Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis
The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS. A systematic search of electronic databases, including Google Scholar, the Coc...
Gespeichert in:
| Veröffentlicht in: | Clinical therapeutics 2022-07, Vol.44 (7), p.971-981 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 981 |
|---|---|
| container_issue | 7 |
| container_start_page | 971 |
| container_title | Clinical therapeutics |
| container_volume | 44 |
| creator | Qilin, Liu Yanbin, Zhang Dayong, Du Yang, Liu Huaizhi, Lu Tao, Zhang Miao, Yang Yi, Xue Yuntian, Li |
| description | The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS.
A systematic search of electronic databases, including Google Scholar, the Cochrane Central Register of Controlled Trials, and PubMed, was conducted. These studies were all published in English, and the databases were searched from inception to July 2021. All articles were evaluated independently by 2 researchers on the basis of inclusion and exclusion criteria. In the research, data about the incidence of major adverse cardiovascular events in CAS patients undergoing statin therapy was included and divided into different subgroups. A random effects model was conducted to synthesize the data.
Five cohort studies were included in the analysis. These results indicated that statins failed to reduce the incidence of stroke in patients with CAS in general. However, subgroup analysis revealed that statins were more effective in improving outcomes for CAS patients without severe coronary stenosis compared with those with severe coronary stenosis.
Statins may have a potential benefit in patients with CAS who do not have coronary stenosis. To investigate these findings further, future prospective, randomized controlled research will be required. |
| doi_str_mv | 10.1016/j.clinthera.2022.05.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2678424729</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149291822001916</els_id><sourcerecordid>2709725655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c376t-4e1a8090b0710af8a44584f9d62e78ed78e76526a3b4206e0b4cdcb3213c161a3</originalsourceid><addsrcrecordid>eNqFkMFO3DAQhi1UJLbQZ6glLr0kjB3HTnqLVltAWgQSIHqq5XUmwqtsvLWdSrw9Ros49MJhNIf55tfMR8h3BiUDJi-2pR3dlJ4xmJID5yXUJYA6IgvWqLZgTPz-QhbARFvwljUn5GuMWwCo2povyJ_VMKBN1A_0Ppnkpkj9RJc50Vkz0ts5Wb_DSN1E7_IYpxTpk0vPdOmDn0x4oV1ImNv93sTdT9rRG0ym6CYzvkQXz8jxYMaI3977KXn8tXpYXhXr28vrZbcubKVkKgQy00ALG1AMzNAYIepGDG0vOaoG-1xK1lyaaiM4SISNsL3dVJxVlklmqlPy45C7D_7vjDHpnYsWx9FM6OeouVSN4ELxNqPn_6FbP4d8b6YUtIrXsq4zpQ6UDT7GgIPeB7fL_2oG-s273uoP7_rNu4ZaZ-95sztsYv73n8Ogo83eLPYuZNO69-7TjFdwio7c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2709725655</pqid></control><display><type>article</type><title>Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis</title><source>Elsevier ScienceDirect Journals</source><creator>Qilin, Liu ; Yanbin, Zhang ; Dayong, Du ; Yang, Liu ; Huaizhi, Lu ; Tao, Zhang ; Miao, Yang ; Yi, Xue ; Yuntian, Li</creator><creatorcontrib>Qilin, Liu ; Yanbin, Zhang ; Dayong, Du ; Yang, Liu ; Huaizhi, Lu ; Tao, Zhang ; Miao, Yang ; Yi, Xue ; Yuntian, Li</creatorcontrib><description>The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS.
A systematic search of electronic databases, including Google Scholar, the Cochrane Central Register of Controlled Trials, and PubMed, was conducted. These studies were all published in English, and the databases were searched from inception to July 2021. All articles were evaluated independently by 2 researchers on the basis of inclusion and exclusion criteria. In the research, data about the incidence of major adverse cardiovascular events in CAS patients undergoing statin therapy was included and divided into different subgroups. A random effects model was conducted to synthesize the data.
Five cohort studies were included in the analysis. These results indicated that statins failed to reduce the incidence of stroke in patients with CAS in general. However, subgroup analysis revealed that statins were more effective in improving outcomes for CAS patients without severe coronary stenosis compared with those with severe coronary stenosis.
