Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy
Purpose The aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the ESR1 , PGR , CYP19A1, and COMT genes in pregnant and postpartum women. Methods The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2023-06, Vol.307 (6), p.1763-1770 |
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| creator | Schneider, Michael O. Pretscher, Jutta Goecke, Tamme W. Häberle, Lothar Engel, Anne Kornhuber, Johannes Eichler, Anna Ekici, Arif B. Beckmann, Matthias W. Fasching, Peter A. Schwenke, Eva |
| description | Purpose
The aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the
ESR1
,
PGR
,
CYP19A1,
and
COMT
genes in pregnant and postpartum women.
Methods
The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for assessment of maternal and fetal health. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of pregnancy, visit 2 was shortly after birth, and visit 3 was 6–8 months after birth. Germline DNA and depression measurements from 361 pregnant women were available for analysis. Six single nucleotide polymorphisms (SNPs) in the above-mentioned genes were genotyped. After reconstruction of haplotypes for
PGR
(rs1042838 and rs10895068) and
CYP19A1
(rs10046 and rs4646), a multifactorial linear mixed model was applied to the data to describe the association between haplotypes and depression values. The single SNPs for
ESR1
(rs488133) and
COMT
(rs4680) were analyzed separately using linear mixed models analogously.
Results
The mean antepartum EPDS measurement was 5.1, the mean postpartal measurement after 48–72 h was 3.5, and the mean value 6–8 months postpartum was 4.2. The SNPs in
PGR
were reconstructed into three haplotypes. The most common haplotype was GG, with 63.43% of patients carrying two copies and 33.52% carrying one copy. For haplotype GA, the group of carriers of two copies (0.28%) was combined with the carriers of one copy (9.70%). Haplotype reconstruction using
CYP19A1
SNPs resulted in three haplotypes. The most common haplotype was TC, with 25.48% of patients carrying two copies and 51.52% one copy. None of the haplotype blocks and neither of the two single SNPs showed any significant associations with EPDS values.
Conclusions
The candidate haplotypes analyzed in
PGR
and
CYP19A1
and single SNPs in
ESR1
and
COMT
did not show any association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women. |
| doi_str_mv | 10.1007/s00404-022-06644-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2675604367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2675604367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-53482ef4df30e8366a1f60c97cfa0f0a1546a969d1dc8e93d9f6c76d0e618fbc3</originalsourceid><addsrcrecordid>eNp9kU2PFCEQhonRuOvqH_BgSLx4aS0-mqaPZqOrySZe9EwYKGbZTEML3RPn38vMrB_x4AmKet63SL2EvGTwlgEM7yqABNkB5x0oJWWnH5FLJkUrB8Ye_3W_IM9qvQdgXGv1lFyIXmlQWl-S_Q0mXKKje1uiTUulMdHlDum2vVeaw6mo-IPWBUuOnt7lMuWEdMLFbvIu1ona5KnHuWCtcd_owzQvearUryWm7altQ5PThmyTTe7wnDwJdlfxxcN5Rb59_PD1-lN3--Xm8_X7286JoV-6XkjNMUgfBKAWSlkWFLhxcMFCAMt6qeyoRs-80zgKPwblBuUBFdNh48QVeXP2nUv-vmJdzBSrw93OJsxrNVwNvQIp1NDQ1_-g93ktqf3OcA0D5w3SjeJnypVca8Fg5hInWw6GgTmmYs6pmJaKOaVijqJXD9brZkL_W_IrhgaIM1Dn48aw_Jn9H9uflpeZSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2807223678</pqid></control><display><type>article</type><title>Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Schneider, Michael O. ; Pretscher, Jutta ; Goecke, Tamme W. ; Häberle, Lothar ; Engel, Anne ; Kornhuber, Johannes ; Eichler, Anna ; Ekici, Arif B. ; Beckmann, Matthias W. ; Fasching, Peter A. ; Schwenke, Eva</creator><creatorcontrib>Schneider, Michael O. ; Pretscher, Jutta ; Goecke, Tamme W. ; Häberle, Lothar ; Engel, Anne ; Kornhuber, Johannes ; Eichler, Anna ; Ekici, Arif B. ; Beckmann, Matthias W. ; Fasching, Peter A. ; Schwenke, Eva</creatorcontrib><description>Purpose
The aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the
ESR1
,
PGR
,
CYP19A1,
and
COMT
genes in pregnant and postpartum women.
Methods
The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for assessment of maternal and fetal health. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of pregnancy, visit 2 was shortly after birth, and visit 3 was 6–8 months after birth. Germline DNA and depression measurements from 361 pregnant women were available for analysis. Six single nucleotide polymorphisms (SNPs) in the above-mentioned genes were genotyped. After reconstruction of haplotypes for
PGR
(rs1042838 and rs10895068) and
CYP19A1
(rs10046 and rs4646), a multifactorial linear mixed model was applied to the data to describe the association between haplotypes and depression values. The single SNPs for
ESR1
(rs488133) and
COMT
(rs4680) were analyzed separately using linear mixed models analogously.
