Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Remarkable advances have been made in schizophrenia (SCZ) GWAS, but gleaning biological insight from these loci is challenging. Genetic influences on gene expression (e.g., eQTLs) are cell type-specific, but most studies that attempt to clarify GWAS loci’s influence on gene expression have employed...

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Veröffentlicht in:	Molecular psychiatry 2022-10, Vol.27 (10), p.4218-4233
Hauptverfasser:	Liu, Dongxin, Zinski, Amy, Mishra, Akanksha, Noh, Haneul, Park, Gun-Hoo, Qin, Yiren, Olorife, Oshoname, Park, James M., Abani, Chiderah P., Park, Joy S., Fung, Janice, Sawaqed, Farah, Coyle, Joseph T., Stahl, Eli, Bendl, Jaroslav, Fullard, John F., Roussos, Panos, Zhang, Xiaolei, Stanton, Patric K., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Won, Hyejung, Cho, Jun-Hyeong, Chung, Sangmi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/51 14/19 14/35 38/22 38/39 38/43 38/47 38/77 38/89 45/44 45/91 631/378 631/477 631/532 82/29 82/51 9/74 96/44 Animals ATP2A2 gene Behavioral Sciences Biological Psychology Brain - metabolism Calcium currents Fetuses Gene expression Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Glutamatergic transmission Heritability Humans Hyperactivity Interneurons Interneurons - metabolism Medicine Medicine & Public Health Mental disorders Mice Neurogenesis Neurons - metabolism Neurosciences Pharmacotherapy Psychiatry Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Therapeutic targets Transplantation
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