A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects

The deuterium kinetic isotope effect has been used to affect the cytochrome P450 metabolism of the deuterated versions of substances. This study compares the pharmacokinetics of caffeine, a Generally Recognized As Safe food and beverage ingredient, versus d9-caffeine, a potential caffeine alternativ...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2022-08, Vol.133, p.105194-105194, Article 105194
Hauptverfasser:	Sherman, Mary M., Tarantino, Paul M., Morrison, Dennis N., Lin, Chun-Han, Parente, Ryan M., Sippy, Bradford C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caffeine d9-caffeine Deuteration Metabolites Pharmacokinetics (PK)
Online-Zugang:	Volltext
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