Lifelong multilineage contribution by embryonic-born blood progenitors

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT) 1 – 4 . This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought...

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Veröffentlicht in:	Nature (London) 2022-06, Vol.606 (7915), p.747-753
Hauptverfasser:	Patel, Sachin H., Christodoulou, Constantina, Weinreb, Caleb, Yu, Qi, da Rocha, Edroaldo Lummertz, Pepe-Mooney, Brian J., Bowling, Sarah, Li, Li, Osorio, Fernando G., Daley, George Q., Camargo, Fernando D.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 38 38/91 631/136/232 631/136/532/1542 631/532/1542 64 64/60 Artificial chromosomes Blood Bone marrow Cell fate Cloning Embryos Endothelium Fate maps Granulocytes Hematopoietic stem cells Hemopoiesis Heterogeneity Humanities and Social Sciences Kinases Labeling Liver multidisciplinary Progenitor cells Science Science (multidisciplinary) Stem cell transplantation Stem cells Young adults
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