Designing synergistic crystallization inhibitors: Bile salt derivatives of cellulose with enhanced hydrophilicity

Crystallization inhibitors in amorphous solid dispersions (ASD) enable metastable supersaturated drug solutions that persist for a physiologically relevant time. Olefin cross-metathesis (CM) has successfully provided multifunctional cellulose-based derivatives as candidate ASD matrix polymers. In pr...

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Veröffentlicht in:	Carbohydrate polymers 2022-09, Vol.292, p.119680-119680, Article 119680
Hauptverfasser:	Novo, Diana C., Gao, Chengzhe, Qi, Qingqing, Mosquera-Giraldo, Laura I., Spiering, Glenn A., Moore, Robert B., Taylor, Lynne S., Edgar, Kevin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous solid dispersion Bile-salts Cellulose Chemoselectivity Enzalutamide Olefin cross-metathesis
Online-Zugang:	Volltext
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