Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility
Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard‐segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard‐segment‐content SPEU materia...
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| Veröffentlicht in: | Journal of biomedical materials research 1998-09, Vol.41 (4), p.633-648 |
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| creator | Chen, Jui-Hsiang Wei, Jeng Chang, Chung-Yi Laiw, Ru-Fong Lee, Yu-Der |
| description | Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard‐segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard‐segment‐content SPEU material possesses a lower contact angle, implying that the surface of the higher hard‐segment‐content SPEU is more hydrophilic than its low hard‐segment‐content SPEU counterpart. The catalyst‐ and additive‐free PTMO‐based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L‐929 cell lines, a cell‐seeding test indicated that the higher hard‐segment‐content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard‐segment‐content SPEU possesses less platelet adhesion than the high hard‐segment‐content SPEU material. Both ex vivo canine artery–artery (A‐A) and arterio–venous (A‐V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard‐segment‐content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by nearly the same levels as the hard‐segment‐content SPEU. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 633–648, 1998. |
| doi_str_mv | 10.1002/(SICI)1097-4636(19980915)41:4<633::AID-JBM16>3.0.CO;2-F |
| format | Article |
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The static contact angle data reveal that the higher hard‐segment‐content SPEU material possesses a lower contact angle, implying that the surface of the higher hard‐segment‐content SPEU is more hydrophilic than its low hard‐segment‐content SPEU counterpart. The catalyst‐ and additive‐free PTMO‐based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L‐929 cell lines, a cell‐seeding test indicated that the higher hard‐segment‐content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard‐segment‐content SPEU possesses less platelet adhesion than the high hard‐segment‐content SPEU material. Both ex vivo canine artery–artery (A‐A) and arterio–venous (A‐V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard‐segment‐content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by nearly the same levels as the hard‐segment‐content SPEU. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 633–648, 1998.</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/(SICI)1097-4636(19980915)41:4<633::AID-JBM16>3.0.CO;2-F</identifier><identifier>PMID: 9697037</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adhesion ; Animals ; Biocompatibility ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Blood ; blood compatibility ; Blood Platelets - cytology ; Cell Adhesion ; Cell culture ; Cell Line ; Cell Survival ; Cells ; Composition ; Contact angle ; cytotoxicity ; Dogs ; hemolysis ; Materials testing ; Medical applications ; Medical sciences ; Mice ; Polyurethanes - chemistry ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; segmented polyetherurethane (SPEU) ; Synthesis (chemical) ; Technology. Biomaterials. Equipments. Material. Instrumentation</subject><ispartof>Journal of biomedical materials research, 1998-09, Vol.41 (4), p.633-648</ispartof><rights>Copyright © 1998 John Wiley & Sons, Inc.</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5936-81f07082a69d8dbef020c2e9c9f5b6f6588624bda173872608401ac210f5e7bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4636%2819980915%2941%3A4%3C633%3A%3AAID-JBM16%3E3.0.CO%3B2-F$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4636%2819980915%2941%3A4%3C633%3A%3AAID-JBM16%3E3.0.CO%3B2-F$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2331446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9697037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jui-Hsiang</creatorcontrib><creatorcontrib>Wei, Jeng</creatorcontrib><creatorcontrib>Chang, Chung-Yi</creatorcontrib><creatorcontrib>Laiw, Ru-Fong</creatorcontrib><creatorcontrib>Lee, Yu-Der</creatorcontrib><title>Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard‐segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard‐segment‐content SPEU material possesses a lower contact angle, implying that the surface of the higher hard‐segment‐content SPEU is more hydrophilic than its low hard‐segment‐content SPEU counterpart. The catalyst‐ and additive‐free PTMO‐based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L‐929 cell lines, a cell‐seeding test indicated that the higher hard‐segment‐content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard‐segment‐content SPEU possesses less platelet adhesion than the high hard‐segment‐content SPEU material. Both ex vivo canine artery–artery (A‐A) and arterio–venous (A‐V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard‐segment‐content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by nearly the same levels as the hard‐segment‐content SPEU. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 633–648, 1998.