Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy
To investigate the protein expression levels of cyclin‐dependent kinase subunit 2 (CKS2) and the cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significance. A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 pat...
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| Veröffentlicht in: | Scandinavian journal of immunology 2022-10, Vol.96 (4), p.e13198-n/a |
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| creator | Zhou, Yang Zeng, Jing Zhou, Wei Wu, Keyan Tian, Zhen Shen, Weigan |
| description | To investigate the protein expression levels of cyclin‐dependent kinase subunit 2 (CKS2) and the cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significance. A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumour, 42 patients with low‐grade intraepithelial neoplasia (LGIEN), and 49 patients with high‐grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analysed the clinical significance of the expression of the two factors. (1) The positivity rates for CKS2 in benign gastric tumour tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, that is, 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumour diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r = .625, P = .000). (3) The median follow‐up time of 126 patients was 46.5 months, and the overall survival (OS) rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (−) group, the OS rate for patients in the CKS2 (+) group was significantly worse and that compared with the CD47 (−) group, the CD47 (+) group had significantly worse OS (30.1% vs 60.5%, χ2 = 15.67, P = .000). (4) The OS rates of CKS2 (+) CD47 (+) group, CKS2 (+) CD47 (−) group, CKS2 (−) CD47 (+) group, and CKS2 (−) CD47 (−) group were 20.0% (13/65), 58.3% (7/12), 57.1% (8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2 (+) CD47 (+) group was significantly poor. High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients. |
| doi_str_mv | 10.1111/sji.13198 |
| format | Article |
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A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumour, 42 patients with low‐grade intraepithelial neoplasia (LGIEN), and 49 patients with high‐grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analysed the clinical significance of the expression of the two factors. (1) The positivity rates for CKS2 in benign gastric tumour tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, that is, 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumour diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r = .625, P = .000). (3) The median follow‐up time of 126 patients was 46.5 months, and the overall survival (OS) rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (−) group, the OS rate for patients in the CKS2 (+) group was significantly worse and that compared with the CD47 (−) group, the CD47 (+) group had significantly worse OS (30.1% vs 60.5%, χ2 = 15.67, P = .000). (4) The OS rates of CKS2 (+) CD47 (+) group, CKS2 (+) CD47 (−) group, CKS2 (−) CD47 (+) group, and CKS2 (−) CD47 (−) group were 20.0% (13/65), 58.3% (7/12), 57.1% (8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2 (+) CD47 (+) group was significantly poor. High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/sji.13198</identifier><identifier>PMID: 35703112</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>cluster of differentiation 47 ; cyclin‐dependent protein kinase ; Gastrectomy ; Gastric cancer ; Immunohistochemistry ; Lymph nodes ; Medical prognosis ; Metastases ; Patients ; Prognosis ; Risk factors ; Survival ; Survival analysis ; Tumors</subject><ispartof>Scandinavian journal of immunology, 2022-10, Vol.96 (4), p.e13198-n/a</ispartof><rights>2022 The Scandinavian Foundation for Immunology.</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>Copyright © 2022 The Scandinavian Foundation for Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-51c9f852f82369a7b9c2325f497c6a19a20c7aab2d016acceb3140c71e5661193</citedby><cites>FETCH-LOGICAL-c3888-51c9f852f82369a7b9c2325f497c6a19a20c7aab2d016acceb3140c71e5661193</cites><orcidid>0000-0003-1446-2719</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsji.13198$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsji.13198$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35703112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Zeng, Jing</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Wu, Keyan</creatorcontrib><creatorcontrib>Tian, Zhen</creatorcontrib><creatorcontrib>Shen, Weigan</creatorcontrib><title>Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>To investigate the protein expression levels of cyclin‐dependent kinase subunit 2 (CKS2) and the cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significance. A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumour, 42 patients with low‐grade intraepithelial neoplasia (LGIEN), and 49 patients with high‐grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analysed the clinical significance of the expression of the