Studying Lipophilicity Trends of Phosphorus Compounds by 31P‑NMR Spectroscopy: A Powerful Tool for the Design of P‑Containing Drugs
Systematically studying the lipophilicity of phosphorus compounds is of great importance for many chemical and biological fields and particularly for medicinal chemistry. Here, we report on the study of trends in the lipophilicity of a wide set of phosphorus compounds relevant to drug design includi...
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| Veröffentlicht in: | Journal of medicinal chemistry 2022-06, Vol.65 (12), p.8511-8524 |
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| creator | Columbus, Ishay Ghindes-Azaria, Lee Chen, Ravit Yehezkel, Lea Redy-Keisar, Orit Fridkin, Gil Amir, Dafna Marciano, Daniele Drug, Eyal Gershonov, Eytan Klausner, Ziv Saphier, Sigal Elias, Shlomi Pevzner, Alexander Eichen, Yoav Parvari, Galit Smolkin, Boris Zafrani, Yossi |
| description | Systematically studying the lipophilicity of phosphorus compounds is of great importance for many chemical and biological fields and particularly for medicinal chemistry. Here, we report on the study of trends in the lipophilicity of a wide set of phosphorus compounds relevant to drug design including phosphates, thiophosphates, phosphonates, thiophosphonates, bis-phosphonates, and phosphine chalcogenides. This was enabled by the development of a straightforward log P determination method for phosphorus compounds based on 31P-NMR spectroscopy. The log P values measured ranged between −3.2 and 3.6, and the trends observed were interpreted using a DFT study of the dipole moments and by H-bond basicity (pK HB) measurements of selected compounds. Clear signal separation in 31P-NMR spectroscopy grants the method high tolerability to impurities. Moreover, the wide range of chemical shifts for the phosphorus nucleus (250 to −250 ppm) enables a direct simultaneous log P determination of phosphorus compound mixtures in a single shake-flask experiment and 31P-NMR analysis. |
| doi_str_mv | 10.1021/acs.jmedchem.2c00658 |
| format | Article |
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Here, we report on the study of trends in the lipophilicity of a wide set of phosphorus compounds relevant to drug design including phosphates, thiophosphates, phosphonates, thiophosphonates, bis-phosphonates, and phosphine chalcogenides. This was enabled by the development of a straightforward log P determination method for phosphorus compounds based on 31P-NMR spectroscopy. The log P values measured ranged between −3.2 and 3.6, and the trends observed were interpreted using a DFT study of the dipole moments and by H-bond basicity (pK HB) measurements of selected compounds. Clear signal separation in 31P-NMR spectroscopy grants the method high tolerability to impurities. 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Med. Chem</addtitle><date>2022-06-23</date><risdate>2022</risdate><volume>65</volume><issue>12</issue><spage>8511</spage><epage>8524</epage><pages>8511-8524</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><abstract>Systematically studying the lipophilicity of phosphorus compounds is of great importance for many chemical and biological fields and particularly for medicinal chemistry. Here, we report on the study of trends in the lipophilicity of a wide set of phosphorus compounds relevant to drug design including phosphates, thiophosphates, phosphonates, thiophosphonates, bis-phosphonates, and phosphine chalcogenides. This was enabled by the development of a straightforward log P determination method for phosphorus compounds based on 31P-NMR spectroscopy. The log P values measured ranged between −3.2 and 3.6, and the trends observed were interpreted using a DFT study of the dipole moments and by H-bond basicity (pK HB) measurements of selected compounds. Clear signal separation in 31P-NMR spectroscopy grants the method high tolerability to impurities. 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| title | Studying Lipophilicity Trends of Phosphorus Compounds by 31P‑NMR Spectroscopy: A Powerful Tool for the Design of P‑Containing Drugs |
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