Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?

Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?

The development of cardiovascular disease shows increase after contracting coronavirus 2019 (COVID‐19) disease and myocardial damage is observed in patients who have had the disease severely. The relationship between genetic cardiovascular risk factors with COVID‐19 infection was investigated in our...

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Veröffentlicht in:Journal of medical virology 2022-10, Vol.94 (10), p.4803-4808
Hauptverfasser: Ceylan, Mehmet Reşat, Kankılıç, Nazım, Öz, Özlem
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cardiovascular diseases
Coronaviruses
COVID-19
Fibrinogen
Genes
Genotypes
Haplotypes
Health risks
Infections
Patients
Platelets
PROCR H1
PROCR H3
Protein C
Proteins
Receptors
Risk analysis
Risk factors
sEPCR
Sequence analysis
Viral diseases
Virology
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container_title Journal of medical virology
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creator Ceylan, Mehmet Reşat
Kankılıç, Nazım
Öz, Özlem
description The development of cardiovascular disease shows increase after contracting coronavirus 2019 (COVID‐19) disease and myocardial damage is observed in patients who have had the disease severely. The relationship between genetic cardiovascular risk factors with COVID‐19 infection was investigated in our study. One hundred thirty‐five patients, 27 of whom were COVID‐19 (−) and 108 were COVID‐19 (+) patients, were included in the study. Patients were divided into three groups ([COVID‐19 [−], COVID‐19 [+] asymptomatic, and COVID‐19 [+] symptomatic + patients with pulmonary involvement]). Genetic cardiovascular risk factors were examined in blood samples taken from the patients with new generation sequencing analysis. In the clinical classification, there were no significant differences between the three groups in fibrinogen beta chain—455G>A, human platelet antigen 1 (HPA1b)/platelet receptor GPIIIa/(ITGB3) (HPA1a/b; GpIIIa; integrin beta 3 L33P), ACE I/D, AGT (M268T), AGTR1 (1166A>C), Apo E (E2/E3/E4) (rs7412, rs429358), eNOS (786T>C), eNOS (894G>T) genes (p > 0.05). However, significant differences were observed in PROCR H3 haplotype/G (endothelial protein C receptor gene [EPCR] 4600A>G [A3 haplotype]), PROCR H1 haplotype/C (EPCR 4678G>C [A1 haplotype]) genes (p 
doi_str_mv 10.1002/jmv.27938
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The relationship between genetic cardiovascular risk factors with COVID‐19 infection was investigated in our study. One hundred thirty‐five patients, 27 of whom were COVID‐19 (−) and 108 were COVID‐19 (+) patients, were included in the study. Patients were divided into three groups ([COVID‐19 [−], COVID‐19 [+] asymptomatic, and COVID‐19 [+] symptomatic + patients with pulmonary involvement]). Genetic cardiovascular risk factors were examined in blood samples taken from the patients with new generation sequencing analysis. In the clinical classification, there were no significant differences between the three groups in fibrinogen beta chain—455G&gt;A, human platelet antigen 1 (HPA1b)/platelet receptor GPIIIa/(ITGB3) (HPA1a/b; GpIIIa; integrin beta 3 L33P), ACE I/D, AGT (M268T), AGTR1 (1166A&gt;C), Apo E (E2/E3/E4) (rs7412, rs429358), eNOS (786T&gt;C), eNOS (894G&gt;T) genes (p &gt; 0.05). However, significant differences were observed in PROCR H3 haplotype/G (endothelial protein C receptor gene [EPCR] 4600A&gt;G [A3 haplotype]), PROCR H1 haplotype/C (EPCR 4678G&gt;C [A1 haplotype]) genes (p &lt; 0.05). When COVID‐19 (+) and COVID‐19 (−) groups were compared, it was observed that the infection was more common in people with PROCR H1 haplotype/C and PROCR H3 haplotype/G genotypes (p &lt; 0.05). PROCR H1 and PROCR H3 haplotypes may be an important factor in contracting COVID‐19 disease. In people with COVID‐19 disease, revealing PROCR genetic differences and measuring sEPCR levels will be beneficial in the follow‐up of the disease.