Caffeine excites medial parabrachial nucleus neurons of mice by blocking adenosine A1 receptor

•Caffeine excites MPB neurons of mice by blocking A1Rs.•Caffeine could increase the efficiency of synaptic transmission to excite the MPB neurons.•The A1Rs in MPB may be potential targets of caffeine to reduce apnea neonatorum. Caffeine has been used as a first-line drug for treatment of apnea neona...

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Veröffentlicht in:	Brain research 2022-09, Vol.1790, p.147984-147984, Article 147984
Hauptverfasser:	Shi, Hua, Tu, Yunjia, Li, Yuanai, Ma, Chunyan, Gyabaah, Adwoa Takyiwaa, Yu, Chenyi, Li, Zhijie, Chen, Jiayi, Li, Zhilin, Huang, Zhi-Li, Cai, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A1 receptors Apnea neonatorum Caffeine Medial Parabrachial Nucleus Patch-clamp Synaptic transmission
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