A comprehensive, tri‐national, cross‐sectional analysis of characteristics and impact of pruritus in psoriasis
Background Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized. Objective To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis. Methods Thi...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2022-11, Vol.36 (11), p.2064-2075 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
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| creator | Hawro, M. Sahin, E. Steć, M. Różewicka‐Czabańska, M. Raducha, E. Garanyan, L. Philipp, S. Kokolakis, G. Christou, D. Kolkhir, P. Pogorelov, D. Weller, K. Metz, M. Sabat, R. Maleszka, R. Olisova, O. Maurer, M. Hawro, T. |
| description | Background
Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized.
Objective
To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis.
Methods
This cross‐sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self‐reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps.
Results
Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho = 0.278; P |
| doi_str_mv | 10.1111/jdv.18330 |
| format | Article |
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Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized.
Objective
To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis.
Methods
This cross‐sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self‐reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps.
Results
Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho = 0.278; P < 0.001). One third of patients (31%) reported impaired sex‐life, and 4% had suicidal ideations due to pruritus. In up to one third of patients, psoriasis therapies had little or no effect on pruritus. The only therapeutic option offered to some of these patients were antihistamines, which appeared to be effective in most cases.
Conclusion
Pruritus is highly prevalent in psoriasis and is linked to a significant burden. Current psoriasis therapies are frequently insufficient to control pruritus. Managing psoriasis should include the assessment and control of itch. Efficient antipruritic therapies should be developed and be made available for patients with psoriasis.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.18330</identifier><identifier>PMID: 35699348</identifier><language>eng</language><publisher>England</publisher><ispartof>Journal of the European Academy of Dermatology and Venereology, 2022-11, Vol.36 (11), p.2064-2075</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3600-7093f19492e034f809c8ecd2d196b8d12bee2a7e05d71d71180cf68fa6831a0b3</citedby><cites>FETCH-LOGICAL-c3600-7093f19492e034f809c8ecd2d196b8d12bee2a7e05d71d71180cf68fa6831a0b3</cites><orcidid>0000-0002-4121-481X ; 0000-0001-9990-1332 ; 0000-0003-4437-0313 ; 0000-0003-1537-2221 ; 0000-0002-4070-9976 ; 0000-0002-8042-7885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.18330$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.18330$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35699348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawro, M.</creatorcontrib><creatorcontrib>Sahin, E.</creatorcontrib><creatorcontrib>Steć, M.</creatorcontrib><creatorcontrib>Różewicka‐Czabańska, M.</creatorcontrib><creatorcontrib>Raducha, E.</creatorcontrib><creatorcontrib>Garanyan, L.</creatorcontrib><creatorcontrib>Philipp, S.</creatorcontrib><creatorcontrib>Kokolakis, G.</creatorcontrib><creatorcontrib>Christou, D.</creatorcontrib><creatorcontrib>Kolkhir, P.</creatorcontrib><creatorcontrib>Pogorelov, D.</creatorcontrib><creatorcontrib>Weller, K.</creatorcontrib><creatorcontrib>Metz, M.</creatorcontrib><creatorcontrib>Sabat, R.</creatorcontrib><creatorcontrib>Maleszka, R.</creatorcontrib><creatorcontrib>Olisova, O.</creatorcontrib><creatorcontrib>Maurer, M.</creatorcontrib><creatorcontrib>Hawro, T.</creatorcontrib><title>A comprehensive, tri‐national, cross‐sectional analysis of characteristics and impact of pruritus in psoriasis</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized.
Objective
To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis.
Methods
This cross‐sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self‐reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps.
Results
Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho = 0.278; P < 0.001). One third of patients (31%) reported impaired sex‐life, and 4% had suicidal ideations due to pruritus. In up to one third of patients, psoriasis therapies had little or no effect on pruritus. The only therapeutic option offered to some of these patients were antihistamines, which appeared to be effective in most cases.
