DNA-Programmed Orientation-Ordered Multivalent Microfluidic Interface for Liquid Biopsy

Aptamer-functionalized microfluidic interfaces hold great potential for liquid biopsies owing to their programmable nature. However, most previous studies have focused on development of multivalent aptamers to improve binding affinity, while ignoring aptamer orientation on microfluidic interfaces, r...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-06, Vol.94 (24), p.8766-8773
Hauptverfasser:	Peng, Jiao, Liu, Yilong, Su, Rui, Zeng, Liuqing, Huo, Zixuan, Peng, Ruixiao, Yu, Xiyuan, Zhang, Huimin, Yang, Chaoyong, Yang, Liu, Zhu, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analytical chemistry Aptamers Binding Biopsy Chemistry Deoxyribonucleic acid DNA Interfaces Leukemia Lymphocytes T Microfluidics Nuclease Orientation Patients Peripheral blood T cell receptors Tumor cells Valency
Online-Zugang:	Volltext
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