Prospects for Improving the Extent of Recovery following Peripheral Nerve Trauma: A Review

Prospects for Improving the Extent of Recovery following Peripheral Nerve Trauma: A Review

Restoring function to damaged peripheral nerves with a gap remains challenging, with

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Veröffentlicht in:Puerto Rico health sciences journal 2022-06, Vol.41 (2), p.89-95
Hauptverfasser: Foy, Christian, Olivella, Gerardo, Kuffler, Damien
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creator Foy, Christian
Olivella, Gerardo
Kuffler, Damien
description Restoring function to damaged peripheral nerves with a gap remains challenging, with
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Further, despite enormous efforts to improve existing techniques and develop new ones, the percentage of patients who recover function and their extent of recovery has not increased in almost 70 years. Thus, although sensory nerve grafts remain the clinical "gold standard" technique for attempting to restore function to nerves with a gap, they have significant limitations. They are effective in restoring good to excellent function only for gaps &lt;3-5 cm, repairs performed &lt;3-5 months post-trauma, and patients &lt;20-25 years old. As the value of any of these variables increases, the extent of recovery decreases precipitously, and if the values of two or all three variables increase, there is little to no recovery. Therefore, novel techniques are required that increase the percentage of patients who recover function and the extent of their recovery. This review discusses the limitations of sensory nerve grafts and other techniques currently being used to repair nerves. It also discusses the use of autologous platelet-rich plasma (PRP), which appears to be the most promising technique for inducing sensory and motor recovery even when the values of all three variables are significantly greater than when sensory nerve grafts alone are not effective. 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title Prospects for Improving the Extent of Recovery following Peripheral Nerve Trauma: A Review
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