Carboxymethyl chitosan and carboxymethyl cellulose based self-healing hydrogel for accelerating diabetic wound healing
In this study, a new type of biodegradable, injectable, self-healing, and low-toxic CMCSH, formed by N, O-carboxymethyl chitosan-heparin (CMCS-Hep) and carboxymethyl cellulose-aldehyde (CMC-A), was designed to deliver drug for promoting the progress of the diabetic wound healing. CMCS was modified w...
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| Veröffentlicht in: | Carbohydrate polymers 2022-09, Vol.292, p.119687-119687, Article 119687 |
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| container_title | Carbohydrate polymers |
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| creator | Chang, Guozhu Dang, Qifeng Liu, Chengsheng Wang, Xiaoyu Song, Hao Gao, Hong Sun, Hantian Zhang, Bonian Cha, Dongsu |
| description | In this study, a new type of biodegradable, injectable, self-healing, and low-toxic CMCSH, formed by N, O-carboxymethyl chitosan-heparin (CMCS-Hep) and carboxymethyl cellulose-aldehyde (CMC-A), was designed to deliver drug for promoting the progress of the diabetic wound healing. CMCS was modified with Hep for the first time to synthesize CMCS-Hep, and CMC-A was synthesized by the periodate oxidation method. First, SOD encapsulated in the CMCSH was applied to the diabetic wound bed to moderate the microenvironment, then rhEGF retained in the CMCSH was sustainedly released to the wound area. These results indicated that the dual-drug delivery system had the ability to improve drug availability, promote cell migration and proliferation, reduce DNA damage, shorten the inflammatory period, and accelerate the deposition of collagen fibers and the formation of blood vessels in the model with diabetic skin injury, suggesting that CMCSH as drug carriers had positive effects on diabetic wound healing. |
| doi_str_mv | 10.1016/j.carbpol.2022.119687 |
| format | Article |
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CMCS was modified with Hep for the first time to synthesize CMCS-Hep, and CMC-A was synthesized by the periodate oxidation method. First, SOD encapsulated in the CMCSH was applied to the diabetic wound bed to moderate the microenvironment, then rhEGF retained in the CMCSH was sustainedly released to the wound area. These results indicated that the dual-drug delivery system had the ability to improve drug availability, promote cell migration and proliferation, reduce DNA damage, shorten the inflammatory period, and accelerate the deposition of collagen fibers and the formation of blood vessels in the model with diabetic skin injury, suggesting that CMCSH as drug carriers had positive effects on diabetic wound healing.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2022.119687</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Carboxymethyl cellulose ; Carboxymethyl chitosan ; Control release ; Diabetic wound healing ; Heparin ; Self-healing hydrogel</subject><ispartof>Carbohydrate polymers, 2022-09, Vol.292, p.119687-119687, Article 119687</ispartof><rights>2022 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-6c9d83ff9917ed2923860c25807ac215f3cec8c6b7ad4e1951fdbbbcd6dfd8373</citedby><cites>FETCH-LOGICAL-c342t-6c9d83ff9917ed2923860c25807ac215f3cec8c6b7ad4e1951fdbbbcd6dfd8373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2022.119687$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Chang, Guozhu</creatorcontrib><creatorcontrib>Dang, Qifeng</creatorcontrib><creatorcontrib>Liu, Chengsheng</creatorcontrib><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Song, Hao</creatorcontrib><creatorcontrib>Gao, Hong</creatorcontrib><creatorcontrib>Sun, Hantian</creatorcontrib><creatorcontrib>Zhang, Bonian</creatorcontrib><creatorcontrib>Cha, Dongsu</creatorcontrib><title>Carboxymethyl chitosan and carboxymethyl cellulose based self-healing hydrogel for accelerating diabetic wound healing</title><title>Carbohydrate polymers</title><description>In this study, a new type of biodegradable, injectable, self-healing, and low-toxic CMCSH, formed by N, O-carboxymethyl chitosan-heparin (CMCS-Hep) and carboxymethyl cellulose-aldehyde (CMC-A), was designed to deliver drug for promoting the progress of the diabetic wound healing. 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CMCS was modified with Hep for the first time to synthesize CMCS-Hep, and CMC-A was synthesized by the periodate oxidation method. First, SOD encapsulated in the CMCSH was applied to the diabetic wound bed to moderate the microenvironment, then rhEGF retained in the CMCSH was sustainedly released to the wound area. These results indicated that the dual-drug delivery system had the ability to improve drug availability, promote cell migration and proliferation, reduce DNA damage, shorten the inflammatory period, and accelerate the deposition of collagen fibers and the formation of blood vessels in the model with diabetic skin injury, suggesting that CMCSH as drug carriers had positive effects on diabetic wound healing.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.carbpol.2022.119687</doi><tpages>1</tpages></addata></record> |
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| ispartof | Carbohydrate polymers, 2022-09, Vol.292, p.119687-119687, Article 119687 |
| issn | 0144-8617 1879-1344 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Carboxymethyl cellulose Carboxymethyl chitosan Control release Diabetic wound healing Heparin Self-healing hydrogel |
| title | Carboxymethyl chitosan and carboxymethyl cellulose based self-healing hydrogel for accelerating diabetic wound healing |
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