Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

Virus infection modulates both host immunity and host genomic stability. Poly(ADP-ribose) polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic integrity, and the successful application of PARP1 inhibitors for clinical anti-cancer therapy has lasted for decades. However...

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Veröffentlicht in:	Molecular cell 2022-06, Vol.82 (11), p.2032-2049.e7
Hauptverfasser:	Wang, Fei, Zhao, Mengmeng, Chang, Boran, Zhou, Yilong, Wu, Xiangyang, Ma, Mingtong, Liu, Siyu, Cao, Yajuan, Zheng, Mengge, Dang, Yifang, Xu, Junfang, Chen, Li, Liu, Tianhao, Tang, Fen, Ren, Yefei, Xu, Zhu, Mao, Zhiyong, Huang, Kai, Luo, Minhua, Li, Jinsong, Liu, Haipeng, Ge, Baoxue
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral immunity cancer therapy cyclic GMP-AMP synthase cytoplasm Cytoplasm - genetics Cytoplasm - metabolism DNA DNA Damage DNA damage response DNA viruses DNA-dependent protein kinase genetic instability Genomic Instability genomics Humans immunity inducible nitric oxide synthase Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism PARylation Poly (ADP-Ribose) Polymerase-1 - metabolism poly(ADP-ribose) polymerase 1 protein kinases reactive nitrogen species type I interferon viruses
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