Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia
Background Non‐severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy. Methods Retrospectively analyzed 32 patients with non‐severe aplastic a...
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| Veröffentlicht in: | Pediatric transplantation 2022-11, Vol.26 (7), p.e14340-n/a |
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| container_title | Pediatric transplantation |
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| creator | Zhang, Man Zhu, Guanghua Cai, Lixiao Yuan, Meng Wu, Runhui Jia, Chenguang Wang, Bin Zheng, Jie Ma, Jie Qin, Maoquan Li, Sidan |
| description | Background
Non‐severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy.
Methods
Retrospectively analyzed 32 patients with non‐severe aplastic anemia who underwent hematopoietic stem cell transplantation from September 2007 to September 2020, and the 5‐year estimated overall survival rate and the incidence of graft‐versus‐host disease were analyzed to evaluate the efficacy and safety of hematopoietic stem cell transplantation in the treatment of pediatric non‐severe aplastic anemia.
Results
Thirty‐two patients who underwent transplantation, 29 patients (90.6%) survived, 3 patients (9.4%) died. The incidence of acute graft‐versus‐host disease was 51.6% (16/31), including 15 cases (48.4%) of grade I‐II and 1 case (3.2%) of grade III–IV. The incidence of chronic graft‐versus‐host disease was 38.7% (12/31). The 5‐year overall survival rate was 91.8%.
Conclusions
Hematopoietic stem cell transplantation is a practicable, safe, and effective treatment option for non‐severe aplastic anemia pediatric patients who are suitable for transplant. |
| doi_str_mv | 10.1111/petr.14340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2680236592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2723334389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3340-a700f01f498318229f59a50b5ec49b0ea72b8b707f5ffd22b220b4012f1949e33</originalsourceid><addsrcrecordid>eNp9kM9KxDAQxosoqKsXnyDgRYSu-ddtc5Rl_QMLiug5pHXCRtqkJlmXvfkIPqNPYrr15MG5zDD8vuGbL8vOCJ6SVFc9RD8lnHG8lx0RJkTOMJ_t7-YyZ4TTw-w4hDeMyYxX_CjzC61No5otchqtoFPR9c5ANA0KETrUQNui6JUNfatsVNE4i4xFcQVpDSp2YOOgbVamffVg0cbEFbLOfn9-BfgAD0glaRguKgudUSfZgVZtgNPfPslebhbP87t8-XB7P79e5g1L_nNVYqwx0VxUjFSUCl0IVeC6gIaLGoMqaV3VJS51ofUrpTWluOaYUE0EF8DYJLsY7_beva8hRNmZMPyTbLh1kHRWYcpmhaAJPf-Dvrm1t8mdpCVlyQ-rRKIuR6rxLgQPWvbedMpvJcFyiF8O8ctd_AkmI7wxLWz_IeXj4vlp1PwAEFaJbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2723334389</pqid></control><display><type>article</type><title>Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhang, Man ; Zhu, Guanghua ; Cai, Lixiao ; Yuan, Meng ; Wu, Runhui ; Jia, Chenguang ; Wang, Bin ; Zheng, Jie ; Ma, Jie ; Qin, Maoquan ; Li, Sidan</creator><creatorcontrib>Zhang, Man ; Zhu, Guanghua ; Cai, Lixiao ; Yuan, Meng ; Wu, Runhui ; Jia, Chenguang ; Wang, Bin ; Zheng, Jie ; Ma, Jie ; Qin, Maoquan ; Li, Sidan</creatorcontrib><description>Background
Non‐severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy.
Methods
Retrospectively analyzed 32 patients with non‐severe aplastic anemia who underwent hematopoietic stem cell transplantation from September 2007 to September 2020, and the 5‐year estimated overall survival rate and the incidence of graft‐versus‐host disease were analyzed to evaluate the efficacy and safety of hematopoietic stem cell transplantation in the treatment of pediatric non‐severe aplastic anemia.
Results
Thirty‐two patients who underwent transplantation, 29 patients (90.6%) survived, 3 patients (9.4%) died. The incidence of acute graft‐versus‐host disease was 51.6% (16/31), including 15 cases (48.4%) of grade I‐II and 1 case (3.2%) of grade III–IV. The incidence of chronic graft‐versus‐host disease was 38.7% (12/31). The 5‐year overall survival rate was 91.8%.
Conclusions
Hematopoietic stem cell transplantation is a practicable, safe, and effective treatment option for non‐severe aplastic anemia pediatric patients who are suitable for transplant.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.14340</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Anemia ; Aplastic anemia ; children ; hematopoietic stem cell transplantation ; Hematopoietic stem cells ; non‐severe aplastic anemia ; Patients ; Pediatrics ; Stem cell transplantation</subject><ispartof>Pediatric transplantation, 2022-11, Vol.26 (7), p.e14340-n/a</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2022 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3340-a700f01f498318229f59a50b5ec49b0ea72b8b707f5ffd22b220b4012f1949e33</citedby><cites>FETCH-LOGICAL-c3340-a700f01f498318229f59a50b5ec49b0ea72b8b707f5ffd22b220b4012f1949e33</cites><orcidid>0000-0002-4299-3827 ; 0000-0003-2704-8592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.14340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.14340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Zhu, Guanghua</creatorcontrib><creatorcontrib>Cai, Lixiao</creatorcontrib><creatorcontrib>Yuan, Meng</creatorcontrib><creatorcontrib>Wu, Runhui</creatorcontrib><creatorcontrib>Jia, Chenguang</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Qin, Maoquan</creatorcontrib><creatorcontrib>Li, Sidan</creatorcontrib><title>Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia</title><title>Pediatric transplantation</title><description>Background
Non‐severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy.
