Dopamine Negatively Regulates Insulin Secretion Through Activation of D1-D2 Receptor Heteromer

There is increasing evidence that dopamine (DA) functions as a negative regulator of glucose-stimulated insulin secretion; however, the underlying molecular mechanism remains unknown. Using total internal reflection fluorescence microscopy, we monitored insulin granule exocytosis in primary islet ce...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-09, Vol.71 (9), p.1946-1961
Hauptverfasser:	Uefune, Fumiya, Aonishi, Toru, Kitaguchi, Tetsuya, Takahashi, Harumi, Seino, Susumu, Sakano, Daisuke, Kume, Shoen
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells Calcium influx Diabetes Diabetes mellitus Dopamine Dopamine D1 receptors Dopamine D2 receptors Exocytosis Fluorescence microscopy Glucose Insulin Insulin secretion Islet cells Secretion
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