Murine cytomegalovirus promotes renal allograft inflammation via Th1/17 cells and IL‐17A

Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. Allograft damage in animal models is accelerated by CMV‐induced T helper 17 (Th17) cell infiltrates. However, the mechanisms whereby CMV promotes Th17 cell‐mediated pathological organ inflammation are uncharacterized....

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Veröffentlicht in:	American journal of transplantation 2022-10, Vol.22 (10), p.2306-2322
Hauptverfasser:	Dhital, Ravi, Anand, Shashi, Graber, Brianna, Zeng, Qiang, Velazquez, Victoria M., Boddeda, Srinivasa R., Fitch, James R., Minz, Ranjana W., Minz, Mukut, Sharma, Ashish, Cianciolo, Rachel, Shimamura, Masako
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts - metabolism Animal models Animals Antiviral Agents Antiviral drugs basic (laboratory) research/science CCL20 protein CCR6 protein chemokines/chemokine receptors clinical research/practice CXCL10 protein CXCR3 protein Cytokines Cytokines - metabolism Cytomegalovirus Cytomegalovirus Infections Graft rejection Helper cells Humans infection and infectious agents—viral: cytomegalovirus (CMV) Inflammation Inflammation - pathology Interferon Interleukin-17 - metabolism Ischemia Kidney transplantation Kidney Transplantation - adverse effects kidney transplantation/nephrology Kidney transplants Lymphocytes T Mice Muromegalovirus Nephritis Phenotypes rejection: acute, cytokines/cytokine receptors Renal failure Renal Insufficiency - complications Reperfusion Th1 Cells Th17 Cells Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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