two factors. (1) The positivity rates for CKS2 in benign gastric tumour tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, that is, 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumour diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r = .625, P = .000). (3) The median follow‐up time of 126 patients was 46.5 months, and the overall survival (OS) rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (−) group, the OS rate for patients in the CKS2 (+) group was significantly worse and that compared with the CD47 (−) group, the CD47 (+) group had significantly worse OS (30.1% vs 60.5%, χ2 = 15.67, P = .000). (4) The OS rates of CKS2 (+) CD47 (+) group, CKS2 (+) CD47 (−) group, CKS2 (−) CD47 (+) group, and CKS2 (−) CD47 (−) group were 20.0% (13/65), 58.3% (7/12), 57.1% (8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2 (+) CD47 (+) group was significantly poor. High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.</description><subject>cluster of differentiation 47</subject><subject>cyclin‐dependent protein kinase</subject><subject>Gastrectomy</subject><subject>Gastric cancer</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Tumors</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kcFOGzEQhq0KVELaQ1-gssQFDgseT3a9PqLQAgWplWjPluP1BkcbO9i7Cnn7miz0UIm5jDT65tNofkK-ADuHXBdp5c4BQdYfyASwKgtkNR6QCUPGCjkT5RE5TmnFGCAX-JEcYSkYAvAJGX7FsPQh9c7Q5Jbetc5obywNLZ3fPXCqfUPnVzNB7fMm2pRc8NR5utG9s75PdOv6R7rUqY_ZsF-NdPsY6OAbG7cZoVE32dmNkDV9WO8-kcNWd8l-fu1T8uf7t9_zm-L-5_Xt_PK-MFjXdVGCkW1d8rbmWEktFtJw5GU7k8JUGqTmzAitF7xhUGlj7AJhlkdgy6oCkDglp6N3E8PTYFOv1i4Z23Xa2zAkxStRSY6IkNGT_9BVGKLP1yku8nOxZBmckrORMjGkFG2rNtGtddwpYOolC5WzUPssMvv11Tgs1rb5R749PwMXI7B1nd29b1IPP25H5V9cKZKZ</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Zhou, Yang</creator><creator>Zeng, Jing</creator><creator>Zhou, Wei</creator><creator>Wu, Keyan</creator><creator>Tian, Zhen</creator><creator>Shen, Weigan</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1446-2719</orcidid></search><sort><creationdate>202210</creationdate><title>Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy</title><author>Zhou, Yang ; Zeng, Jing ; Zhou, Wei ; Wu, Keyan ; Tian, Zhen ; Shen, Weigan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3888-51c9f852f82369a7b9c2325f497c6a19a20c7aab2d016acceb3140c71e5661193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cluster of differentiation 47</topic><topic>cyclin‐dependent protein kinase</topic><topic>Gastrectomy</topic><topic>Gastric cancer</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Zeng, Jing</creatorcontrib><creatorcontrib>Zhou, Wei</creatorcontrib><creatorcontrib>Wu, Keyan</creatorcontrib><creatorcontrib>Tian, Zhen</creatorcontrib><creatorcontrib>Shen, Weigan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Yang</au><au>Zeng, Jing</au><au>Zhou, Wei</au><au>Wu, Keyan</au><au>Tian, Zhen</au><au>Shen, Weigan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>2022-10</date><risdate>2022</risdate><volume>96</volume><issue>4</issue><spage>e13198</spage><epage>n/a</epage><pages>e13198-n/a</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>To investigate the protein expression levels of cyclin‐dependent kinase subunit 2 (CKS2) and the cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significance. A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumour, 42 patients with low‐grade intraepithelial neoplasia (LGIEN), and 49 patients with high‐grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analysed the clinical significance of the expression of the two factors. (1) The positivity rates for CKS2 in benign gastric tumour tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, that is, 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumour diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r = .625, P = .000). (3) The median follow‐up time of 126 patients was 46.5 months, and the overall survival (OS) rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (−) group, the OS rate for patients in the CKS2 (+) group was significantly worse and that compared with the CD47 (−) group, the CD47 (+) group had significantly worse OS (30.1% vs 60.5%, χ2 = 15.67, P = .000). (4) The OS rates of CKS2 (+) CD47 (+) group, CKS2 (+) CD47 (−) group, CKS2 (−) CD47 (+) group, and CKS2 (−) CD47 (−) group were 20.0% (13/65), 58.3% (7/12), 57.1% (8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2 (+) CD47 (+) group was significantly poor. High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35703112</pmid><doi>10.1111/sji.13198</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1446-2719</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | cluster of differentiation 47 cyclin‐dependent protein kinase Gastrectomy Gastric cancer Immunohistochemistry Lymph nodes Medical prognosis Metastases Patients Prognosis Risk factors Survival Survival analysis Tumors |
| title | Prognostic significance of CKS2 and CD47 expression in patients with gastric cancer who underwent radical gastrectomy |
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