Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion

To investigate the effect of rapamycin on mitochondrial dynamic balance in diabetic rats subjected to cerebral ischemia-reperfusion injury. Male Sprague Dawley (SD) rats ( n = 78) were treated with high fat diet combined with streptozotocin injection to construct diabetic model in rats. Transient m...

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Veröffentlicht in:	Metabolic brain disease 2023-02, Vol.38 (2), p.409-418
Hauptverfasser:	Hei, Changchun, Zhou, Yujia, Zhang, Chenyang, Gao, Furong, Cao, Meiling, Yuan, Shilin, Qin, Yixin, Li, P. Andy, Yang, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - metabolism Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Brain damage Brain Injuries - complications Brain injury Brain Ischemia - metabolism Cell death Cerebral blood flow Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Dynamin High fat diet Hyperglycemia Immunohistochemistry Infarction, Middle Cerebral Artery - drug therapy Ischemia Male Metabolic Diseases Mitochondria Mitochondrial Dynamics Neurology Neurosciences Occlusion Oncology Original Article Proteins Rapamycin Rats Rats, Sprague-Dawley Reperfusion Reperfusion Injury - complications Reperfusion Injury - drug therapy Sirolimus - pharmacology Sirolimus - therapeutic use Sirtuin 3 - metabolism Streptozocin TOR protein TOR Serine-Threonine Kinases - metabolism Western blotting
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