Methods
Retrospectively analyzed 32 patients with non‐severe aplastic anemia who underwent hematopoietic stem cell transplantation from September 2007 to September 2020, and the 5‐year estimated overall survival rate and the incidence of graft‐versus‐host disease were analyzed to evaluate the efficacy and safety of hematopoietic stem cell transplantation in the treatment of pediatric non‐severe aplastic anemia.
Results
Thirty‐two patients who underwent transplantation, 29 patients (90.6%) survived, 3 patients (9.4%) died. The incidence of acute graft‐versus‐host disease was 51.6% (16/31), including 15 cases (48.4%) of grade I‐II and 1 case (3.2%) of grade III–IV. The incidence of chronic graft‐versus‐host disease was 38.7% (12/31). The 5‐year overall survival rate was 91.8%.
Conclusions
Hematopoietic stem cell transplantation is a practicable, safe, and effective treatment option for non‐severe aplastic anemia pediatric patients who are suitable for transplant.</description><subject>Anemia</subject><subject>Aplastic anemia</subject><subject>children</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic stem cells</subject><subject>non‐severe aplastic anemia</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Stem cell transplantation</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM9KxDAQxosoqKsXnyDgRYSu-ddtc5Rl_QMLiug5pHXCRtqkJlmXvfkIPqNPYrr15MG5zDD8vuGbL8vOCJ6SVFc9RD8lnHG8lx0RJkTOMJ_t7-YyZ4TTw-w4hDeMyYxX_CjzC61No5otchqtoFPR9c5ANA0KETrUQNui6JUNfatsVNE4i4xFcQVpDSp2YOOgbVamffVg0cbEFbLOfn9-BfgAD0glaRguKgudUSfZgVZtgNPfPslebhbP87t8-XB7P79e5g1L_nNVYqwx0VxUjFSUCl0IVeC6gIaLGoMqaV3VJS51ofUrpTWluOaYUE0EF8DYJLsY7_beva8hRNmZMPyTbLh1kHRWYcpmhaAJPf-Dvrm1t8mdpCVlyQ-rRKIuR6rxLgQPWvbedMpvJcFyiF8O8ctd_AkmI7wxLWz_IeXj4vlp1PwAEFaJbQ</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Zhang, Man</creator><creator>Zhu, Guanghua</creator><creator>Cai, Lixiao</creator><creator>Yuan, Meng</creator><creator>Wu, Runhui</creator><creator>Jia, Chenguang</creator><creator>Wang, Bin</creator><creator>Zheng, Jie</creator><creator>Ma, Jie</creator><creator>Qin, Maoquan</creator><creator>Li, Sidan</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4299-3827</orcidid><orcidid>https://orcid.org/0000-0003-2704-8592</orcidid></search><sort><creationdate>202211</creationdate><title>Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia</title><author>Zhang, Man ; Zhu, Guanghua ; Cai, Lixiao ; Yuan, Meng ; Wu, Runhui ; Jia, Chenguang ; Wang, Bin ; Zheng, Jie ; Ma, Jie ; Qin, Maoquan ; Li, Sidan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3340-a700f01f498318229f59a50b5ec49b0ea72b8b707f5ffd22b220b4012f1949e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anemia</topic><topic>Aplastic anemia</topic><topic>children</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic stem cells</topic><topic>non‐severe aplastic anemia</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Stem cell transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Zhu, Guanghua</creatorcontrib><creatorcontrib>Cai, Lixiao</creatorcontrib><creatorcontrib>Yuan, Meng</creatorcontrib><creatorcontrib>Wu, Runhui</creatorcontrib><creatorcontrib>Jia, Chenguang</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Qin, Maoquan</creatorcontrib><creatorcontrib>Li, Sidan</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Man</au><au>Zhu, Guanghua</au><au>Cai, Lixiao</au><au>Yuan, Meng</au><au>Wu, Runhui</au><au>Jia, Chenguang</au><au>Wang, Bin</au><au>Zheng, Jie</au><au>Ma, Jie</au><au>Qin, Maoquan</au><au>Li, Sidan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia</atitle><jtitle>Pediatric transplantation</jtitle><date>2022-11</date><risdate>2022</risdate><volume>26</volume><issue>7</issue><spage>e14340</spage><epage>n/a</epage><pages>e14340-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Background
Non‐severe aplastic anemia is more likely to develop into severe aplastic anemia, and there is no widely accepted treatment plan at present. Hematopoietic stem cell transplantation might be a new therapeutic strategy.
Methods
Retrospectively analyzed 32 patients with non‐severe aplastic anemia who underwent hematopoietic stem cell transplantation from September 2007 to September 2020, and the 5‐year estimated overall survival rate and the incidence of graft‐versus‐host disease were analyzed to evaluate the efficacy and safety of hematopoietic stem cell transplantation in the treatment of pediatric non‐severe aplastic anemia.
Results
Thirty‐two patients who underwent transplantation, 29 patients (90.6%) survived, 3 patients (9.4%) died. The incidence of acute graft‐versus‐host disease was 51.6% (16/31), including 15 cases (48.4%) of grade I‐II and 1 case (3.2%) of grade III–IV. The incidence of chronic graft‐versus‐host disease was 38.7% (12/31). The 5‐year overall survival rate was 91.8%.
Conclusions
Hematopoietic stem cell transplantation is a practicable, safe, and effective treatment option for non‐severe aplastic anemia pediatric patients who are suitable for transplant.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/petr.14340</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4299-3827</orcidid><orcidid>https://orcid.org/0000-0003-2704-8592</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anemia Aplastic anemia children hematopoietic stem cell transplantation Hematopoietic stem cells non‐severe aplastic anemia Patients Pediatrics Stem cell transplantation |
| title | Efficacy of hematopoietic stem cell transplantation in the treatment of children with non‐severe aplastic anemia |
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