Mechanical activation drives tenogenic differentiation of human mesenchymal stem cells in aligned dense collagen hydrogels

Tendons are force transmitting mechanosensitive tissues predominantly comprised of highly aligned collagen type I fibres. In this study, the recently introduced gel aspiration-ejection method was used to rapidly fabricate aligned dense collagen (ADC) hydrogel scaffolds. ADCs provide a biomimetic env...

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Veröffentlicht in:	Biomaterials 2022-07, Vol.286, p.121606-121606, Article 121606
Hauptverfasser:	Park, Hyeree, Nazhat, Showan N., Rosenzweig, Derek H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alignment Anisotropy biocompatible materials biomimetics blood serum bone formation Cell Differentiation Cells, Cultured collagen Collagen - metabolism Collagen Type I - metabolism culture media Dense collagen Gel aspiration-ejection gene expression Humans Hydrogel hydrogels Hydrogels - metabolism Ligament Mechanobiology Mesenchymal Stem Cells mesenchymal stromal cells protein content Tendon tensile strength Tissue Engineering - methods
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