A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes
Radish ( Raphanus sativus L.) is a rich source of nutrients and its greens have reported functionalities. This study aimed to investigate the effects of a water-soluble extract from radish greens (WERG) on adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obesity in model mice. We also qua...
Gespeichert in:
| Veröffentlicht in: | Food & function 2022-07, Vol.13 (14), p.7494-756 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 756 |
|---|---|
| container_issue | 14 |
| container_start_page | 7494 |
| container_title | Food & function |
| container_volume | 13 |
| creator | Oh, Mi-Jin Lee, Hyun Hee L Lee, Hye-Bin Do, Moon Ho Park, Miri Lee, Chang-Hyun Park, Ho-Young |
| description | Radish (
Raphanus sativus
L.) is a rich source of nutrients and its greens have reported functionalities. This study aimed to investigate the effects of a water-soluble extract from radish greens (WERG) on adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obesity in model mice. We also quantified the phytochemical composition of WERG such as glucoraphenin and ferulic acid. These findings show that treatment with 100 μg mL
−1
WERG reduced lipid accumulation in 3T3-L1 adipocytes, whereas in mice, the administration of 100 mg kg
−1
WERG reduced weight gain and hepatic lipid accumulation and improved the levels of serum lipid biomarkers. Furthermore, WERG treatment improved intestinal permeability and suppressed the activities of harmful intestinal enzymes in feces, thus improving gut health. It also inhibited metabolic endotoxemia and inflammatory marker levels in serum. Moreover, WERG reduced the expression of lipid-metabolism-related proteins in the liver and white adipose tissue. Collectively, these results indicate that WERG may potentiate the anti-obesity effect by improving gut health and regulating lipid metabolism.
A water-soluble extract from radish greens (WERG) inhibits adipogenesis in 3T3-L1 adipocytes and ameliorates high fat diet-induced obesity in mice. |
| doi_str_mv | 10.1039/d1fo04152e |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2675604801</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2675604801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-bea3176509377bbcd720dd4229b78695dc376c53b6b5649b1c66671fff0202be3</originalsourceid><addsrcrecordid>eNpd0U1LHDEYB_AgFRXrpfeWQC9SmJqXmWRyFF8LgheF3oa8PLMbmZlskwy6H8Dv3bjrWmguCckvD3nyR-gLJT8p4erM0T6QmjYM9tARIzWrREN-f9qtayUO0UlKT6QMrlSr2gN0yBvRCkHqI_R6jp91hohTGGYzAIaXHLXNOPQ4aufTEi8iwJSwHmHwIRac8NIvlrjXGTsPufKTmy04HAwkn9fYT3j0FrCeXFkvvfG5XHd-FRYwFZLexCrCZsuuS8HPaL_XQ4KT9_kYPV5fPVzcVnf3N78uzu8qy2WbKwOaU1n6U1xKY6yTjDhXM6aMbIVqXGHCNtwI05TODbVCCEn7vieMMAP8GJ1u665i-DNDyt3ok4Vh0BOEOXVMyKZ8S0tood__o09hjlN5XVGKklY2NSnqx1bZGFKK0Her6Ecd1x0l3Vs-3SW9vt_kc1Xwt_eSsxnBfdBdGgV83YKY7Mfpv4D5X8z9lYk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2691087540</pqid></control><display><type>article</type><title>A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes</title><source>Royal Society Of Chemistry Journals</source><creator>Oh, Mi-Jin ; Lee, Hyun Hee L ; Lee, Hye-Bin ; Do, Moon Ho ; Park, Miri ; Lee, Chang-Hyun ; Park, Ho-Young</creator><creatorcontrib>Oh, Mi-Jin ; Lee, Hyun Hee L ; Lee, Hye-Bin ; Do, Moon Ho ; Park, Miri ; Lee, Chang-Hyun ; Park, Ho-Young</creatorcontrib><description>Radish (
Raphanus sativus
L.) is a rich source of nutrients and its greens have reported functionalities. This study aimed to investigate the effects of a water-soluble extract from radish greens (WERG) on adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obesity in model mice. We also quantified the phytochemical composition of WERG such as glucoraphenin and ferulic acid. These findings show that treatment with 100 μg mL
−1
WERG reduced lipid accumulation in 3T3-L1 adipocytes, whereas in mice, the administration of 100 mg kg
−1
WERG reduced weight gain and hepatic lipid accumulation and improved the levels of serum lipid biomarkers. Furthermore, WERG treatment improved intestinal permeability and suppressed the activities of harmful intestinal enzymes in feces, thus improving gut health. It also inhibited metabolic endotoxemia and inflammatory marker levels in serum. Moreover, WERG reduced the expression of lipid-metabolism-related proteins in the liver and white adipose tissue. Collectively, these results indicate that WERG may potentiate the anti-obesity effect by improving gut health and regulating lipid metabolism.
