Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators

Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associating Domain Boundaries (TADBs). BD2-selective and pan (non-sel...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2022-08, Vol.152, p.113230-113230, Article 113230
Hauptverfasser:	Tsujikawa, Laura M., Kharenko, Olesya A., Stotz, Stephanie C., Rakai, Brooke D., Sarsons, Christopher D., Gilham, Dean, Wasiak, Sylwia, Fu, Li, Sweeney, Michael, Johansson, Jan O., Wong, Norman C.W., Kulikowski, Ewelina
Format:	Artikel
Sprache:	eng
Schlagworte:	BET inhibitors BRD4 Chromatin structure DNA repair TAD boundaries YY1
Online-Zugang:	Volltext
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