TRPV1+ sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling

Timely initiation and termination of inflammatory response after corneal epithelial abrasion is critical for the recovery of vision. The cornea is innervated with rich sensory nerves with highly dense TRPV1 nociceptors. However, the roles of TRPV1+ sensory neurons in corneal inflammation after epith...

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Veröffentlicht in:	Mucosal immunology 2022-05, Vol.15 (5), p.867-881
Hauptverfasser:	Liu, Jun, Huang, Shuoya, Yu, Ruoxun, Chen, Xinwei, Li, Fanying, Sun, Xin, Xu, Pengyang, Huang, Yijia, Xue, Yunxia, Fu, Ting, Li, Zhijie
Format:	Artikel
Sprache:	eng
Schlagworte:	Abrasion Allergology Animals Antibodies Biomedical and Life Sciences Biomedicine Capsaicin receptors CCR2 protein Cornea Corneal Injuries Gastroenterology Immunology Inflammation Interleukin 10 Leukocytes (neutrophilic) Lymphocytes T Macrophages Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Neuropathy Neutrophils Nociceptors Pain perception Physical growth Receptor activity modifying proteins Receptor Activity-Modifying Protein 1 - metabolism Receptors, Somatostatin - metabolism Resiniferatoxin Sensory neurons TRPV Cation Channels - metabolism Tumor necrosis factor-α Wound Healing
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