Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis in ApoE−/− mice

The main therapeutic strategies for coronary artery disease (CAD) are mainly based on the correction of abnormal cholesterol levels; however, residual risks remain. The newly proven gut microbial metabolite trimethylamine N-oxide (TMAO) linked with CAD has broadened our horizons. In this study, we d...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2022-09, Vol.170, p.60-74
Hauptverfasser:	Luo, Tiantian, Liu, Dan, Guo, Zhongzhou, Chen, Peier, Guo, Zhigang, Ou, Caiwen, Chen, Minsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Macrophage Proline/serine-rich coiled-coil protein 1 Sulfotransferase 2B1b Trimethylamine N-oxide
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Zusammenfassung:	The main therapeutic strategies for coronary artery disease (CAD) are mainly based on the correction of abnormal cholesterol levels; however, residual risks remain. The newly proven gut microbial metabolite trimethylamine N-oxide (TMAO) linked with CAD has broadened our horizons. In this study, we determined the role of proline/serine-rich coiled-coil protein 1 (PSRC1) in TMAO-driven atherosclerosis. We first analyzed the levels of TMAO and PSRC1 in patients with or without atherosclerosis with a target LDL-C
ISSN:	0022-2828 1095-8584
DOI:	10.1016/j.yjmcc.2022.05.013