Statins may have a potential benefit in patients with CAS who do not have coronary stenosis. To investigate these findings further, future prospective, randomized controlled research will be required.</description><identifier>ISSN: 0149-2918</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.clinthera.2022.05.007</identifier><language>eng</language><publisher>Bridgewater: Elsevier Inc</publisher><subject>Angina pectoris ; Bias ; Cardiovascular disease ; Clinical outcomes ; Clinical trials ; Cohort analysis ; Coronary artery ; coronary artery spasm ; Coronary vessels ; Diabetes ; Evaluation ; Heart attacks ; Meta-analysis ; Patients ; Search engines ; Statins ; Stenosis ; Subgroups ; Veins & arteries</subject><ispartof>Clinical therapeutics, 2022-07, Vol.44 (7), p.971-981</ispartof><rights>2022 Elsevier Inc.</rights><rights>2022. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-4e1a8090b0710af8a44584f9d62e78ed78e76526a3b4206e0b4cdcb3213c161a3</citedby><cites>FETCH-LOGICAL-c376t-4e1a8090b0710af8a44584f9d62e78ed78e76526a3b4206e0b4cdcb3213c161a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0149291822001916$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Qilin, Liu</creatorcontrib><creatorcontrib>Yanbin, Zhang</creatorcontrib><creatorcontrib>Dayong, Du</creatorcontrib><creatorcontrib>Yang, Liu</creatorcontrib><creatorcontrib>Huaizhi, Lu</creatorcontrib><creatorcontrib>Tao, Zhang</creatorcontrib><creatorcontrib>Miao, Yang</creatorcontrib><creatorcontrib>Yi, Xue</creatorcontrib><creatorcontrib>Yuntian, Li</creatorcontrib><title>Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis</title><title>Clinical therapeutics</title><description>The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS.
A systematic search of electronic databases, including Google Scholar, the Cochrane Central Register of Controlled Trials, and PubMed, was conducted. These studies were all published in English, and the databases were searched from inception to July 2021. All articles were evaluated independently by 2 researchers on the basis of inclusion and exclusion criteria. In the research, data about the incidence of major adverse cardiovascular events in CAS patients undergoing statin therapy was included and divided into different subgroups. A random effects model was conducted to synthesize the data.
Five cohort studies were included in the analysis. These results indicated that statins failed to reduce the incidence of stroke in patients with CAS in general. However, subgroup analysis revealed that statins were more effective in improving outcomes for CAS patients without severe coronary stenosis compared with those with severe coronary stenosis.
Statins may have a potential benefit in patients with CAS who do not have coronary stenosis. To investigate these findings further, future prospective, randomized controlled research will be required.</description><subject>Angina pectoris</subject><subject>Bias</subject><subject>Cardiovascular disease</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Coronary artery</subject><subject>coronary artery spasm</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Evaluation</subject><subject>Heart attacks</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Search engines</subject><subject>Statins</subject><subject>Stenosis</subject><subject>Subgroups</subject><subject>Veins & arteries</subject><issn>0149-2918</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkMFO3DAQhi1UJLbQZ6glLr0kjB3HTnqLVltAWgQSIHqq5XUmwqtsvLWdSrw9Ros49MJhNIf55tfMR8h3BiUDJi-2pR3dlJ4xmJID5yXUJYA6IgvWqLZgTPz-QhbARFvwljUn5GuMWwCo2povyJ_VMKBN1A_0Ppnkpkj9RJc50Vkz0ts5Wb_DSN1E7_IYpxTpk0vPdOmDn0x4oV1ImNv93sTdT9rRG0ym6CYzvkQXz8jxYMaI3977KXn8tXpYXhXr28vrZbcubKVkKgQy00ALG1AMzNAYIepGDG0vOaoG-1xK1lyaaiM4SISNsL3dVJxVlklmqlPy45C7D_7vjDHpnYsWx9FM6OeouVSN4ELxNqPn_6FbP4d8b6YUtIrXsq4zpQ6UDT7GgIPeB7fL_2oG-s273uoP7_rNu4ZaZ-95sztsYv73n8Ogo83eLPYuZNO69-7TjFdwio7c</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Qilin, Liu</creator><creator>Yanbin, Zhang</creator><creator>Dayong, Du</creator><creator>Yang, Liu</creator><creator>Huaizhi, Lu</creator><creator>Tao, Zhang</creator><creator>Miao, Yang</creator><creator>Yi, Xue</creator><creator>Yuntian, Li</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202207</creationdate><title>Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis</title><author>Qilin, Liu ; Yanbin, Zhang ; Dayong, Du ; Yang, Liu ; Huaizhi, Lu ; Tao, Zhang ; Miao, Yang ; Yi, Xue ; Yuntian, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-4e1a8090b0710af8a44584f9d62e78ed78e76526a3b4206e0b4cdcb3213c161a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angina pectoris</topic><topic>Bias</topic><topic>Cardiovascular disease</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Coronary artery</topic><topic>coronary artery spasm</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Evaluation</topic><topic>Heart attacks</topic><topic>Meta-analysis</topic><topic>Patients</topic><topic>Search engines</topic><topic>Statins</topic><topic>Stenosis</topic><topic>Subgroups</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qilin, Liu</creatorcontrib><creatorcontrib>Yanbin, Zhang</creatorcontrib><creatorcontrib>Dayong, Du</creatorcontrib><creatorcontrib>Yang, Liu</creatorcontrib><creatorcontrib>Huaizhi, Lu</creatorcontrib><creatorcontrib>Tao, Zhang</creatorcontrib><creatorcontrib>Miao, Yang</creatorcontrib><creatorcontrib>Yi, Xue</creatorcontrib><creatorcontrib>Yuntian, Li</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qilin, Liu</au><au>Yanbin, Zhang</au><au>Dayong, Du</au><au>Yang, Liu</au><au>Huaizhi, Lu</au><au>Tao, Zhang</au><au>Miao, Yang</au><au>Yi, Xue</au><au>Yuntian, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis</atitle><jtitle>Clinical therapeutics</jtitle><date>2022-07</date><risdate>2022</risdate><volume>44</volume><issue>7</issue><spage>971</spage><epage>981</epage><pages>971-981</pages><issn>0149-2918</issn><eissn>1879-114X</eissn><abstract>The purpose of this meta-analysis was to assess the effect of statins on major adverse cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate the effectiveness of statins in patients with CAS.
A systematic search of electronic databases, including Google Scholar, the Cochrane Central Register of Controlled Trials, and PubMed, was conducted. These studies were all published in English, and the databases were searched from inception to July 2021. All articles were evaluated independently by 2 researchers on the basis of inclusion and exclusion criteria. In the research, data about the incidence of major adverse cardiovascular events in CAS patients undergoing statin therapy was included and divided into different subgroups. A random effects model was conducted to synthesize the data.
Five cohort studies were included in the analysis. These results indicated that statins failed to reduce the incidence of stroke in patients with CAS in general. However, subgroup analysis revealed that statins were more effective in improving outcomes for CAS patients without severe coronary stenosis compared with those with severe coronary stenosis.
Statins may have a potential benefit in patients with CAS who do not have coronary stenosis. To investigate these findings further, future prospective, randomized controlled research will be required.</abstract><cop>Bridgewater</cop><pub>Elsevier Inc</pub><doi>10.1016/j.clinthera.2022.05.007</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-2918 |
| ispartof | Clinical therapeutics, 2022-07, Vol.44 (7), p.971-981 |
| issn | 0149-2918 1879-114X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2678424729 |
| source | Elsevier ScienceDirect Journals |
| subjects | Angina pectoris Bias Cardiovascular disease Clinical outcomes Clinical trials Cohort analysis Coronary artery coronary artery spasm Coronary vessels Diabetes Evaluation Heart attacks Meta-analysis Patients Search engines Statins Stenosis Subgroups Veins & arteries |
| title | Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T22%3A10%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Statins%20on%20Clinical%20Outcomes%20in%20Patients%20With%20Coronary%20Artery%20Spasm:%20A%20Meta-Analysis&rft.jtitle=Clinical%20therapeutics&rft.au=Qilin,%20Liu&rft.date=2022-07&rft.volume=44&rft.issue=7&rft.spage=971&rft.epage=981&rft.pages=971-981&rft.issn=0149-2918&rft.eissn=1879-114X&rft_id=info:doi/10.1016/j.clinthera.2022.05.007&rft_dat=%3Cproquest_cross%3E2709725655%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2709725655&rft_id=info:pmid/&rft_els_id=S0149291822001916&rfr_iscdi=true |