Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice

Arctigenin (Arc) is a phenylpropanoid dibenzylbutyrolactone lignan in Arctium lappa L , which has been widely applied as a traditional Chinese herbal medicine for treating inflammation. In the present study, we explored the neuroprotective effect and the potential mechanisms of arctigenin against LP...

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Veröffentlicht in:	Metabolic brain disease 2022-08, Vol.37 (6), p.2039-2052
Hauptverfasser:	Yuan, Quan, Wu, Yiran, Wang, Gang, Zhou, Xiang, Dong, Xiaohui, Lou, Zihan, Li, Sanqiang, Wang, Dongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Alzheimer's disease Amyloid precursor protein Amyloidogenesis Apoptosis Arctium lappa Biochemistry Biomedical and Life Sciences Biomedicine CD14 antigen Cell activation Cognitive ability Cytokines Herbal medicine Inflammation Inflammatory response Injury prevention Lignans Lipopolysaccharides Memory Metabolic Diseases Microglial cells Neurodegeneration Neurology Neuroprotection Neurosciences NF-κB protein Oncology Original Article Precursors Proteins Signal transduction Spatial discrimination learning Spatial memory TLR4 protein Toll-like receptors β-Site APP-cleaving enzyme 1
Online-Zugang:	Volltext
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