Mice lacking DCAF2 in placenta die at the gastrulation stage

UV-damaged DNA-binding protein 1 (DDB1) and cullin 4-associated factor 2 (DCAF2, also known as DTL or CDT2) is an evolutionarily highly conserved substrate recognition factor in the cullin 4 RING E3 ubiquitin ligase (CRL4) complex. This complex degrades multiple DNA replication and cell cycle-associ...

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Veröffentlicht in:	Cell and tissue research 2022-09, Vol.389 (3), p.559-572
Hauptverfasser:	Yang, Man, Liu, Mei, Wang, Zongting, Zhang, Cong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Caspase-3 Cell cycle Cre recombinase Cullin Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA replication DNA-binding protein Ectoderm Gastrulation Genomes Genomics Genotypes Human Genetics Ligases Molecular Medicine Protein binding Proteomics Regular Article Ubiquitin Ubiquitin-protein ligase
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