The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus
Purpose To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM). Materials and methods This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated base...
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| Veröffentlicht in: | Endocrine 2022-08, Vol.77 (2), p.242-251 |
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| creator | Li, Zelin Qi, Cuijuan Pan, Xiaoyu Jia, Yujiao Zhao, Xuetong Deng, Chenqian Chen, Shuchun |
| description | Purpose
To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).
Materials and methods
This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.
Results
The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.
Conclusion
Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM. |
| doi_str_mv | 10.1007/s12020-022-03090-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2676552885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2695012861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-137a52447ddf455646193e9cda9d092d5d27af7b0e0beaf20cbd9a3506968dbe3</originalsourceid><addsrcrecordid>eNp9kctu1jAQhS1ERS_wAiyQJTZsQsdO7PxeogooUiU27dpy4kmbktjBk4Dap2fKXy5iwcqW5zvHM2eEeKngrQJoT0lp0FCB1hXU4KC6fyKOlDGuAq4__et-KI6JboFJbdtn4rA21rXONkciXd6gLDiFdcyJbsZFdrh-R0wSaR3nsGKU19PWZ0IZR1oyhUkWfpYhRdnlhHLdSsrfsMg5lC9YSI5JrncLSs2KwHZIcsZpGteNnouDIUyELx7PE3H14f3l2Xl18fnjp7N3F1Vft2atVN0Go5umjXFojLGNVa5G18fgIjgdTdRtGNoOEDoMg4a-iy7UBqyzu9hhfSLe7H2Xkr9uPIqfR-q5iZAwb-Q5BmuM3u0Mo6__QW8zT8TdMeUMKL2ziim9p_qSiQoOfikcT7nzCvzDNvx-G54z9j-34e9Z9OrReutmjL8lv-JnoN4DxKV0jeXP3_-x_QGLV5bh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2695012861</pqid></control><display><type>article</type><title>The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus</title><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Zelin ; Qi, Cuijuan ; Pan, Xiaoyu ; Jia, Yujiao ; Zhao, Xuetong ; Deng, Chenqian ; Chen, Shuchun</creator><creatorcontrib>Li, Zelin ; Qi, Cuijuan ; Pan, Xiaoyu ; Jia, Yujiao ; Zhao, Xuetong ; Deng, Chenqian ; Chen, Shuchun</creatorcontrib><description>Purpose
To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).
Materials and methods
This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.
Results
The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.
Conclusion
Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM.</description><identifier>ISSN: 1559-0100</identifier><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-022-03090-z</identifier><identifier>PMID: 35697964</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Body mass index ; Bone turnover ; Collagen (type I) ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Endocrinology ; Females ; Hemoglobin ; Humanities and Social Sciences ; Insulin ; Insulin resistance ; Internal Medicine ; Medicine ; Medicine & Public Health ; multidisciplinary ; Original Article ; Osteocalcin ; Peptides ; Post-menopause ; Procollagen ; Science</subject><ispartof>Endocrine, 2022-08, Vol.77 (2), p.242-251</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-137a52447ddf455646193e9cda9d092d5d27af7b0e0beaf20cbd9a3506968dbe3</citedby><cites>FETCH-LOGICAL-c375t-137a52447ddf455646193e9cda9d092d5d27af7b0e0beaf20cbd9a3506968dbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-022-03090-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-022-03090-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35697964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zelin</creatorcontrib><creatorcontrib>Qi, Cuijuan</creatorcontrib><creatorcontrib>Pan, Xiaoyu</creatorcontrib><creatorcontrib>Jia, Yujiao</creatorcontrib><creatorcontrib>Zhao, Xuetong</creatorcontrib><creatorcontrib>Deng, Chenqian</creatorcontrib><creatorcontrib>Chen, Shuchun</creatorcontrib><title>The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).
Materials and methods
This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.
Results
The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.
Conclusion
Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM.</description><subject>Body mass index</subject><subject>Bone turnover</subject><subject>Collagen (type I)</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Endocrinology</subject><subject>Females</subject><subject>Hemoglobin</subject><subject>Humanities and Social Sciences</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Original Article</subject><subject>Osteocalcin</subject><subject>Peptides</subject><subject>Post-menopause</subject><subject>Procollagen</subject><subject>Science</subject><issn>1559-0100</issn><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1jAQhS1ERS_wAiyQJTZsQsdO7PxeogooUiU27dpy4kmbktjBk4Dap2fKXy5iwcqW5zvHM2eEeKngrQJoT0lp0FCB1hXU4KC6fyKOlDGuAq4__et-KI6JboFJbdtn4rA21rXONkciXd6gLDiFdcyJbsZFdrh-R0wSaR3nsGKU19PWZ0IZR1oyhUkWfpYhRdnlhHLdSsrfsMg5lC9YSI5JrncLSs2KwHZIcsZpGteNnouDIUyELx7PE3H14f3l2Xl18fnjp7N3F1Vft2atVN0Go5umjXFojLGNVa5G18fgIjgdTdRtGNoOEDoMg4a-iy7UBqyzu9hhfSLe7H2Xkr9uPIqfR-q5iZAwb-Q5BmuM3u0Mo6__QW8zT8TdMeUMKL2ziim9p_qSiQoOfikcT7nzCvzDNvx-G54z9j-34e9Z9OrReutmjL8lv-JnoN4DxKV0jeXP3_-x_QGLV5bh</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Li, Zelin</creator><creator>Qi, Cuijuan</creator><creator>Pan, Xiaoyu</creator><creator>Jia, Yujiao</creator><creator>Zhao, Xuetong</creator><creator>Deng, Chenqian</creator><creator>Chen, Shuchun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220801</creationdate><title>The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus</title><author>Li, Zelin ; Qi, Cuijuan ; Pan, Xiaoyu ; Jia, Yujiao ; Zhao, Xuetong ; Deng, Chenqian ; Chen, Shuchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-137a52447ddf455646193e9cda9d092d5d27af7b0e0beaf20cbd9a3506968dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Body mass index</topic><topic>Bone turnover</topic><topic>Collagen (type I)</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Endocrinology</topic><topic>Females</topic><topic>Hemoglobin</topic><topic>Humanities and Social Sciences</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Original Article</topic><topic>Osteocalcin</topic><topic>Peptides</topic><topic>Post-menopause</topic><topic>Procollagen</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zelin</creatorcontrib><creatorcontrib>Qi, Cuijuan</creatorcontrib><creatorcontrib>Pan, Xiaoyu</creatorcontrib><creatorcontrib>Jia, Yujiao</creatorcontrib><creatorcontrib>Zhao, Xuetong</creatorcontrib><creatorcontrib>Deng, Chenqian</creatorcontrib><creatorcontrib>Chen, Shuchun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zelin</au><au>Qi, Cuijuan</au><au>Pan, Xiaoyu</au><au>Jia, Yujiao</au><au>Zhao, Xuetong</au><au>Deng, Chenqian</au><au>Chen, Shuchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>77</volume><issue>2</issue><spage>242</spage><epage>251</epage><pages>242-251</pages><issn>1559-0100</issn><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).
Materials and methods
This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.
Results
The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.
Conclusion
Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35697964</pmid><doi>10.1007/s12020-022-03090-z</doi><tpages>10</tpages></addata></record> |
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| subjects | Body mass index Bone turnover Collagen (type I) Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology Females Hemoglobin Humanities and Social Sciences Insulin Insulin resistance Internal Medicine Medicine Medicine & Public Health multidisciplinary Original Article Osteocalcin Peptides Post-menopause Procollagen Science |
| title | The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus |
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