Results
The mean antepartum EPDS measurement was 5.1, the mean postpartal measurement after 48–72 h was 3.5, and the mean value 6–8 months postpartum was 4.2. The SNPs in
PGR
were reconstructed into three haplotypes. The most common haplotype was GG, with 63.43% of patients carrying two copies and 33.52% carrying one copy. For haplotype GA, the group of carriers of two copies (0.28%) was combined with the carriers of one copy (9.70%). Haplotype reconstruction using
CYP19A1
SNPs resulted in three haplotypes. The most common haplotype was TC, with 25.48% of patients carrying two copies and 51.52% one copy. None of the haplotype blocks and neither of the two single SNPs showed any significant associations with EPDS values.
Conclusions
The candidate haplotypes analyzed in
PGR
and
CYP19A1
and single SNPs in
ESR1
and
COMT
did not show any association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.</description><identifier>ISSN: 1432-0711</identifier><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-022-06644-8</identifier><identifier>PMID: 35680688</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Depression - diagnosis ; Depression - genetics ; Depression, Postpartum - diagnosis ; Depression, Postpartum - genetics ; Endocrinology ; Female ; Genotype ; Gynecology ; Haplotypes ; Human Genetics ; Humans ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Mental depression ; Obstetrics/Perinatology/Midwifery ; Parturition ; Polymorphism, Single Nucleotide ; Pregnancy ; Prospective Studies ; Womens health</subject><ispartof>Archives of gynecology and obstetrics, 2023-06, Vol.307 (6), p.1763-1770</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-53482ef4df30e8366a1f60c97cfa0f0a1546a969d1dc8e93d9f6c76d0e618fbc3</citedby><cites>FETCH-LOGICAL-c375t-53482ef4df30e8366a1f60c97cfa0f0a1546a969d1dc8e93d9f6c76d0e618fbc3</cites><orcidid>0000-0002-7583-307X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-022-06644-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-022-06644-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35680688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Michael O.</creatorcontrib><creatorcontrib>Pretscher, Jutta</creatorcontrib><creatorcontrib>Goecke, Tamme W.</creatorcontrib><creatorcontrib>Häberle, Lothar</creatorcontrib><creatorcontrib>Engel, Anne</creatorcontrib><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Eichler, Anna</creatorcontrib><creatorcontrib>Ekici, Arif B.</creatorcontrib><creatorcontrib>Beckmann, Matthias W.</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Schwenke, Eva</creatorcontrib><title>Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
The aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the
ESR1
,
PGR
,
CYP19A1,
and
COMT
genes in pregnant and postpartum women.
Methods
The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for assessment of maternal and fetal health. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of pregnancy, visit 2 was shortly after birth, and visit 3 was 6–8 months after birth. Germline DNA and depression measurements from 361 pregnant women were available for analysis. Six single nucleotide polymorphisms (SNPs) in the above-mentioned genes were genotyped. After reconstruction of haplotypes for
PGR
(rs1042838 and rs10895068) and
CYP19A1
(rs10046 and rs4646), a multifactorial linear mixed model was applied to the data to describe the association between haplotypes and depression values. The single SNPs for
ESR1
(rs488133) and
COMT
(rs4680) were analyzed separately using linear mixed models analogously.
Results
The mean antepartum EPDS measurement was 5.1, the mean postpartal measurement after 48–72 h was 3.5, and the mean value 6–8 months postpartum was 4.2. The SNPs in
PGR
were reconstructed into three haplotypes. The most common haplotype was GG, with 63.43% of patients carrying two copies and 33.52% carrying one copy. For haplotype GA, the group of carriers of two copies (0.28%) was combined with the carriers of one copy (9.70%). Haplotype reconstruction using
CYP19A1
SNPs resulted in three haplotypes. The most common haplotype was TC, with 25.48% of patients carrying two copies and 51.52% one copy. None of the haplotype blocks and neither of the two single SNPs showed any significant associations with EPDS values.
