Extracellular vesicle-guided in situ reprogramming of synovial macrophages for the treatment of rheumatoid arthritis

Activation state of synovial macrophages is significantly correlated with disease activity and severity of rheumatoid arthritis (RA) and provides valuable clues for RA treatment. Classically activated M1 macrophages in inflamed synovial joints secrete high levels of pro-inflammatory cytokines and ch...

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Veröffentlicht in:	Biomaterials 2022-07, Vol.286, p.121578-121578, Article 121578
Hauptverfasser:	Kim, Hyosuk, Back, Ji Hyun, Han, Geonhee, Lee, Su Jin, Park, Yae Eun, Gu, Man Bock, Yang, Yoosoo, Lee, Ji Eun, Kim, Sun Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	biocompatible materials cartilage chemokines Extracellular vesicle gastrointestinal system immunotherapy Inflammation Macrophage macrophages methotrexate mice phenotype protein synthesis Reprogramming Rheumatoid arthritis toxicity
Online-Zugang:	Volltext
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