Cellular and molecular basis for the action of retinoic acid in spermatogenesis
Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the mammalian male. This is possible because of an active stem cell pool and an ordered entry into the germ cell developmental sequence. The orde...
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| Veröffentlicht in: | Journal of molecular endocrinology 2022-11, Vol.69 (4), p.T51-T57 |
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| container_title | Journal of molecular endocrinology |
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| creator | Griswold, Michael D |
| description | Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the mammalian male. This is possible because of an active stem cell pool and an ordered entry into the germ cell developmental sequence. The ordered entry is a result of the synthesis and action of retinoic acid allowing for the onset of spermatogonial differentiation and an irreversible commitment to spermatogenesis. The periodic appearance and actions of retinoic acid along the seminiferous tubules is a result of the interactions between germ cells and Sertoli cells that result in the generation and maintenance of the cycle of the seminiferous epithelium and is the subject of this review. |
| doi_str_mv | 10.1530/JME-22-0067 |
| format | Article |
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| ispartof | Journal of molecular endocrinology, 2022-11, Vol.69 (4), p.T51-T57 |
| issn | 0952-5041 1479-6813 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Society for Endocrinology Journals |
| subjects | Animals Epithelium Gametes Germ cells Male Mammals - metabolism Retinoic acid Seminiferous Epithelium - metabolism Sertoli cells Sertoli Cells - metabolism Spermatogenesis Spermatogonia - metabolism Stem cells Testis - metabolism Thematic Review Tretinoin - metabolism Tretinoin - pharmacology Tubules |
| title | Cellular and molecular basis for the action of retinoic acid in spermatogenesis |
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