Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection

Two mycobacteriophages were administered intravenously to a male with treatment-refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung disease. The phages were engineered to enhance their capacity to lyse M. abscessus and were selected specifically as the most effecti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2022-05, Vol.185 (11), p.1860-1874.e12
Hauptverfasser:	Nick, Jerry A., Dedrick, Rebekah M., Gray, Alice L., Vladar, Eszter K., Smith, Bailey E., Freeman, Krista G., Malcolm, Kenneth C., Epperson, L. Elaine, Hasan, Nabeeh A., Hendrix, Jo, Callahan, Kimberly, Walton, Kendra, Vestal, Brian, Wheeler, Emily, Rysavy, Noel M., Poch, Katie, Caceres, Silvia, Lovell, Valerie K., Hisert, Katherine B., de Moura, Vinicius Calado, Chatterjee, Delphi, De, Prithwiraj, Weakly, Natalia, Martiniano, Stacey L., Lynch, David A., Daley, Charles L., Strong, Michael, Jia, Fan, Hatfull, Graham F., Davidson, Rebecca M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use bacteriophages Bacteriophages - genetics CFTR modulator therapy cystic fibrosis Cystic Fibrosis - drug therapy genetic stability Humans immunoglobulin intravenous injection lipoarabinomannan Lung lung transplant lungs Male males mycobacteriophage Mycobacterium abscessus Mycobacterium abscessus - physiology Mycobacterium avium Mycobacterium Infections, Nontuberculous - therapy nontuberculous mycobacterial lung disease NTM pathogens
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!