Immunopotentiation by linking Hsp70 T-cell epitopes to Gag-Pol-Env-Nef-Rev multiepitope construct and increased IFN-gamma secretion in infected lymphocytes

Abstract Therapeutic human immunodeficiency virus (HIV) vaccines can boost the anti-HIV host immunity to control viral replication and eliminate viral reservoirs in the absence of anti-retroviral therapy. In this study, two computationally designed multiepitope Gag-Pol-Env-Nef-Rev and Hsp70-Gag-Pol-...

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Veröffentlicht in:	Pathogens and disease 2022-07, Vol.80 (1)
Hauptverfasser:	Akbari, Elahe, Ajdary, Soheila, Mirabzadeh Ardakani, Esmat, Agi, Elnaz, Milani, Alireza, Seyedinkhorasani, Masoud, Khalaj, Vahid, Bolhassani, Azam
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Cytokines DNA vaccines E coli Epitopes Gag protein Granzyme B Heat shock proteins HIV Homology Hsp70 protein Human immunodeficiency virus Immunogenicity Immunoglobulin G Interleukin 10 Interleukin 5 Lymphocytes Lymphocytes T Nef protein Polypeptides Splenocytes Vaccines Virions γ-Interferon
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