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>blood compatibility</subject><subject>Blood Platelets - cytology</subject><subject>Cell Adhesion</subject><subject>Cell culture</subject><subject>Cell Line</subject><subject>Cell Survival</subject><subject>Cells</subject><subject>Composition</subject><subject>Contact angle</subject><subject>cytotoxicity</subject><subject>Dogs</subject><subject>hemolysis</subject><subject>Materials testing</subject><subject>Medical applications</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Polyurethanes - chemistry</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>segmented polyetherurethane (SPEU)</subject><subject>Synthesis (chemical)</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAURiMEGkrhEZCyQGhmkeK_2HFBoKFMh0KHLgZUxObKSewZQ5oEOxH0BXhuHFq6Aamra_l-Pr72iaJXGE0wQuTZ6fVitjjDSIqEccpPsZQZkjg9Y3jKXnBKp9PzxZvk3esrzF_SCZrMVs9JMr8TjQ5n7kajQMKJpIjdjx54_xUhJCXFJ9GJ5FIgKkbRr-uuL632cVPHXt9sdN3pMm6baqu7W-16F4qqdWwaF-e22ejSFqqKVdtWYdHZpp7GF8boogsIExfNpm28HfZjVZfxrXJlsueGZoCHGnoBNUQDILeV7bYPo3tGVV4_2tdx9Gl-8XH2NlmuLhez82VSpJLyJMMGCZQRxWWZlbk2iKCCaFlIk-bc8DTLOGF5qbCgmSAcZQxhVRCMTKpFbug4errjtq753mvfwcb6QldVeGPTeyBcSDZ8zdEgpiJlTBwNYs44RgyH4HoXLFzjvdMGWmc3ym0BIxicAwzOYfAHgz_46xwYBgbBOUBwDn-cAwUEsxUQmAfy4_0IfR4EHbh7yaH_ZN9XPsgzTtWF9YcYoRSzcOE4-ryL_bCV3v4z3dHh_jfbbiOgkx3a-k7_PKCV-wZchI-E9YdLWKfyav7lvYAl_Q397eWH</recordid><startdate>19980915</startdate><enddate>19980915</enddate><creator>Chen, Jui-Hsiang</creator><creator>Wei, Jeng</creator><creator>Chang, Chung-Yi</creator><creator>Laiw, Ru-Fong</creator><creator>Lee, Yu-Der</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>JG9</scope></search><sort><creationdate>19980915</creationdate><title>Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility</title><author>Chen, Jui-Hsiang ; Wei, Jeng ; Chang, Chung-Yi ; Laiw, Ru-Fong ; Lee, Yu-Der</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5936-81f07082a69d8dbef020c2e9c9f5b6f6588624bda173872608401ac210f5e7bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>blood compatibility</topic><topic>Blood Platelets - cytology</topic><topic>Cell Adhesion</topic><topic>Cell culture</topic><topic>Cell Line</topic><topic>Cell Survival</topic><topic>Cells</topic><topic>Composition</topic><topic>Contact angle</topic><topic>cytotoxicity</topic><topic>Dogs</topic><topic>hemolysis</topic><topic>Materials testing</topic><topic>Medical applications</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Polyurethanes - chemistry</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>segmented polyetherurethane (SPEU)</topic><topic>Synthesis (chemical)</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jui-Hsiang</creatorcontrib><creatorcontrib>Wei, Jeng</creatorcontrib><creatorcontrib>Chang, Chung-Yi</creatorcontrib><creatorcontrib>Laiw, Ru-Fong</creatorcontrib><creatorcontrib>Lee, Yu-Der</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Research Database</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jui-Hsiang</au><au>Wei, Jeng</au><au>Chang, Chung-Yi</au><au>Laiw, Ru-Fong</au><au>Lee, Yu-Der</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>1998-09-15</date><risdate>1998</risdate><volume>41</volume><issue>4</issue><spage>633</spage><epage>648</epage><pages>633-648</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard‐segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard‐segment‐content SPEU material possesses a lower contact angle, implying that the surface of the higher hard‐segment‐content SPEU is more hydrophilic than its low hard‐segment‐content SPEU counterpart. The catalyst‐ and additive‐free PTMO‐based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L‐929 cell lines, a cell‐seeding test indicated that the higher hard‐segment‐content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard‐segment‐content SPEU possesses less platelet adhesion than the high hard‐segment‐content SPEU material. Both ex vivo canine artery–artery (A‐A) and arterio–venous (A‐V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard‐segment‐content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by nearly the same levels as the hard‐segment‐content SPEU. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 633–648, 1998.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>9697037</pmid><doi>10.1002/(SICI)1097-4636(19980915)41:4<633::AID-JBM16>3.0.CO;2-F</doi><tpages>16</tpages></addata></record> |
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| subjects | Adhesion Animals Biocompatibility Biocompatible Materials - chemistry Biological and medical sciences Blood blood compatibility Blood Platelets - cytology Cell Adhesion Cell culture Cell Line Cell Survival Cells Composition Contact angle cytotoxicity Dogs hemolysis Materials testing Medical applications Medical sciences Mice Polyurethanes - chemistry Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) segmented polyetherurethane (SPEU) Synthesis (chemical) Technology. Biomaterials. Equipments. Material. Instrumentation |
| title | Studies on segmented polyetherurethane for biomedical application: Effects of composition and hard-segment content on biocompatibility |
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