Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study
Purpose To compare iris affectation in cytomegalovirus anterior uveitis (CMVAU), rubella virus-associated uveitis (RVU), and healthy contralateral eyes, using swept-source anterior segment optical coherence tomography (SS-AS-OCT). Materials and methods A comparative, transversal, retrospective study...
Gespeichert in:
| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2022-11, Vol.260 (11), p.3647-3655 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3655 |
|---|---|
| container_issue | 11 |
| container_start_page | 3647 |
| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 260 |
| creator | Escribano Lopez, Patricia Gonzalez Guijarro, Juan Jacobo |
| description | Purpose
To compare iris affectation in cytomegalovirus anterior uveitis (CMVAU), rubella virus-associated uveitis (RVU), and healthy contralateral eyes, using swept-source anterior segment optical coherence tomography (SS-AS-OCT).
Materials and methods
A comparative, transversal, retrospective study examining 60 eyes from 30 patients—18 eyes (17 patients) with CMVAU, 14 eyes (13 patients) with RVU, and 28 healthy eyes—was performed. Six-millimeter cross-sectional SS-AS-OCT B-scans were obtained in each iris quadrant. Images were exported to ImageJ®. Qualitative and quantitative analyses were done: stromal thickness (ST), smooth index (SI), and optical density (OD) of pigment epithelium. Comparisons between measurements and clinical-demographic parameters were performed using SPSS®.
Results
Qualitative analysis showed extensive damage in iris stroma but was unable to differentiate between both uveitis. RVU eyes had a lower mean ST (315.72 μm ± 42.4) compared to those with CMVAU (348.6 μm ± 46) (
p
= 0.047) and a lower ST in the upper (338.9 μm ± 38.52)/(386.25 μm ± 47.2) (
p
= 0.005) and temporal (281.5 μm ± 57.3)/(326.43 μm ± 62.3) (
p
= 0.016) quadrants. Mean (0.94 ± 0.02)/(0.9 ± 0.03) (
p
= 0.001), temporal (0.94 ± 0.02)/(0.89 ± 0.03) (
p
|
| doi_str_mv | 10.1007/s00417-022-05733-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2677573472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2677573472</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-db710906e5779c3518918e7a91d4c1a8c4f084b5b4c37419ace04d683d86202d3</originalsourceid><addsrcrecordid>eNp9kUtLAzEYRYMoWqt_wIUE3LgZ_fKaZNxJ8QWCmwruQiZJS6QzU5OZQv-9qa0KLlwlkHNvvuQgdEbgigDI6wTAiSyA0gKEZKxge2hEOBOFBPq2j0YgKSkUo29H6Dild8g8E-QQHTEhQSkuRyg-xeCCabFpex9DF3Hy88a3PX6ZTHFocRxqv1gYPKx86EPCad262DU-Bxy26z5v52bRrUIc0m_Jjr7BBtuuWZpo-rDyOPWDW5-gg5lZJH-6W8fo9f5uOnksnl8enia3z4WlouwLV0sCFZReSFnZPLeqiPLSVMRxS4yyfAaK16LmlklOKmM9cFcq5lRJgTo2Rpfb3mXsPgafet2EZDePaX03JE1LKfO3cUkzevEHfe-G2ObpNJW0JEJUimWKbikbu5Sin-llDI2Ja01Ab4zorRGdjegvI3oTOt9VD3Xj3U_kW0EG2BZI-aid-_h79z-1n8irl0k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2726155983</pqid></control><display><type>article</type><title>Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study</title><source>Springer Nature - Complete Springer Journals</source><creator>Escribano Lopez, Patricia ; Gonzalez Guijarro, Juan Jacobo</creator><creatorcontrib>Escribano Lopez, Patricia ; Gonzalez Guijarro, Juan Jacobo</creatorcontrib><description>Purpose
To compare iris affectation in cytomegalovirus anterior uveitis (CMVAU), rubella virus-associated uveitis (RVU), and healthy contralateral eyes, using swept-source anterior segment optical coherence tomography (SS-AS-OCT).
Materials and methods
A comparative, transversal, retrospective study examining 60 eyes from 30 patients—18 eyes (17 patients) with CMVAU, 14 eyes (13 patients) with RVU, and 28 healthy eyes—was performed. Six-millimeter cross-sectional SS-AS-OCT B-scans were obtained in each iris quadrant. Images were exported to ImageJ®. Qualitative and quantitative analyses were done: stromal thickness (ST), smooth index (SI), and optical density (OD) of pigment epithelium. Comparisons between measurements and clinical-demographic parameters were performed using SPSS®.
