals, Genetically Modified - genetics Autopsy Blood pressure Cardiology Cardiology General Cardiomyopathy CD40 antigen Consent Drug dosages Edema Ethical and Legal Issues Extracorporeal Membrane Oxygenation Extravasation Gene Editing Genetics Genetics General Graft rejection Heart Heart failure Heart Transplantation Heart Transplantation - methods Heart transplants Heterografts Humans Immunity Immunosuppression Immunosuppression Therapy Infectious Disease Infectious Disease General Ischemia Laboratories Leukopenia Medical Ethics Microvasculature Monoclonal antibodies Myocytes Oxygenation Pathogens Proteins Research Ethics Surgery Surveillance Swine Thrombocytopenia Thrombosis Transplantation Transplantation, Heterologous - methods Transplants & implants Xenografts
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