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.27938</identifier><language>eng</language><publisher>London: Wiley Subscription Services, Inc</publisher><subject>Antigens ; Cardiovascular diseases ; Coronaviruses ; COVID-19 ; Fibrinogen ; Genes ; Genotypes ; Haplotypes ; Health risks ; Infections ; Patients ; Platelets ; PROCR H1 ; PROCR H3 ; Protein C ; Proteins ; Receptors ; Risk analysis ; Risk factors ; sEPCR ; Sequence analysis ; Viral diseases ; Virology</subject><ispartof>Journal of medical virology, 2022-10, Vol.94 (10), p.4803-4808</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2208-664e40c5f68cf5d761677e07def2d0247b999e259ca025c430d292bbd1052aeb3</cites><orcidid>0000-0001-8063-4836</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.27938$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.27938$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Ceylan, Mehmet Reşat</creatorcontrib><creatorcontrib>Kankılıç, Nazım</creatorcontrib><creatorcontrib>Öz, Özlem</creatorcontrib><title>Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?</title><title>Journal of medical virology</title><description>The development of cardiovascular disease shows increase after contracting coronavirus 2019 (COVID‐19) disease and myocardial damage is observed in patients who have had the disease severely. The relationship between genetic cardiovascular risk factors with COVID‐19 infection was investigated in our study. One hundred thirty‐five patients, 27 of whom were COVID‐19 (−) and 108 were COVID‐19 (+) patients, were included in the study. Patients were divided into three groups ([COVID‐19 [−], COVID‐19 [+] asymptomatic, and COVID‐19 [+] symptomatic + patients with pulmonary involvement]). Genetic cardiovascular risk factors were examined in blood samples taken from the patients with new generation sequencing analysis. In the clinical classification, there were no significant differences between the three groups in fibrinogen beta chain—455G&gt;A, human platelet antigen 1 (HPA1b)/platelet receptor GPIIIa/(ITGB3) (HPA1a/b; GpIIIa; integrin beta 3 L33P), ACE I/D, AGT (M268T), AGTR1 (1166A&gt;C), Apo E (E2/E3/E4) (rs7412, rs429358), eNOS (786T&gt;C), eNOS (894G&gt;T) genes (p &gt; 0.05). However, significant differences were observed in PROCR H3 haplotype/G (endothelial protein C receptor gene [EPCR] 4600A&gt;G [A3 haplotype]), PROCR H1 haplotype/C (EPCR 4678G&gt;C [A1 haplotype]) genes (p &lt; 0.05). When COVID‐19 (+) and COVID‐19 (−) groups were compared, it was observed that the infection was more common in people with PROCR H1 haplotype/C and PROCR H3 haplotype/G genotypes (p &lt; 0.05). PROCR H1 and PROCR H3 haplotypes may be an important factor in contracting COVID‐19 disease. In people with COVID‐19 disease, revealing PROCR genetic differences and measuring sEPCR levels will be beneficial in the follow‐up of the disease.</description><subject>Antigens</subject><subject>Cardiovascular diseases</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Fibrinogen</subject><subject>Genes</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Health risks</subject><subject>Infections</subject><subject>Patients</subject><subject>Platelets</subject><subject>PROCR H1</subject><subject>PROCR H3</subject><subject>Protein C</subject><subject>Proteins</subject><subject>Receptors</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>sEPCR</subject><subject>Sequence analysis</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10MFOGzEQBmCraqWmtAfewBIXOCSMJ7v2-lShhTZBQakQcLUc7yxstFkv9gaUWx-hz9gnqSGcKnGyRv5m9Otn7FDARADg6XrzNEGlp8UHNhKg5ViDEh_ZCEQmx1KK_DP7EuMaAAqNOGKPZ4H4THDbVXw25Q-2b_2w6ylyX3PqKj88UNvYlvfBD9R0vOSBHPWDD_z41_WyvD5Ju7zZ9D4Mtht4bd3LX5LOd0NIU9Pd83J5Nz__-_uP0N-_sk-1bSN9e3sP2O2Pi5tyNl4sf87Ls8XYIUKRsmaUgctrWbg6r5QUUikCVVGNFWCmVlprwlw7C5i7bAoValytKgE5WlpND9jx_m5K_rilOJhNEx21re3Ib6NBqYoMCy3zRI_-o2u_DV1KZ1ABKpWDhqRO9soFH2Og2vSh2diwMwLMS_kmlW9ey0_2dG-fm5Z270NzeXW33_gHnZqEfQ</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Ceylan, Mehmet Reşat</creator><creator>Kankılıç, Nazım</creator><creator>Öz, Özlem</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8063-4836</orcidid></search><sort><creationdate>202210</creationdate><title>Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?