Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester
Due to the destruction of the integrity of the parent crystal, single‐crystal‐to‐single‐crystal phase transition in organic compounds is still a relatively rare phenomenon. The phase transition in glycyrrhetinic acid isopropyl ester is triggered by temperature change. The increasing volume of the is...
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| Veröffentlicht in: | Acta crystallographica Section B, Structural science, crystal engineering and materials Structural science, crystal engineering and materials, 2022-06, Vol.78 (3-2), p.450-458 |
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| container_title | Acta crystallographica Section B, Structural science, crystal engineering and materials |
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| creator | Langer, Dominik Wicher, Barbara Tykarska, Ewa |
| description | Due to the destruction of the integrity of the parent crystal, single‐crystal‐to‐single‐crystal phase transition in organic compounds is still a relatively rare phenomenon. The phase transition in glycyrrhetinic acid isopropyl ester is triggered by temperature change. The increasing volume of the isopropyl substituent as a result of increasing temperature forces a remodelling of the structural motifs. These changes cause a single‐crystal‐to‐single‐crystal phase transition. The low‐temperature form is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with the ethyl ester of this acid.
The single‐crystal‐to‐single‐crystal phase transition observed for glycyrrhetinic acid isopropyl ester is triggered by temperature change and causes the rebuilding of the structural motifs. The low‐temperature phase is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with glycyrrhetinic acid ethyl ester. |
| doi_str_mv | 10.1107/S2052520622002517 |
| format | Article |
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The single‐crystal‐to‐single‐crystal phase transition observed for glycyrrhetinic acid isopropyl ester is triggered by temperature change and causes the rebuilding of the structural motifs. The low‐temperature phase is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with glycyrrhetinic acid ethyl ester.</description><identifier>ISSN: 2052-5206</identifier><identifier>ISSN: 2052-5192</identifier><identifier>EISSN: 2052-5206</identifier><identifier>DOI: 10.1107/S2052520622002517</identifier><identifier>PMID: 35702962</identifier><language>eng</language><publisher>5 Abbey Square, Chester, Cheshire CH1 2HU, England: International Union of Crystallography</publisher><subject>Crystal structure ; differential scanning calorimetry ; DSC ; Ethyl esters ; glycyrrhetinic acid ; Organic compounds ; phase transition ; Phase transitions ; triterpene</subject><ispartof>Acta crystallographica Section B, Structural science, crystal engineering and materials, 2022-06, Vol.78 (3-2), p.450-458</ispartof><rights>2022 Dominik Langer et al. published by IUCr Journals.</rights><rights>Copyright Blackwell Publishing Ltd. Jun 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4228-17c9ea0828d127781576f6b57136694bc258e2f326265735de9f7646e12b4d53</citedby><cites>FETCH-LOGICAL-c4228-17c9ea0828d127781576f6b57136694bc258e2f326265735de9f7646e12b4d53</cites><orcidid>0000-0001-8659-8119 ; 0000-0003-2254-2508 ; 0000-0001-9393-3536</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1107%2FS2052520622002517$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1107%2FS2052520622002517$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35702962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Langer, Dominik</creatorcontrib><creatorcontrib>Wicher, Barbara</creatorcontrib><creatorcontrib>Tykarska, Ewa</creatorcontrib><title>Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester</title><title>Acta crystallographica Section B, Structural science, crystal engineering and materials</title><addtitle>Acta Crystallogr B Struct Sci Cryst Eng Mater</addtitle><description>Due to the destruction of the integrity of the parent crystal, single‐crystal‐to‐single‐crystal phase transition in organic compounds is still a relatively rare phenomenon. The phase transition in glycyrrhetinic acid isopropyl ester is triggered by temperature change. The increasing volume of the isopropyl substituent as a result of increasing temperature forces a remodelling of the structural motifs. These changes cause a single‐crystal‐to‐single‐crystal phase transition. The low‐temperature form is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with the ethyl ester of this acid.
