Exosomes deliver lncRNA DARS-AS1 siRNA to inhibit chronic unpredictable mild stress-induced TNBC metastasis

Triple-negative breast cancer (TNBC) is a rapidly recurring and highly metastatic malignancy with high heterogeneity and chemoradiotherapy resistance. Chronic unpredictable mild stress (CUMS) can induce the occurrence of tumors and enhance lymphatic infiltration and distant metastasis through direct...

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Veröffentlicht in:	Cancer letters 2022-09, Vol.543, p.215781-215781, Article 215781
Hauptverfasser:	Liu, Xinli, Zhang, Ge, Yu, Tongyao, He, Jinliang, Liu, Jie, Chai, Xiaoxia, Zhao, Gang, Yin, Dachuan, Zhang, Chenyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Breast cancer Breast cancer liver metastasis (BCLM) Cancer therapies CDK1 Cell adhesion & migration Chemoradiotherapy Chronic unpredictable mild stress (CUMS) Data analysis Drug delivery systems Exosomes Gene expression Hepatocytes Homeostasis Long non-coding RNA DARS-AS1 (DARS-AS1) Malignancy Metastases Metastasis NF-κB protein Non-coding RNA Radiation therapy Signal transduction siRNA siRNA-loaded exosomes Software Stat3 protein Surgery Sympathetic nervous system Therapeutic targets Tumors
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