Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?
Introduction Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utiliz...
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| Veröffentlicht in: | Clinical transplantation 2022-09, Vol.36 (9), p.e14751-n/a |
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| creator | Okumura, Kenji Misawa, Ryosuke Ohira, Suguru Dhand, Abhay Kai, Masashi Sogawa, Hiroshi Veillette, Gregory John, Devon Diflo, Thomas Nishida, Seigo |
| description | Introduction
Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor.
Methods
We analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January‐2020 to September‐2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short‐term outcomes of liver and kidney transplants between two groups.
Results
Total of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1‐year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062).
Conclusion
Utilization of heart machine perfusion in DCD donors had no significant impact on 1‐year outcomes of liver and kidney transplantation. |
| doi_str_mv | 10.1111/ctr.14751 |
| format | Article |
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Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor.
Methods
We analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January‐2020 to September‐2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short‐term outcomes of liver and kidney transplants between two groups.
Results
Total of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1‐year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062).
Conclusion
Utilization of heart machine perfusion in DCD donors had no significant impact on 1‐year outcomes of liver and kidney transplantation.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.14751</identifier><identifier>PMID: 35706100</identifier><language>eng</language><publisher>Denmark</publisher><subject>donation after cardiac death ; heart machine perfusion ; kidney transplant ; liver transplant</subject><ispartof>Clinical transplantation, 2022-09, Vol.36 (9), p.e14751-n/a</ispartof><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3251-3dbfe86dedcb89592a148dee29c52d7eb9e539e72b35e3f992a06edfc09d32be3</citedby><cites>FETCH-LOGICAL-c3251-3dbfe86dedcb89592a148dee29c52d7eb9e539e72b35e3f992a06edfc09d32be3</cites><orcidid>0000-0003-3527-1938 ; 0000-0002-4059-2309 ; 0000-0002-2192-4929 ; 0000-0002-1504-3551 ; 0000-0002-7751-2624 ; 0000-0003-0247-865X ; 0000-0001-8635-0578 ; 0000-0002-7108-6062 ; 0000-0003-0605-095X ; 0000-0003-3724-9005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.14751$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.14751$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35706100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okumura, Kenji</creatorcontrib><creatorcontrib>Misawa, Ryosuke</creatorcontrib><creatorcontrib>Ohira, Suguru</creatorcontrib><creatorcontrib>Dhand, Abhay</creatorcontrib><creatorcontrib>Kai, Masashi</creatorcontrib><creatorcontrib>Sogawa, Hiroshi</creatorcontrib><creatorcontrib>Veillette, Gregory</creatorcontrib><creatorcontrib>John, Devon</creatorcontrib><creatorcontrib>Diflo, Thomas</creatorcontrib><creatorcontrib>Nishida, Seigo</creatorcontrib><title>Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Introduction
Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor.
Methods
We analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January‐2020 to September‐2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short‐term outcomes of liver and kidney transplants between two groups.
Results
Total of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1‐year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062).
Conclusion