The single‐crystal‐to‐single‐crystal phase transition observed for glycyrrhetinic acid isopropyl ester is triggered by temperature change and causes the rebuilding of the structural motifs. The low‐temperature phase is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with glycyrrhetinic acid ethyl ester.</description><subject>Crystal structure</subject><subject>differential scanning calorimetry</subject><subject>DSC</subject><subject>Ethyl esters</subject><subject>glycyrrhetinic acid</subject><subject>Organic compounds</subject><subject>phase transition</subject><subject>Phase transitions</subject><subject>triterpene</subject><issn>2052-5206</issn><issn>2052-5192</issn><issn>2052-5206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkU1OwzAQhS0EolXpAdigSGzYBOxJbCfLUvEnFSHRblhFieO0rtyk2IlQdhyBs3AQDsFJcNSCUFmwmRk9fe-N5UHomOBzQjC_mAKmQAEzAIyBEr6H-p3kd9r-r7mHhtYuMcbORoGRQ9QLKMcQM-ij-VSVcy0_X9-EaW2dajfVlSt2R_fWi9RKrzZpaVWtqtKrCo9EH-8OmetWtMYsZK1KJbxUqNxTtlqbat1qT9pamiN0UKTayuG2D9Ds-mo2vvUnDzd349HEFyFA5BMuYpniCKKcAOcRoZwVLKOcBIzFYSaARhKKABgwygOay7jgLGSSQBbmNBigs02s2_3cuM3JSlkhtU5LWTU2AcZZDEHAOvR0B11WjSnd4zoqYpSSmDiKbChhKmuNLJK1UavUtAnBSXeH5M8dnOdkm9xkK5n_OL5_3QHxBnhRWrb_Jyajp0t4vKeYRsEXQYGXPw</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Langer, Dominik</creator><creator>Wicher, Barbara</creator><creator>Tykarska, Ewa</creator><general>International Union of Crystallography</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8659-8119</orcidid><orcidid>https://orcid.org/0000-0003-2254-2508</orcidid><orcidid>https://orcid.org/0000-0001-9393-3536</orcidid></search><sort><creationdate>202206</creationdate><title>Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester</title><author>Langer, Dominik ; Wicher, Barbara ; Tykarska, Ewa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4228-17c9ea0828d127781576f6b57136694bc258e2f326265735de9f7646e12b4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Crystal structure</topic><topic>differential scanning calorimetry</topic><topic>DSC</topic><topic>Ethyl esters</topic><topic>glycyrrhetinic acid</topic><topic>Organic compounds</topic><topic>phase transition</topic><topic>Phase transitions</topic><topic>triterpene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langer, Dominik</creatorcontrib><creatorcontrib>Wicher, Barbara</creatorcontrib><creatorcontrib>Tykarska, Ewa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Acta crystallographica Section B, Structural science, crystal engineering and materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langer, Dominik</au><au>Wicher, Barbara</au><au>Tykarska, Ewa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester</atitle><jtitle>Acta crystallographica Section B, Structural science, crystal engineering and materials</jtitle><addtitle>Acta Crystallogr B Struct Sci Cryst Eng Mater</addtitle><date>2022-06</date><risdate>2022</risdate><volume>78</volume><issue>3-2</issue><spage>450</spage><epage>458</epage><pages>450-458</pages><issn>2052-5206</issn><issn>2052-5192</issn><eissn>2052-5206</eissn><abstract>Due to the destruction of the integrity of the parent crystal, single‐crystal‐to‐single‐crystal phase transition in organic compounds is still a relatively rare phenomenon. The phase transition in glycyrrhetinic acid isopropyl ester is triggered by temperature change. The increasing volume of the isopropyl substituent as a result of increasing temperature forces a remodelling of the structural motifs. These changes cause a single‐crystal‐to‐single‐crystal phase transition. The low‐temperature form is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with the ethyl ester of this acid.
The single‐crystal‐to‐single‐crystal phase transition observed for glycyrrhetinic acid isopropyl ester is triggered by temperature change and causes the rebuilding of the structural motifs. The low‐temperature phase is isostructural with glycyrrhetinic acid methanol solvate, while the high‐temperature phase is isostructural with glycyrrhetinic acid ethyl ester.</abstract><cop>5 Abbey Square, Chester, Cheshire CH1 2HU, England</cop><pub>International Union of Crystallography</pub><pmid>35702962</pmid><doi>10.1107/S2052520622002517</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8659-8119</orcidid><orcidid>https://orcid.org/0000-0003-2254-2508</orcidid><orcidid>https://orcid.org/0000-0001-9393-3536</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Crystal structure differential scanning calorimetry DSC Ethyl esters glycyrrhetinic acid Organic compounds phase transition Phase transitions triterpene |
| title | Single‐crystal‐to‐single‐crystal phase transition of 18β‐glycyrrhetinic acid isopropyl ester |
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