Clonidine ameliorates cisplatin-induced nephrotoxicity: impact on OCT2 and p38 MAPK pathway

Abstract Objectives To explore clonidine (Clon) nephroprotective effects as an inhibitor of organic cationic transporter 2 (OCT2) and p38 mitogen-activated protein kinase (p38 MAPK) against cisplatin (CP)-induced nephrotoxicity. OCT2 is mainly responsible for renal accumulation of CP. Clon has been...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2022-08, Vol.74 (8), p.1180-1192
Hauptverfasser:	Fawzy, Mariam H, Khodeer, Dina M, Elsayed, Norhan M, Ahmed, Yasser M, Saeed, Noha M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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