Results
Qualitative analysis showed extensive damage in iris stroma but was unable to differentiate between both uveitis. RVU eyes had a lower mean ST (315.72 μm ± 42.4) compared to those with CMVAU (348.6 μm ± 46) (
p
= 0.047) and a lower ST in the upper (338.9 μm ± 38.52)/(386.25 μm ± 47.2) (
p
= 0.005) and temporal (281.5 μm ± 57.3)/(326.43 μm ± 62.3) (
p
= 0.016) quadrants. Mean (0.94 ± 0.02)/(0.9 ± 0.03) (
p
= 0.001), temporal (0.94 ± 0.02)/(0.89 ± 0.03) (
p
< 0.001), and nasal SI (0.094 ± 0.02)/(0.9 ± 0.04) (
p
= 0.005) were higher in RVU. OD was similar in both uveitis. In healthy eyes, mean ST (376.8 μm ± 39.7) was higher and mean SI was lower (0.87 ± 0.04) than in RVU (
p
< 0.001) and CMVAU eyes (
p
= 0.032). Mean OD was higher in healthy eyes (911 ± 130) than in CMVAU eyes (800 ± 200) (
p
= 0.037).
Conclusions
The quantitative analysis of the SS-AS-OCT iris images allows for the differentiation between healthy eyes and those with CMVAU and RVU, as well as between both uveitis.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-022-05733-3</identifier><identifier>PMID: 35708847</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cytomegalovirus ; Epithelium ; Inflammatory Disorders ; Iris ; Medicine ; Medicine & Public Health ; Ophthalmology ; Optical density ; Patients ; Rubella ; Stroma ; Uveitis</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2022-11, Vol.260 (11), p.3647-3655</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-db710906e5779c3518918e7a91d4c1a8c4f084b5b4c37419ace04d683d86202d3</cites><orcidid>0000-0002-7705-8759 ; 0000-0001-6379-7609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-022-05733-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-022-05733-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35708847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escribano Lopez, Patricia</creatorcontrib><creatorcontrib>Gonzalez Guijarro, Juan Jacobo</creatorcontrib><title>Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To compare iris affectation in cytomegalovirus anterior uveitis (CMVAU), rubella virus-associated uveitis (RVU), and healthy contralateral eyes, using swept-source anterior segment optical coherence tomography (SS-AS-OCT).
Materials and methods
A comparative, transversal, retrospective study examining 60 eyes from 30 patients—18 eyes (17 patients) with CMVAU, 14 eyes (13 patients) with RVU, and 28 healthy eyes—was performed. Six-millimeter cross-sectional SS-AS-OCT B-scans were obtained in each iris quadrant. Images were exported to ImageJ®. Qualitative and quantitative analyses were done: stromal thickness (ST), smooth index (SI), and optical density (OD) of pigment epithelium. Comparisons between measurements and clinical-demographic parameters were performed using SPSS®.
Results
Qualitative analysis showed extensive damage in iris stroma but was unable to differentiate between both uveitis. RVU eyes had a lower mean ST (315.72 μm ± 42.4) compared to those with CMVAU (348.6 μm ± 46) (
p
= 0.047) and a lower ST in the upper (338.9 μm ± 38.52)/(386.25 μm ± 47.2) (
p
= 0.005) and temporal (281.5 μm ± 57.3)/(326.43 μm ± 62.3) (
p
= 0.016) quadrants. Mean (0.94 ± 0.02)/(0.9 ± 0.03) (
p
= 0.001), temporal (0.94 ± 0.02)/(0.89 ± 0.03) (
p
< 0.001), and nasal SI (0.094 ± 0.02)/(0.9 ± 0.04) (
p
= 0.005) were higher in RVU. OD was similar in both uveitis. In healthy eyes, mean ST (376.8 μm ± 39.7) was higher and mean SI was lower (0.87 ± 0.04) than in RVU (
p
< 0.001) and CMVAU eyes (
p
= 0.032). Mean OD was higher in healthy eyes (911 ± 130) than in CMVAU eyes (800 ± 200) (
p
= 0.037).