A water-soluble extract from radish greens (WERG) inhibits adipogenesis in 3T3-L1 adipocytes and ameliorates high fat diet-induced obesity in mice.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo04152e</identifier><identifier>PMID: 35686604</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Accumulation ; Adipocytes ; Adipogenesis ; Adipose tissue ; Animal models ; Biomarkers ; Body weight gain ; Diet ; Digestive system ; Endotoxemia ; Ferulic acid ; Gastrointestinal tract ; High fat diet ; Inflammation ; Intestine ; Lipid metabolism ; Lipids ; Metabolism ; Nutrients ; Obesity ; Permeability ; Preadipocytes ; Radishes ; Raphanus sativus ; Water chemistry ; Weight reduction</subject><ispartof>Food & function, 2022-07, Vol.13 (14), p.7494-756</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-bea3176509377bbcd720dd4229b78695dc376c53b6b5649b1c66671fff0202be3</citedby><cites>FETCH-LOGICAL-c378t-bea3176509377bbcd720dd4229b78695dc376c53b6b5649b1c66671fff0202be3</cites><orcidid>0000-0002-9966-9059</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35686604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Mi-Jin</creatorcontrib><creatorcontrib>Lee, Hyun Hee L</creatorcontrib><creatorcontrib>Lee, Hye-Bin</creatorcontrib><creatorcontrib>Do, Moon Ho</creatorcontrib><creatorcontrib>Park, Miri</creatorcontrib><creatorcontrib>Lee, Chang-Hyun</creatorcontrib><creatorcontrib>Park, Ho-Young</creatorcontrib><title>A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Radish (
Raphanus sativus
L.) is a rich source of nutrients and its greens have reported functionalities. This study aimed to investigate the effects of a water-soluble extract from radish greens (WERG) on adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obesity in model mice. We also quantified the phytochemical composition of WERG such as glucoraphenin and ferulic acid. These findings show that treatment with 100 μg mL
−1
WERG reduced lipid accumulation in 3T3-L1 adipocytes, whereas in mice, the administration of 100 mg kg
−1
WERG reduced weight gain and hepatic lipid accumulation and improved the levels of serum lipid biomarkers. Furthermore, WERG treatment improved intestinal permeability and suppressed the activities of harmful intestinal enzymes in feces, thus improving gut health. It also inhibited metabolic endotoxemia and inflammatory marker levels in serum. Moreover, WERG reduced the expression of lipid-metabolism-related proteins in the liver and white adipose tissue. Collectively, these results indicate that WERG may potentiate the anti-obesity effect by improving gut health and regulating lipid metabolism.
A water-soluble extract from radish greens (WERG) inhibits adipogenesis in 3T3-L1 adipocytes and ameliorates high fat diet-induced obesity in mice.</description><subject>Accumulation</subject><subject>Adipocytes</subject><subject>Adipogenesis</subject><subject>Adipose tissue</subject><subject>Animal models</subject><subject>Biomarkers</subject><subject>Body weight gain</subject><subject>Diet</subject><subject>Digestive system</subject><subject>Endotoxemia</subject><subject>Ferulic acid</subject><subject>Gastrointestinal tract</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Intestine</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Nutrients</subject><subject>Obesity</subject><subject>Permeability</subject><subject>Preadipocytes</subject><subject>Radishes</subject><subject>Raphanus sativus</subject><subject>Water chemistry</subject><subject>Weight reduction</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0U1LHDEYB_AgFRXrpfeWQC9SmJqXmWRyFF8LgheF3oa8PLMbmZlskwy6H8Dv3bjrWmguCckvD3nyR-gLJT8p4erM0T6QmjYM9tARIzWrREN-f9qtayUO0UlKT6QMrlSr2gN0yBvRCkHqI_R6jp91hohTGGYzAIaXHLXNOPQ4aufTEi8iwJSwHmHwIRac8NIvlrjXGTsPufKTmy04HAwkn9fYT3j0FrCeXFkvvfG5XHd-FRYwFZLexCrCZsuuS8HPaL_XQ4KT9_kYPV5fPVzcVnf3N78uzu8qy2WbKwOaU1n6U1xKY6yTjDhXM6aMbIVqXGHCNtwI05TODbVCCEn7vieMMAP8GJ1u665i-DNDyt3ok4Vh0BOEOXVMyKZ8S0tood__o09hjlN5XVGKklY2NSnqx1bZGFKK0Her6Ecd1x0l3Vs-3SW9vt_kc1Xwt_eSsxnBfdBdGgV83YKY7Mfpv4D5X8z9lYk</recordid><startdate>20220718</startdate><enddate>20220718</enddate><creator>Oh, Mi-Jin</creator><creator>Lee, Hyun Hee L</creator><creator>Lee, Hye-Bin</creator><creator>Do, Moon Ho</creator><creator>Park, Miri</creator><creator>Lee, Chang-Hyun</creator><creator>Park, Ho-Young</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9966-9059</orcidid></search><sort><creationdate>20220718</creationdate><title>A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes</title><author>Oh, Mi-Jin ; Lee, Hyun Hee L ; Lee, Hye-Bin ; Do, Moon Ho ; Park, Miri ; Lee, Chang-Hyun ; Park, Ho-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-bea3176509377bbcd720dd4229b78695dc376c53b6b5649b1c66671fff0202be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Accumulation</topic><topic>Adipocytes</topic><topic>Adipogenesis</topic><topic>Adipose tissue</topic><topic>Animal models</topic><topic>Biomarkers</topic><topic>Body weight gain</topic><topic>Diet</topic><topic>Digestive system</topic><topic>Endotoxemia</topic><topic>Ferulic acid</topic><topic>Gastrointestinal tract</topic><topic>High fat diet</topic><topic>Inflammation</topic><topic>Intestine</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Nutrients</topic><topic>Obesity</topic><topic>Permeability</topic><topic>Preadipocytes</topic><topic>Radishes</topic><topic>Raphanus sativus</topic><topic>Water chemistry</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Mi-Jin</creatorcontrib><creatorcontrib>Lee, Hyun Hee L</creatorcontrib><creatorcontrib>Lee, Hye-Bin</creatorcontrib><creatorcontrib>Do, Moon Ho</creatorcontrib><creatorcontrib>Park, Miri</creatorcontrib><creatorcontrib>Lee, Chang-Hyun</creatorcontrib><creatorcontrib>Park, Ho-Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Mi-Jin</au><au>Lee, Hyun Hee L</au><au>Lee, Hye-Bin</au><au>Do, Moon Ho</au><au>Park, Miri</au><au>Lee, Chang-Hyun</au><au>Park, Ho-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2022-07-18</date><risdate>2022</risdate><volume>13</volume><issue>14</issue><spage>7494</spage><epage>756</epage><pages>7494-756</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Radish (
Raphanus sativus
L.) is a rich source of nutrients and its greens have reported functionalities. This study aimed to investigate the effects of a water-soluble extract from radish greens (WERG) on adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obesity in model mice. We also quantified the phytochemical composition of WERG such as glucoraphenin and ferulic acid. These findings show that treatment with 100 μg mL
−1
WERG reduced lipid accumulation in 3T3-L1 adipocytes, whereas in mice, the administration of 100 mg kg
−1
WERG reduced weight gain and hepatic lipid accumulation and improved the levels of serum lipid biomarkers. Furthermore, WERG treatment improved intestinal permeability and suppressed the activities of harmful intestinal enzymes in feces, thus improving gut health. It also inhibited metabolic endotoxemia and inflammatory marker levels in serum. Moreover, WERG reduced the expression of lipid-metabolism-related proteins in the liver and white adipose tissue. Collectively, these results indicate that WERG may potentiate the anti-obesity effect by improving gut health and regulating lipid metabolism.
A water-soluble extract from radish greens (WERG) inhibits adipogenesis in 3T3-L1 adipocytes and ameliorates high fat diet-induced obesity in mice.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35686604</pmid><doi>10.1039/d1fo04152e</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9966-9059</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2022-07, Vol.13 (14), p.7494-756 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2675604801 |
| source | Royal Society Of Chemistry Journals |
| subjects | Accumulation Adipocytes Adipogenesis Adipose tissue Animal models Biomarkers Body weight gain Diet Digestive system Endotoxemia Ferulic acid Gastrointestinal tract High fat diet Inflammation Intestine Lipid metabolism Lipids Metabolism Nutrients Obesity Permeability Preadipocytes Radishes Raphanus sativus Water chemistry Weight reduction |
| title | A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T07%3A26%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20water%20soluble%20extract%20of%20radish%20greens%20ameliorates%20high%20fat%20diet-induced%20obesity%20in%20mice%20and%20inhibits%20adipogenesis%20in%20preadipocytes&rft.jtitle=Food%20&%20function&rft.au=Oh,%20Mi-Jin&rft.date=2022-07-18&rft.volume=13&rft.issue=14&rft.spage=7494&rft.epage=756&rft.pages=7494-756&rft.issn=2042-6496&rft.eissn=2042-650X&rft_id=info:doi/10.1039/d1fo04152e&rft_dat=%3Cproquest_pubme%3E2675604801%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2691087540&rft_id=info:pmid/35686604&rfr_iscdi=true |