Recombinant l‐Amino Acid Oxidase with Broad Substrate Spectrum for Co‐substrate Recycling in (S)‐Selective Transaminase‐Catalyzed Kinetic Resolutions

Chiral and enantiopure amines can be produced by enantioselective transaminases via kinetic resolution of amine racemates. This transamination reaction requires stoichiometric amounts of co‐substrate. A dual‐enzyme recycling system overcomes this limitation: l‐amino acid oxidases (LAAO) recycle the...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2022-08, Vol.23 (16), p.e202200329-n/a
Hauptverfasser:	Heinks, Tobias, Paulus, Jannik, Koopmeiners, Simon, Beuel, Tobias, Sewald, Norbert, Höhne, Matthias, Bornscheuer, Uwe T., Fischer von Mollard, Gabriele
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Amino acid oxidase Amino acids biocatalysis Catalase co-substrate recycling Enantiomers enantiopure (R)-amines Hydrogen peroxide kinetic resolution l-amino acid oxidase (LAAO) Recycling Recycling systems Stoichiometry Substrates Transaminase Transaminases
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