Conclusions
The quantitative analysis of the SS-AS-OCT iris images allows for the differentiation between healthy eyes and those with CMVAU and RVU, as well as between both uveitis.</description><subject>Cytomegalovirus</subject><subject>Epithelium</subject><subject>Inflammatory Disorders</subject><subject>Iris</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Optical density</subject><subject>Patients</subject><subject>Rubella</subject><subject>Stroma</subject><subject>Uveitis</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLAzEYRYMoWqt_wIUE3LgZ_fKaZNxJ8QWCmwruQiZJS6QzU5OZQv-9qa0KLlwlkHNvvuQgdEbgigDI6wTAiSyA0gKEZKxge2hEOBOFBPq2j0YgKSkUo29H6Dild8g8E-QQHTEhQSkuRyg-xeCCabFpex9DF3Hy88a3PX6ZTHFocRxqv1gYPKx86EPCad262DU-Bxy26z5v52bRrUIc0m_Jjr7BBtuuWZpo-rDyOPWDW5-gg5lZJH-6W8fo9f5uOnksnl8enia3z4WlouwLV0sCFZReSFnZPLeqiPLSVMRxS4yyfAaK16LmlklOKmM9cFcq5lRJgTo2Rpfb3mXsPgafet2EZDePaX03JE1LKfO3cUkzevEHfe-G2ObpNJW0JEJUimWKbikbu5Sin-llDI2Ja01Ab4zorRGdjegvI3oTOt9VD3Xj3U_kW0EG2BZI-aid-_h79z-1n8irl0k</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Escribano Lopez, Patricia</creator><creator>Gonzalez Guijarro, Juan Jacobo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7705-8759</orcidid><orcidid>https://orcid.org/0000-0001-6379-7609</orcidid></search><sort><creationdate>20221101</creationdate><title>Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study</title><author>Escribano Lopez, Patricia ; Gonzalez Guijarro, Juan Jacobo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-db710906e5779c3518918e7a91d4c1a8c4f084b5b4c37419ace04d683d86202d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cytomegalovirus</topic><topic>Epithelium</topic><topic>Inflammatory Disorders</topic><topic>Iris</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Optical density</topic><topic>Patients</topic><topic>Rubella</topic><topic>Stroma</topic><topic>Uveitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escribano Lopez, Patricia</creatorcontrib><creatorcontrib>Gonzalez Guijarro, Juan Jacobo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escribano Lopez, Patricia</au><au>Gonzalez Guijarro, Juan Jacobo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>260</volume><issue>11</issue><spage>3647</spage><epage>3655</epage><pages>3647-3655</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To compare iris affectation in cytomegalovirus anterior uveitis (CMVAU), rubella virus-associated uveitis (RVU), and healthy contralateral eyes, using swept-source anterior segment optical coherence tomography (SS-AS-OCT).
Materials and methods
A comparative, transversal, retrospective study examining 60 eyes from 30 patients—18 eyes (17 patients) with CMVAU, 14 eyes (13 patients) with RVU, and 28 healthy eyes—was performed. Six-millimeter cross-sectional SS-AS-OCT B-scans were obtained in each iris quadrant. Images were exported to ImageJ®. Qualitative and quantitative analyses were done: stromal thickness (ST), smooth index (SI), and optical density (OD) of pigment epithelium. Comparisons between measurements and clinical-demographic parameters were performed using SPSS®.
Results
Qualitative analysis showed extensive damage in iris stroma but was unable to differentiate between both uveitis. RVU eyes had a lower mean ST (315.72 μm ± 42.4) compared to those with CMVAU (348.6 μm ± 46) (
p
= 0.047) and a lower ST in the upper (338.9 μm ± 38.52)/(386.25 μm ± 47.2) (
p
= 0.005) and temporal (281.5 μm ± 57.3)/(326.43 μm ± 62.3) (
p
= 0.016) quadrants. Mean (0.94 ± 0.02)/(0.9 ± 0.03) (
p
= 0.001), temporal (0.94 ± 0.02)/(0.89 ± 0.03) (
p
< 0.001), and nasal SI (0.094 ± 0.02)/(0.9 ± 0.04) (
p
= 0.005) were higher in RVU. OD was similar in both uveitis. In healthy eyes, mean ST (376.8 μm ± 39.7) was higher and mean SI was lower (0.87 ± 0.04) than in RVU (
p
< 0.001) and CMVAU eyes (
p
= 0.032). Mean OD was higher in healthy eyes (911 ± 130) than in CMVAU eyes (800 ± 200) (
p
= 0.037).
Conclusions
The quantitative analysis of the SS-AS-OCT iris images allows for the differentiation between healthy eyes and those with CMVAU and RVU, as well as between both uveitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35708847</pmid><doi>10.1007/s00417-022-05733-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7705-8759</orcidid><orcidid>https://orcid.org/0000-0001-6379-7609</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2022-11, Vol.260 (11), p.3647-3655 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2677573472 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cytomegalovirus Epithelium Inflammatory Disorders Iris Medicine Medicine & Public Health Ophthalmology Optical density Patients Rubella Stroma Uveitis |
| title | Iridian anterior segment OCT in rubella uveitis syndrome and cytomegalovirus anterior uveitis: a comparative study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T16%3A53%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Iridian%20anterior%20segment%20OCT%20in%20rubella%20uveitis%20syndrome%20and%20cytomegalovirus%20anterior%20uveitis:%20a%20comparative%20study&rft.jtitle=Graefe's%20archive%20for%20clinical%20and%20experimental%20ophthalmology&rft.au=Escribano%20Lopez,%20Patricia&rft.date=2022-11-01&rft.volume=260&rft.issue=11&rft.spage=3647&rft.epage=3655&rft.pages=3647-3655&rft.issn=0721-832X&rft.eissn=1435-702X&rft_id=info:doi/10.1007/s00417-022-05733-3&rft_dat=%3Cproquest_cross%3E2677573472%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2726155983&rft_id=info:pmid/35708847&rfr_iscdi=true |