Conclusions
The candidate haplotypes analyzed in
PGR
and
CYP19A1
and single SNPs in
ESR1
and
COMT
did not show any association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.</description><subject>Depression - diagnosis</subject><subject>Depression - genetics</subject><subject>Depression, Postpartum - diagnosis</subject><subject>Depression, Postpartum - genetics</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Genotype</subject><subject>Gynecology</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Parturition</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Womens health</subject><issn>1432-0711</issn><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU2PFCEQhonRuOvqH_BgSLx4aS0-mqaPZqOrySZe9EwYKGbZTEML3RPn38vMrB_x4AmKet63SL2EvGTwlgEM7yqABNkB5x0oJWWnH5FLJkUrB8Ye_3W_IM9qvQdgXGv1lFyIXmlQWl-S_Q0mXKKje1uiTUulMdHlDum2vVeaw6mo-IPWBUuOnt7lMuWEdMLFbvIu1ona5KnHuWCtcd_owzQvearUryWm7altQ5PThmyTTe7wnDwJdlfxxcN5Rb59_PD1-lN3--Xm8_X7286JoV-6XkjNMUgfBKAWSlkWFLhxcMFCAMt6qeyoRs-80zgKPwblBuUBFdNh48QVeXP2nUv-vmJdzBSrw93OJsxrNVwNvQIp1NDQ1_-g93ktqf3OcA0D5w3SjeJnypVca8Fg5hInWw6GgTmmYs6pmJaKOaVijqJXD9brZkL_W_IrhgaIM1Dn48aw_Jn9H9uflpeZSg</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Schneider, Michael O.</creator><creator>Pretscher, Jutta</creator><creator>Goecke, Tamme W.</creator><creator>Häberle, Lothar</creator><creator>Engel, Anne</creator><creator>Kornhuber, Johannes</creator><creator>Eichler, Anna</creator><creator>Ekici, Arif B.</creator><creator>Beckmann, Matthias W.</creator><creator>Fasching, Peter A.</creator><creator>Schwenke, Eva</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7583-307X</orcidid></search><sort><creationdate>20230601</creationdate><title>Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy</title><author>Schneider, Michael O. ; Pretscher, Jutta ; Goecke, Tamme W. ; Häberle, Lothar ; Engel, Anne ; Kornhuber, Johannes ; Eichler, Anna ; Ekici, Arif B. ; Beckmann, Matthias W. ; Fasching, Peter A. ; Schwenke, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-53482ef4df30e8366a1f60c97cfa0f0a1546a969d1dc8e93d9f6c76d0e618fbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Depression - diagnosis</topic><topic>Depression - genetics</topic><topic>Depression, Postpartum - diagnosis</topic><topic>Depression, Postpartum - genetics</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Genotype</topic><topic>Gynecology</topic><topic>Haplotypes</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Parturition</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Michael O.</creatorcontrib><creatorcontrib>Pretscher, Jutta</creatorcontrib><creatorcontrib>Goecke, Tamme W.</creatorcontrib><creatorcontrib>Häberle, Lothar</creatorcontrib><creatorcontrib>Engel, Anne</creatorcontrib><creatorcontrib>Kornhuber, Johannes</creatorcontrib><creatorcontrib>Eichler, Anna</creatorcontrib><creatorcontrib>Ekici, Arif B.</creatorcontrib><creatorcontrib>Beckmann, Matthias W.</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Schwenke, Eva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Michael O.</au><au>Pretscher, Jutta</au><au>Goecke, Tamme W.</au><au>Häberle, Lothar</au><au>Engel, Anne</au><au>Kornhuber, Johannes</au><au>Eichler, Anna</au><au>Ekici, Arif B.</au><au>Beckmann, Matthias W.</au><au>Fasching, Peter A.</au><au>Schwenke, Eva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>307</volume><issue>6</issue><spage>1763</spage><epage>1770</epage><pages>1763-1770</pages><issn>1432-0711</issn><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
The aim of this study was to conduct an association analysis of depressive symptoms and polymorphisms in the
ESR1
,
PGR
,
CYP19A1,
and
COMT
genes in pregnant and postpartum women.
Methods
The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for assessment of maternal and fetal health. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of pregnancy, visit 2 was shortly after birth, and visit 3 was 6–8 months after birth. Germline DNA and depression measurements from 361 pregnant women were available for analysis. Six single nucleotide polymorphisms (SNPs) in the above-mentioned genes were genotyped. After reconstruction of haplotypes for
PGR
(rs1042838 and rs10895068) and
CYP19A1
(rs10046 and rs4646), a multifactorial linear mixed model was applied to the data to describe the association between haplotypes and depression values. The single SNPs for
ESR1
(rs488133) and
COMT
(rs4680) were analyzed separately using linear mixed models analogously.
Results
The mean antepartum EPDS measurement was 5.1, the mean postpartal measurement after 48–72 h was 3.5, and the mean value 6–8 months postpartum was 4.2. The SNPs in
PGR
were reconstructed into three haplotypes. The most common haplotype was GG, with 63.43% of patients carrying two copies and 33.52% carrying one copy. For haplotype GA, the group of carriers of two copies (0.28%) was combined with the carriers of one copy (9.70%). Haplotype reconstruction using
CYP19A1
SNPs resulted in three haplotypes. The most common haplotype was TC, with 25.48% of patients carrying two copies and 51.52% one copy. None of the haplotype blocks and neither of the two single SNPs showed any significant associations with EPDS values.
Conclusions
The candidate haplotypes analyzed in
PGR
and
CYP19A1
and single SNPs in
ESR1
and
COMT
did not show any association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35680688</pmid><doi>10.1007/s00404-022-06644-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7583-307X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-0711 |
| ispartof | Archives of gynecology and obstetrics, 2023-06, Vol.307 (6), p.1763-1770 |
| issn | 1432-0711 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2675604367 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Depression - diagnosis Depression - genetics Depression, Postpartum - diagnosis Depression, Postpartum - genetics Endocrinology Female Genotype Gynecology Haplotypes Human Genetics Humans Maternal-Fetal Medicine Medicine Medicine & Public Health Mental depression Obstetrics/Perinatology/Midwifery Parturition Polymorphism, Single Nucleotide Pregnancy Prospective Studies Womens health |
| title | Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy |
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