</title><author>Ceylan, Mehmet Reşat ; Kankılıç, Nazım ; Öz, Özlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2208-664e40c5f68cf5d761677e07def2d0247b999e259ca025c430d292bbd1052aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>Cardiovascular diseases</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Fibrinogen</topic><topic>Genes</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Health risks</topic><topic>Infections</topic><topic>Patients</topic><topic>Platelets</topic><topic>PROCR H1</topic><topic>PROCR H3</topic><topic>Protein C</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>sEPCR</topic><topic>Sequence analysis</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceylan, Mehmet Reşat</creatorcontrib><creatorcontrib>Kankılıç, Nazım</creatorcontrib><creatorcontrib>Öz, Özlem</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceylan, Mehmet Reşat</au><au>Kankılıç, Nazım</au><au>Öz, Özlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?</atitle><jtitle>Journal of medical virology</jtitle><date>2022-10</date><risdate>2022</risdate><volume>94</volume><issue>10</issue><spage>4803</spage><epage>4808</epage><pages>4803-4808</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>The development of cardiovascular disease shows increase after contracting coronavirus 2019 (COVID‐19) disease and myocardial damage is observed in patients who have had the disease severely. The relationship between genetic cardiovascular risk factors with COVID‐19 infection was investigated in our study. One hundred thirty‐five patients, 27 of whom were COVID‐19 (−) and 108 were COVID‐19 (+) patients, were included in the study. Patients were divided into three groups ([COVID‐19 [−], COVID‐19 [+] asymptomatic, and COVID‐19 [+] symptomatic + patients with pulmonary involvement]). Genetic cardiovascular risk factors were examined in blood samples taken from the patients with new generation sequencing analysis. In the clinical classification, there were no significant differences between the three groups in fibrinogen beta chain—455G&gt;A, human platelet antigen 1 (HPA1b)/platelet receptor GPIIIa/(ITGB3) (HPA1a/b; GpIIIa; integrin beta 3 L33P), ACE I/D, AGT (M268T), AGTR1 (1166A&gt;C), Apo E (E2/E3/E4) (rs7412, rs429358), eNOS (786T&gt;C), eNOS (894G&gt;T) genes (p &gt; 0.05). However, significant differences were observed in PROCR H3 haplotype/G (endothelial protein C receptor gene [EPCR] 4600A&gt;G [A3 haplotype]), PROCR H1 haplotype/C (EPCR 4678G&gt;C [A1 haplotype]) genes (p &lt; 0.05). When COVID‐19 (+) and COVID‐19 (−) groups were compared, it was observed that the infection was more common in people with PROCR H1 haplotype/C and PROCR H3 haplotype/G genotypes (p &lt; 0.05). PROCR H1 and PROCR H3 haplotypes may be an important factor in contracting COVID‐19 disease. In people with COVID‐19 disease, revealing PROCR genetic differences and measuring sEPCR levels will be beneficial in the follow‐up of the disease.</abstract><cop>London</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jmv.27938</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8063-4836</orcidid></addata></record>
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ispartof Journal of medical virology, 2022-10, Vol.94 (10), p.4803-4808
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subjects Antigens
Cardiovascular diseases
Coronaviruses
COVID-19
Fibrinogen
Genes
Genotypes
Haplotypes
Health risks
Infections
Patients
Platelets
PROCR H1
PROCR H3
Protein C
Proteins
Receptors
Risk analysis
Risk factors
sEPCR
Sequence analysis
Viral diseases
Virology
title Are H1 and H3 haplotypes of endothelial protein C receptor (PROCR) an important factor in contracting COVID‐19?
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