Conclusion
Pruritus is highly prevalent in psoriasis and is linked to a significant burden. Current psoriasis therapies are frequently insufficient to control pruritus. Managing psoriasis should include the assessment and control of itch. Efficient antipruritic therapies should be developed and be made available for patients with psoriasis.</description><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kM1KAzEUhYMotlYXvoBkqdCxyaRJk2Wp_xTcqNshzdyhKfNnMlPpzkfwGX0S0051Zwi5cM53D-QgdE7JNQ1ntErX11QyRg5Qn46FjBiR7BD1iYpFpBRXPXTi_YoQQimXx6jHuFCKjWUfuSk2VVE7WELp7RqGuHH2-_Or1I2tSp0PsXGV90HxYDoJ6_BsvPW4yrBZaqdNA876xhofvBTbog7S1q1d62zTemxLXPvKWR3WTtFRpnMPZ_s5QK93ty-zh2j-fP84m84jwwQh0YQollE1VjEQNs4kUUaCSeOUKrGQKY0XALGeAOHphIZLJTGZkJkWklFNFmyALrvc2lXvLfgmKaw3kOe6hKr1SSwmgnMecx7Qqw7dfdZBltTOFtptEkqSbcVJqDjZVRzYi31suygg_SN_Ow3AqAM-bA6b_5OSp5u3LvIHIqOJRw</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Hawro, M.</creator><creator>Sahin, E.</creator><creator>Steć, M.</creator><creator>Różewicka‐Czabańska, M.</creator><creator>Raducha, E.</creator><creator>Garanyan, L.</creator><creator>Philipp, S.</creator><creator>Kokolakis, G.</creator><creator>Christou, D.</creator><creator>Kolkhir, P.</creator><creator>Pogorelov, D.</creator><creator>Weller, K.</creator><creator>Metz, M.</creator><creator>Sabat, R.</creator><creator>Maleszka, R.</creator><creator>Olisova, O.</creator><creator>Maurer, M.</creator><creator>Hawro, T.</creator><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4121-481X</orcidid><orcidid>https://orcid.org/0000-0001-9990-1332</orcidid><orcidid>https://orcid.org/0000-0003-4437-0313</orcidid><orcidid>https://orcid.org/0000-0003-1537-2221</orcidid><orcidid>https://orcid.org/0000-0002-4070-9976</orcidid><orcidid>https://orcid.org/0000-0002-8042-7885</orcidid></search><sort><creationdate>202211</creationdate><title>A comprehensive, tri‐national, cross‐sectional analysis of characteristics and impact of pruritus in psoriasis</title><author>Hawro, M. ; Sahin, E. ; Steć, M. ; Różewicka‐Czabańska, M. ; Raducha, E. ; Garanyan, L. ; Philipp, S. ; Kokolakis, G. ; Christou, D. ; Kolkhir, P. ; Pogorelov, D. ; Weller, K. ; Metz, M. ; Sabat, R. ; Maleszka, R. ; Olisova, O. ; Maurer, M. ; Hawro, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3600-7093f19492e034f809c8ecd2d196b8d12bee2a7e05d71d71180cf68fa6831a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawro, M.</creatorcontrib><creatorcontrib>Sahin, E.</creatorcontrib><creatorcontrib>Steć, M.</creatorcontrib><creatorcontrib>Różewicka‐Czabańska, M.</creatorcontrib><creatorcontrib>Raducha, E.</creatorcontrib><creatorcontrib>Garanyan, L.</creatorcontrib><creatorcontrib>Philipp, S.</creatorcontrib><creatorcontrib>Kokolakis, G.</creatorcontrib><creatorcontrib>Christou, D.</creatorcontrib><creatorcontrib>Kolkhir, P.</creatorcontrib><creatorcontrib>Pogorelov, D.</creatorcontrib><creatorcontrib>Weller, K.</creatorcontrib><creatorcontrib>Metz, M.</creatorcontrib><creatorcontrib>Sabat, R.</creatorcontrib><creatorcontrib>Maleszka, R.</creatorcontrib><creatorcontrib>Olisova, O.</creatorcontrib><creatorcontrib>Maurer, M.</creatorcontrib><creatorcontrib>Hawro, T.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawro, M.</au><au>Sahin, E.</au><au>Steć, M.</au><au>Różewicka‐Czabańska, M.</au><au>Raducha, E.</au><au>Garanyan, L.</au><au>Philipp, S.</au><au>Kokolakis, G.</au><au>Christou, D.</au><au>Kolkhir, P.</au><au>Pogorelov, D.</au><au>Weller, K.</au><au>Metz, M.</au><au>Sabat, R.</au><au>Maleszka, R.</au><au>Olisova, O.</au><au>Maurer, M.</au><au>Hawro, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comprehensive, tri‐national, cross‐sectional analysis of characteristics and impact of pruritus in psoriasis</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2022-11</date><risdate>2022</risdate><volume>36</volume><issue>11</issue><spage>2064</spage><epage>2075</epage><pages>2064-2075</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized.
Objective
To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis.
Methods
This cross‐sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self‐reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps.
Results
Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho = 0.278; P < 0.001). One third of patients (31%) reported impaired sex‐life, and 4% had suicidal ideations due to pruritus. In up to one third of patients, psoriasis therapies had little or no effect on pruritus. The only therapeutic option offered to some of these patients were antihistamines, which appeared to be effective in most cases.
Conclusion
Pruritus is highly prevalent in psoriasis and is linked to a significant burden. Current psoriasis therapies are frequently insufficient to control pruritus. Managing psoriasis should include the assessment and control of itch. Efficient antipruritic therapies should be developed and be made available for patients with psoriasis.</abstract><cop>England</cop><pmid>35699348</pmid><doi>10.1111/jdv.18330</doi><tpages>2075</tpages><orcidid>https://orcid.org/0000-0002-4121-481X</orcidid><orcidid>https://orcid.org/0000-0001-9990-1332</orcidid><orcidid>https://orcid.org/0000-0003-4437-0313</orcidid><orcidid>https://orcid.org/0000-0003-1537-2221</orcidid><orcidid>https://orcid.org/0000-0002-4070-9976</orcidid><orcidid>https://orcid.org/0000-0002-8042-7885</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| title | A comprehensive, tri‐national, cross‐sectional analysis of characteristics and impact of pruritus in psoriasis |
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