Utilization of heart machine perfusion in DCD donors had no significant impact on 1‐year outcomes of liver and kidney transplantation.</description><subject>donation after cardiac death</subject><subject>heart machine perfusion</subject><subject>kidney transplant</subject><subject>liver transplant</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kctOAyEUhonRaL0sfAHDUhe1XMpMWRlTr4mJianrCQMHi5kZKjAx9Tl8YNFR40Y2cOA7H4QfoUNKTmkeE53CKZ2Wgm6gEeVSjgmhbBONiCQsrwu-g3ZjfM67BS3ENtrhoiQFJWSE3i88RNwn17g3lZzvsLd4CSok3Cq9dB3gFQTbx88j6wM2vhs4ZRMErFUwTmlsQKUlTkF1cdWoLv0wFnTCvk_at_me7PZpmdtUbXzrOtX8aQGDfXjK1dk-2rKqiXDwPe-hx6vLxfxmfHd_fTs_vxtrzgQdc1NbmBUGjK5nUkim6HRmAJjUgpkSagmCSyhZzQVwKzNACjBWE2k4q4HvoePBuwr-pYeYqtZFDU1-Dfg-VqwoS1FOp6zI6MmA6uBjDGCrVXCtCuuKkuozhCqHUH2FkNmjb21ft2B-yZ9fz8BkAF5dA-v_TdV88TAoPwDPzJW2</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Okumura, Kenji</creator><creator>Misawa, Ryosuke</creator><creator>Ohira, Suguru</creator><creator>Dhand, Abhay</creator><creator>Kai, Masashi</creator><creator>Sogawa, Hiroshi</creator><creator>Veillette, Gregory</creator><creator>John, Devon</creator><creator>Diflo, Thomas</creator><creator>Nishida, Seigo</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3527-1938</orcidid><orcidid>https://orcid.org/0000-0002-4059-2309</orcidid><orcidid>https://orcid.org/0000-0002-2192-4929</orcidid><orcidid>https://orcid.org/0000-0002-1504-3551</orcidid><orcidid>https://orcid.org/0000-0002-7751-2624</orcidid><orcidid>https://orcid.org/0000-0003-0247-865X</orcidid><orcidid>https://orcid.org/0000-0001-8635-0578</orcidid><orcidid>https://orcid.org/0000-0002-7108-6062</orcidid><orcidid>https://orcid.org/0000-0003-0605-095X</orcidid><orcidid>https://orcid.org/0000-0003-3724-9005</orcidid></search><sort><creationdate>202209</creationdate><title>Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?</title><author>Okumura, Kenji ; Misawa, Ryosuke ; Ohira, Suguru ; Dhand, Abhay ; Kai, Masashi ; Sogawa, Hiroshi ; Veillette, Gregory ; John, Devon ; Diflo, Thomas ; Nishida, Seigo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3251-3dbfe86dedcb89592a148dee29c52d7eb9e539e72b35e3f992a06edfc09d32be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>donation after cardiac death</topic><topic>heart machine perfusion</topic><topic>kidney transplant</topic><topic>liver transplant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okumura, Kenji</creatorcontrib><creatorcontrib>Misawa, Ryosuke</creatorcontrib><creatorcontrib>Ohira, Suguru</creatorcontrib><creatorcontrib>Dhand, Abhay</creatorcontrib><creatorcontrib>Kai, Masashi</creatorcontrib><creatorcontrib>Sogawa, Hiroshi</creatorcontrib><creatorcontrib>Veillette, Gregory</creatorcontrib><creatorcontrib>John, Devon</creatorcontrib><creatorcontrib>Diflo, Thomas</creatorcontrib><creatorcontrib>Nishida, Seigo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okumura, Kenji</au><au>Misawa, Ryosuke</au><au>Ohira, Suguru</au><au>Dhand, Abhay</au><au>Kai, Masashi</au><au>Sogawa, Hiroshi</au><au>Veillette, Gregory</au><au>John, Devon</au><au>Diflo, Thomas</au><au>Nishida, Seigo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2022-09</date><risdate>2022</risdate><volume>36</volume><issue>9</issue><spage>e14751</spage><epage>n/a</epage><pages>e14751-n/a</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>Introduction
Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor.
Methods
We analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January‐2020 to September‐2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short‐term outcomes of liver and kidney transplants between two groups.
Results
Total of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1‐year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062).
Conclusion
Utilization of heart machine perfusion in DCD donors had no significant impact on 1‐year outcomes of liver and kidney transplantation.</abstract><cop>Denmark</cop><pmid>35706100</pmid><doi>10.1111/ctr.14751</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3527-1938</orcidid><orcidid>https://orcid.org/0000-0002-4059-2309</orcidid><orcidid>https://orcid.org/0000-0002-2192-4929</orcidid><orcidid>https://orcid.org/0000-0002-1504-3551</orcidid><orcidid>https://orcid.org/0000-0002-7751-2624</orcidid><orcidid>https://orcid.org/0000-0003-0247-865X</orcidid><orcidid>https://orcid.org/0000-0001-8635-0578</orcidid><orcidid>https://orcid.org/0000-0002-7108-6062</orcidid><orcidid>https://orcid.org/0000-0003-0605-095X</orcidid><orcidid>https://orcid.org/0000-0003-3724-9005</orcidid></addata></record> |
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| ispartof | Clinical transplantation, 2022-09, Vol.36 (9), p.e14751-n/a |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | donation after cardiac death heart machine perfusion kidney transplant liver transplant |
| title | Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs? |
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